DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rk and cxcr4

DIOPT Version :9

Sequence 1:	NP_476702.1	Gene:	rk / 34819	FlyBaseID:	FBgn0003255	Length:	1360	Species:	Drosophila melanogaster
Sequence 2:	NP_001090831.1	Gene:	cxcr4 / 100038176	XenbaseID:	XB-GENE-489917	Length:	358	Species:	Xenopus tropicalis

Alignment Length:	353	Identity:	96/353 - (27%)
Similarity:	137/353 - (38%)	Gaps:	81/353 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   716 GFGTG----LFSGMSTE----DFQPGSVQCLPMPGP-----FLPCADLFDWWTLRCGVWVVFLLS 767
            ||..|    :|...|||    ||:..|..|......     |||....|           :|||.
Frog     3 GFSGGIDINIFDSNSTENGSGDFEDFSEPCFMHDNSDFNRIFLPTIYSF-----------IFLLG 56

  Fly   768 LLGNGTVVFVL---LCSRSKMDVPRFLVCNLAAADFFMGIYLGILAIVDAATLGEFRMFAIPWQM 829
            ::|||.||.|:   ..||:..|..|.   :|:.||......|...: ||||....|:.|
Frog    57 IIGNGLVVVVMGYQKKSRTMTDKYRL---HLSVADLLFVFTLPFWS-VDAAIGWYFKEF------ 111

  Fly   830 SVLCQLSGFLAVLSSELSVYTLAVITLERNYAITHAIHLNKRLSLKQ-AGYIMSVG-WVFALIMA 892
              ||:....:..::...||..||.|:|:|..||.||  .|.:.|.|. |..::..| |:.||::.
Frog   112 --LCKAVHVIYTVNLYSSVLILAFISLDRYLAIVHA--TNSQGSRKMLADKVVYAGVWLPALLLT 172

  Fly   893 LMPLV--GVSDYRKFAVC---LPFETTTGPASLTYVISLMFINGCAFLTLMG-----CYLKMYWA 947
            :..||  .|||.....||   .|.:...     |:.:...|::....|.|.|     ||..:...
Frog   173 VPDLVFARVSDENGQFVCDRIYPIDNRE-----TWTVGFRFLHITVGLILPGLIILICYCVIISK 232

  Fly   948 IRGSQAWNTNDSRIAKRMALLVFTDFLCWSPIAFFSITAIFGL---------------QLISLEQ 997
            :..|:.....  :..|...:|:...|.||.|......|..|.|               :.||:.:
Frog   233 LSHSKGHQKR--KALKTTVILILAFFACWLPYYVCLTTDTFMLLGLLKADCIWENTLHKAISITE 295

  Fly   998 AKIFTVFVLPLNSCCNPFLYAIMTKQFK 1025
            |..|      .:.|.||.|||.:..:||
Frog   296 ALAF------FHCCLNPILYAFLGAKFK 317

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rk	NP_476702.1	leucine-rich repeat	158..179	CDD:275380
		LRR_RI	180..>383	CDD:238064
		leucine-rich repeat	183..204	CDD:275380
		LRR_8	203..263	CDD:290566
		leucine-rich repeat	205..228	CDD:275380
		leucine-rich repeat	229..252	CDD:275380
		LRR_8	252..311	CDD:290566
		leucine-rich repeat	253..276	CDD:275380
		leucine-rich repeat	277..300	CDD:275380
		LRR_8	299..359	CDD:290566
		leucine-rich repeat	301..324	CDD:275380
		leucine-rich repeat	325..348	CDD:275380
		LRR_RI	327..567	CDD:238064
		leucine-rich repeat	349..371	CDD:275380
		LRR_8	370..425	CDD:290566
		leucine-rich repeat	372..393	CDD:275380
		leucine-rich repeat	394..415	CDD:275380
		leucine-rich repeat	418..486	CDD:275380
		leucine-rich repeat	441..464	CDD:275378
		LRR_8	487..545	CDD:290566
		leucine-rich repeat	487..510	CDD:275380
		leucine-rich repeat	511..534	CDD:275380
		LRR_8	533..589	CDD:290566
		leucine-rich repeat	535..558	CDD:275380
		leucine-rich repeat	559..580	CDD:275380
		7tm_4	764..>892	CDD:304433	44/132 (33%)
		7tm_1	770..1017	CDD:278431	73/276 (26%)
cxcr4	NP_001090831.1	Important for chemokine binding and signaling. /evidence=ECO:0000250	1..25		7/21 (33%)
		CXCR4_N	10..42	CDD:371902	8/31 (26%)
		7tmA_CXCR4	43..320	CDD:341334	85/313 (27%)
		TM helix 1	43..70	CDD:341334	13/37 (35%)
		TM helix 2	77..102	CDD:341334	7/28 (25%)
		Chemokine binding. /evidence=ECO:0000250	98..101		0/3 (0%)
		TM helix 3	113..143	CDD:341334	9/29 (31%)
		Chemokine binding. /evidence=ECO:0000250	117..121		0/3 (0%)
		Involved in dimerization, when bound to chemokine. /evidence=ECO:0000250	139..151		5/13 (38%)
		TM helix 4	155..177	CDD:341334	5/21 (24%)
		Chemokine binding, important for signaling. /evidence=ECO:0000250	190..194		1/3 (33%)
		TM helix 5	203..232	CDD:341334	6/28 (21%)
		TM helix 6	239..269	CDD:341334	6/31 (19%)
		TM helix 7	288..313	CDD:341334	10/30 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	338..358
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910