DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment NimC2 and Tnxb

DIOPT Version :9

Sequence 1:	NP_001285922.1	Gene:	NimC2 / 34818	FlyBaseID:	FBgn0028939	Length:	701	Species:	Drosophila melanogaster
Sequence 2:	XP_006525248.1	Gene:	Tnxb / 81877	MGIID:	1932137	Length:	4361	Species:	Mus musculus

Alignment Length:	729	Identity:	195/729 - (26%)
Similarity:	260/729 - (35%)	Gaps:	219/729 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 GC---------VKQAQVVKMRGTLVT-----MRKHQNSANCTTNCGPLVGRTRTETYLGFTDV-- 64
            ||         ..:.|.:::|..::.     :::|     ||..|.|...:..|    |.|||
Mouse    75 GCPPGSEPPVPASEVQALRVRLEILEELVKGLKEH-----CTGGCCPTAAQAGT----GQTDVRS 130

  Fly    65 CCDGYIRDENNECV---------PLCN-------------------DCGASGKCLLPNVCLCGKG 101
            .|..:...:.:.|.         |.|:                   ||...|:|:... |:|..|
Mouse   131 LCSLHGVFDLSRCACSCEPGWGGPTCSDPTDTKTPTSSPPSKSCPEDCNDQGRCVRGR-CVCFPG 194

  Fly   102 YVSRKDHGHCE-PECSESCV-NGKCVAPDECECLAGHRFVNGSQTACEPICVEDCANGRCLETGK 164
            |....    |. |.|...|. .|:|| ...|.|.||....:.||.:|...|.:   .||| |.|:
Mouse   195 YSGPS----CSWPSCPGDCQGRGRCV-KGVCVCRAGFSGPDCSQRSCPRNCNQ---RGRC-EEGR 250

  Fly   165 CLCNNGYQ-RDEKLKKCVPIC--QDACYHGDCVAPNECRCHPGHE-QRLGVPWICDPICSSGCA- 224
            |:|:.||. .|..::.|...|  :..|.:|.||      |:||:. :..||     ..|..||:
Mouse   251 CVCDPGYSGEDCGVRSCPRGCSQRGRCENGLCV------CNPGYSGEDCGV-----RNCPRGCSQ 304

  Fly   225 NGYCQGAEVCACKMGYAHKDNTLASGCEPVCNPPCTNGTCISPGHCACSEGHVFAEGSRHECVPS 289
            .|.|:... |.|..||:.:|.::.:     |...|.:|.....|.|.|..|:...:.|...|...
Mouse   305 RGRCEDGR-CVCDPGYSGEDCSMRT-----CPWDCGDGGRCVDGRCVCWPGYSGEDCSTRTCPRD 363

  Fly   290 CRSGCENGYCSSPGRCECHEGFEKTSPHRCSPTCRPG-CGQNSRCAAPDTCACDVGYVFVNGSTT 353
            ||.   .|.|.. |.|.|..|:   |...|.....|| |.|...| ....|.|..||...:.||.
Mouse   364 CRG---RGRCED-GECICDAGY---SGDDCGVRSCPGDCNQRGHC-EDGRCVCWPGYTGADCSTR 420

  Fly   354 ECEPFCPRNCR-NGICSSPGVCTCLEGFQALLSFYCIPVCSKTCIHGSCVAPNECR--------- 408
            .    |||:|| .|.|.. |||.|..|:.           .:.|...||  |.:||
Mouse   421 A----CPRDCRGRGRCED-GVCVCHAGYS-----------GEDCGVRSC--PGDCRGRGNCESGR 467

  Fly   409 --CFTGYRPNPSLGANVCEPIC-SQG-CVHGFCIAPEICQCDLGFI-----KRWATGTCEPH--- 461
              |:.|| .....|...|...| .:| ||.|.|:      |:.||.     .|...|.|..|
Mouse   468 CVCWPGY-TGRDCGTRACPGDCRGRGRCVDGRCV------CNPGFTGEDCGSRRCPGDCRGHGHC 525

  Fly   462 --------------------CPQKC-VNSHCLGSGVCRCYEGYKLRPGSTSICDPECQPGCRNGT 505
                                ||..| ....|| :|:|.|.|||.........|..:|.   ::|.
Mouse   526 ENGVCVCAVGYSGDDCSTRSCPSDCRGRGQCL-NGLCECDEGYSGEDCGIRRCPRDCS---QHGV 586

  Fly   506 CVEPNSCACFAGY--EDTKVPYECVPSCRPRCENGRCSSPGHCECDPGHVVTNSSEPNSCRPQCQ 568
            | :...|.|.|||  ||..: ..|...||.|   |||.. |.|.|:||:.          .|.|.
Mouse   587 C-QDGLCMCHAGYAGEDCSI-RTCPADCRRR---GRCED-GRCVCNPGYT----------GPACA 635

  Fly   569 EQCINAECVAPEKCA-----CLPRYRFLPDSSTEC---EP---ICSKG------CLSGQECV--- 613
            .:...|:|....:|.     |...|     |..:|   ||   .|..|      |.:|| ||
Mouse   636 TRTCPADCRGRGRCVQGVCMCYVGY-----SGEDCGQEEPPASACPGGCGPRELCRAGQ-CVCVE 694

  Fly   614 ---APD----TCAG 620
               .||    ||.|
Mouse   695 GFRGPDCAIQTCPG 708

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NimC2	NP_001285922.1	None
Tnxb	XP_006525248.1	EGF_2	172..200	CDD:285248	8/32 (25%)
		EGF_2	203..231	CDD:285248	10/28 (36%)
		EGF_Tenascin	236..262	CDD:376143	11/29 (38%)
		EGF_Tenascin	267..293	CDD:376143	9/31 (29%)
		EGF_Tenascin	298..325	CDD:376143	10/27 (37%)
		EGF_Tenascin	329..356	CDD:376143	7/26 (27%)
		EGF_Tenascin	360..386	CDD:376143	10/32 (31%)
		EGF_2	389..417	CDD:285248	9/28 (32%)
		EGF_Tenascin	422..448	CDD:376143	12/37 (32%)
		EGF_2	451..479	CDD:285248	8/30 (27%)
		EGF_2	482..510	CDD:285248	10/33 (30%)
		DSL	<498..541	CDD:366627	8/48 (17%)
		EGF_2	541..572	CDD:285248	11/31 (35%)
		EGF_Tenascin	577..604	CDD:376143	11/30 (37%)
		EGF_2	608..634	CDD:285248	13/39 (33%)
		EGF_Tenascin	639..665	CDD:376143	6/30 (20%)
		EGF_Tenascin	706..732	CDD:376143	2/3 (67%)
		fn3	737..818	CDD:365830
		fn3	830..906	CDD:365830
		fn3	1074..1142	CDD:365830
		fn3	1295..1369	CDD:365830
		FN3	1386..1466	CDD:238020
		fn3	1484..1558	CDD:365830
		fn3	1599..1674	CDD:365830
		fn3	1707..1782	CDD:365830
		fn3	1804..1874	CDD:365830
		fn3	1904..1971	CDD:365830
		fn3	2000..2067	CDD:365830
		fn3	2102..2164	CDD:365830
		FN3	2211..2279	CDD:238020
		fn3	2315..2393	CDD:365830
		fn3	2426..2496	CDD:365830
		fn3	2525..2600	CDD:365830
		fn3	2639..2709	CDD:365830
		fn3	2748..2823	CDD:365830
		fn3	2861..2931	CDD:365830
		fn3	2970..3043	CDD:365830
		fn3	3076..3146	CDD:365830
		fn3	3183..3258	CDD:365830
		fn3	3291..3361	CDD:365830
		fn3	3387..3462	CDD:365830
		fn3	3480..3542	CDD:365830
		fn3	3569..3649	CDD:365830
		fn3	3679..3752	CDD:365830
		fn3	3776..3855	CDD:365830
		fn3	3875..3953	CDD:365830
		FN3	3962..4048	CDD:238020
		fn3	4052..4129	CDD:365830
		Fibrinogen_C	4143..4352	CDD:278572
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910