DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rk and lrrtm4l1

DIOPT Version :9

Sequence 1:	NP_476702.1	Gene:	rk / 34819	FlyBaseID:	FBgn0003255	Length:	1360	Species:	Drosophila melanogaster
Sequence 2:	NP_001373591.1	Gene:	lrrtm4l1 / 100000724	ZFINID:	ZDB-GENE-080327-15	Length:	571	Species:	Danio rerio

Alignment Length:	678	Identity:	143/678 - (21%)
Similarity:	232/678 - (34%)	Gaps:	198/678 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   135 AGKRTLHSICERWLQKHCHCTGSLEVLRLSCRGIGILAVPVNLPNEVVVLDLGNNNLTKLEANSF 199
            |....|.|..||.....|||.|.:    :.|.......||.|:......|.|..|:|..:....|
Zfish    18 ASSLLLFSSGERMCPYSCHCEGKI----VHCESSAFQDVPENISVSCQGLSLRYNDLHTMLPYQF 78

  Fly   200 FMAPNLEELTLSDNSIINMDPNAFYGLAKLKRLSLQNCGLKSLPPQSFQGLAQLTSLQLNGNALV 264
            .....|..|.|..|.|:.:|..||.|:.:||.|.|.:..:..|...:|.|:..|.||.|:.|.|.
Zfish    79 AHLNQLLWLYLDHNQIMFVDSRAFQGVRRLKELILSSNRISQLHNVTFHGVPNLRSLDLSYNKLQ 143

  Fly   265 SLDGDCLGHLQKLRTLRLEGNLFYRIPTNALAGLRTLEALNLGSNLLTIINDEDFPRMPNLIVLL 329
            .|.......|:||:.|.|..|....||..|....|:||.|:||.|.|.::....|..:..|:.|.
Zfish   144 ELQPGQFYGLRKLQNLHLRSNGLTAIPVRAFLECRSLEFLDLGYNRLRVLTRTAFLGLSRLMELH 208

  Fly   330 LKRNQIMKISAGALKNLTALKVLELDDNLISSLPEGLSKLSQLQELSITSNRLRWINDTELPRSM 394
            |:.||..:|:......|..|:.|.|..|.|.::.:||.              ..|.       ::
Zfish   209 LEHNQFSRINFFLFPRLANLRALYLQWNRIRAVNQGLP--------------WSWY-------TL 252

  Fly   395 QMLDMRANPLSTISPGAFRGMSKLRKLILSDVRTLRSFPELEACHALEILKLDRAGIQEVPANLC 459
            |.||:..|.:..:.|..|:.:
Zfish   253 QRLDISGNEIQVLDPVVFQCL-------------------------------------------- 273

  Fly   460 RQTPRLKSLELKTNSLKRIPN--LSSCRDLRLLDLSSNQIEKIQG--------KPFNGLKQLNDL 514
               |.|:.|.|::|.|..:..  :::...|..:.|:.|..:...|        |.|.|.|..|.:
Zfish   274 ---PNLQVLNLESNKLANVSQEVVAAWISLTTISLAGNMWDCGPGICPLVVWLKNFRGTKDTNII 335

  Fly   515 LLSYNRIKALPQDAFQGIPKLQLLDLEGNEISYIHKEAFSGFTALEDLNLGNNIFPELPESGLRA 579
            ..|               ||    .|:|.::.    ||...:...:|.           |...::
Zfish   336 CSS---------------PK----HLQGEKVI----EASKNYIDCDDY-----------EITAQS 366

  Fly   580 LLHLKTFN----------NPKLREFPPPDTFPRIQTLILSYAYHCCAFLPLVAMSSQKKTSQVQE 634
            .|:|:||:          .|.:....||...|       |.|.. ..|.|.......:.|
Zfish   367 PLYLQTFDPNYDLALEPTEPTMAPTTPPPPLP-------SPASE-APFPPPQPRPPHRPT----- 418

  Fly   635 AVLFPSDAEFD--------MTLWNNSMMNIWPQMHNLS--------------------------K 665
               |||....|        .:.:::|::...|:..|:|                          |
Zfish   419 ---FPSRTNTDPRDSHQRTPSSFDSSLVTPVPEQDNVSFHKVVMGGVALFFSVSLVLSVIYVSCK 480

  Fly   666 QLGASMHDPWETAINFNEEQLQTQTGGQIATSYMEEYFEEHDVSGPATG------YGFGTGLFSG 724
            :...:.....::::. .:.:.::|...|..:|.::||:..::   ||..      .|.|||..:.
Zfish   481 RYPGATRLLQQSSVG-RKRRKKSQEPEQNLSSQLQEYYMSYN---PAATPEALEVLGNGTGTCTC 541

  Fly   725 MSTEDFQPGSVQC-------LPMPGPFL 745
            ..:     ||.:|       .|:||.::
Zfish   542 TIS-----GSRECENEYSCPRPLPGAWI 564

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rk	NP_476702.1	leucine-rich repeat	158..179	CDD:275380	4/20 (20%)
		LRR_RI	180..>383	CDD:238064	60/202 (30%)
		leucine-rich repeat	183..204	CDD:275380	5/20 (25%)
		LRR_8	203..263	CDD:290566	21/59 (36%)
		leucine-rich repeat	205..228	CDD:275380	9/22 (41%)
		leucine-rich repeat	229..252	CDD:275380	7/22 (32%)
		LRR_8	252..311	CDD:290566	23/58 (40%)
		leucine-rich repeat	253..276	CDD:275380	8/22 (36%)
		leucine-rich repeat	277..300	CDD:275380	7/22 (32%)
		LRR_8	299..359	CDD:290566	20/59 (34%)
		leucine-rich repeat	301..324	CDD:275380	8/22 (36%)
		leucine-rich repeat	325..348	CDD:275380	7/22 (32%)
		LRR_RI	327..567	CDD:238064	43/249 (17%)
		leucine-rich repeat	349..371	CDD:275380	7/21 (33%)
		LRR_8	370..425	CDD:290566	7/54 (13%)
		leucine-rich repeat	372..393	CDD:275380	1/20 (5%)
		leucine-rich repeat	394..415	CDD:275380	6/20 (30%)
		leucine-rich repeat	418..486	CDD:275380	6/69 (9%)
		leucine-rich repeat	441..464	CDD:275378	0/22 (0%)
		LRR_8	487..545	CDD:290566	14/65 (22%)
		leucine-rich repeat	487..510	CDD:275380	7/30 (23%)
		leucine-rich repeat	511..534	CDD:275380	2/22 (9%)
		LRR_8	533..589	CDD:290566	12/65 (18%)
		leucine-rich repeat	535..558	CDD:275380	4/22 (18%)
		leucine-rich repeat	559..580	CDD:275380	2/20 (10%)
		7tm_4	764..>892	CDD:304433
		7tm_1	770..1017	CDD:278431
lrrtm4l1	NP_001373591.1	leucine-rich repeat	60..83	CDD:275380	5/22 (23%)
		LRR_8	63..118	CDD:404697	18/54 (33%)
		leucine-rich repeat	84..107	CDD:275380	9/22 (41%)
		LRR_8	106..166	CDD:404697	20/59 (34%)
		leucine-rich repeat	108..131	CDD:275380	7/22 (32%)
		leucine-rich repeat	132..155	CDD:275380	8/22 (36%)
		PPP1R42	153..308	CDD:411060	47/222 (21%)
		leucine-rich repeat	156..179	CDD:275380	7/22 (32%)
		leucine-rich repeat	180..203	CDD:275380	8/22 (36%)
		leucine-rich repeat	204..227	CDD:275380	7/22 (32%)
		leucine-rich repeat	228..251	CDD:275380	8/43 (19%)
		leucine-rich repeat	252..275	CDD:275380	6/69 (9%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910