Protein Alignment NimC2 and MEGF11

DIOPT Version :9

• Sequence 1: NP_001285922.1
• Gene: NimC2 / 34818
• FlyBaseID: FBgn0028939
• Length: 701
• Species: Drosophila melanogaster
• Sequence 2: NP_001371957.1
• Gene: MEGF11 / 84465
• HGNCID: 29635
• Length: 1140
• Species: Homo sapiens
• Alignment Length: 878
• Identity: 224/878 - (25%)
• Similarity: 293/878 - (33%)
• Gaps: 337/878 - (38%)

  Fly    65 CCDGYIRDENNECVPLCNDCGASGKCLLPNVCLCGKGY-----VSRKDHGHCEPECSESCVNGKC 124
            ||.||. :..:.|:|||.:....|:|:.|:.|.|..|:     .|..|..|..|.||..|
Human    88 CCPGYY-ESGDFCIPLCTEECVHGRCVSPDTCHCEPGWGGPDCSSGCDSDHWGPHCSNRC----- 146

  Fly   125 VAPDECECLAGHRFVNGSQTACEPICVEDCANGRCLETGKCLCNNGYQ--RDEKL-------KKC 180
                :|:        ||:  .|.||            ||.|:|..|::  |.|:|       |.|
Human   147 ----QCQ--------NGA--LCNPI------------TGACVCAAGFRGWRCEELCAPGTHGKGC 185

  Fly   181 VPICQDACYHGDCVAP--NECRCHPGHEQRLGVPWICDPICSSGCANGYCQGAEVCACKMGYAHK 243
            ...||  |.||....|  .||.|.||:   .||  .|:.:|..|....:|:..  |.|:.|....
Human   186 QLPCQ--CRHGASCDPRAGECLCAPGY---TGV--YCEELCPPGSHGAHCELR--CPCQNGGTCH 241

  Fly   244 DNTLASGCEP-----VCNPPCTNGT----CIS-------------PGHCACSEGHVFAEGSRHEC 286
            ..|....|.|     ||..||..||    |..             .|.|.|:.|::   |.|  |
Human   242 HITGECACPPGWTGAVCAQPCPPGTFGQNCSQDCPCHHGGQCDHVTGQCHCTAGYM---GDR--C 301

  Fly   287 VPSCRSG-----------CENGYCSSP--GRCECHEGF------EKTSPH--------------- 317
            ...|..|           |.||...||  |.|||..|:      |:..|.
Human   302 QEECPFGSFGFQCSQHCDCHNGGQCSPTTGACECEPGYKGPRCQERLCPEGLHGPGCTLPCPCDA 366

  Fly   318 ----RCSP-----TCRPG-----CGQN-------SRCAAPDTCACDVGYVFVNGSTT-------- 353
                .|.|     ||:||     |.::       ..|..|.||........:.|..|
Human   367 DNTISCHPVTGACTCQPGWSGHHCNESCPVGYYGDGCQLPCTCQNGADCHSITGGCTCAPGFMGE 431

  Fly   354 -------------ECEPFCPRNCRNGICSSP--GVCTCLEGFQALLSFYCIPVC----------- 392
                         .|...|  :|.||...||  |.|||.||:|.|   .|...|
Human   432 VCAVSCAAGTYGPNCSSIC--SCNNGGTCSPVDGSCTCKEGWQGL---DCTLPCPSGTWGLNCNE 491

  Fly   393 SKTCIHGSCVAP--NECRCFTGYR--------PNPSLGANV-----------CEPI--------- 427
            |.||.:|:..:|  ..|.|..|:.        |:.:.|.|.           |:|:
Human   492 SCTCANGAACSPIDGSCSCTPGWLGDTCELPCPDGTFGLNCSEHCDCSHADGCDPVTGHCCCLAG 556

  Fly   428 ---------CSQG-----------CVHGFCIAPE--ICQCDLGFIKRWATGTCEP----H----- 461
                     |..|           |.:|...:||  .|:|..||........|.|    |
Human   557 WTGIRCDSTCPPGRWGPNCSVSCSCENGGSCSPEDGSCECAPGFRGPLCQRICPPGFYGHGCAQP 621

  Fly   462 CPQKCVNS----HCLGSGVCRCYEGYKLRPGSTSICDPECQPG------------CRNGTCVEP- 509
            || .||:|    |.: ||:|.|..|:     |.::|:..|..|            ..|||| .|
Human   622 CP-LCVHSSRPCHHI-SGICECLPGF-----SGALCNQVCAGGYFGQDCAQLCSCANNGTC-SPI 678

  Fly   510 -NSCACFAGYEDTKVPYECVPSCRP-----------RCENG-RCSS-PGHCECDPGHVVTNSSE- 559
             .||.||.|:    :..:|..:|.|           .|.|| .||: .|.|.|.||......::
Human   679 DGSCQCFPGW----IGKDCSQACPPGFWGPACFHACSCHNGASCSAEDGACHCTPGWTGLFCTQR 739

  Fly   560 ------PNSCRPQCQEQCIN-AEC-VAPEKCACLPRYRFLPDSSTECEPICSK-----GCLSGQE 611
                  ...|...|  ||.| |.| ....||.|...:     :...||..|:.     ||....|
Human   740 CPAAFFGKDCGRVC--QCQNGASCDHISGKCTCRTGF-----TGQHCEQRCAPGTFGYGCQQLCE 797

  Fly   612 CVAPDTC----------AGFESL-----------------ISPTTGKHLAFHWSMFVLAILLCLA 649
            |:...||          .||:.:                 |||..|...  |....|..|:|.|.
Human   798 CMNNSTCDHVTGTCYCSPGFKGIRCDQAALMMEELNPYTKISPALGAER--HSVGAVTGIMLLLF 860

  Fly   650 LVMIPLLVLREMQRRRRNGDKQSSR-LIENPSY 681
            |::: ||.|....|||:   |:..| |....||
Human   861 LIVV-LLGLFAWHRRRQ---KEKGRDLAPRVSY 889

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NimC2	NP_001285922.1	None
MEGF11	NP_001371957.1	EMI	26..93	CDD:400092	3/4 (75%)
		EGF_CA	275..320	CDD:419698	9/49 (18%)
		EGF_CA	362..409	CDD:419698	9/46 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1218
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810