DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NimC2 and Megf10

DIOPT Version :9

Sequence 1:	NP_001285922.1	Gene:	NimC2 / 34818	FlyBaseID:	FBgn0028939	Length:	701	Species:	Drosophila melanogaster
Sequence 2:	NP_001001979.1	Gene:	Megf10 / 70417	MGIID:	2685177	Length:	1147	Species:	Mus musculus

Alignment Length:	932	Identity:	226/932 - (24%)
Similarity:	315/932 - (33%)	Gaps:	360/932 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 CCDGYIRDENNECVPLCNDCGASGKCLLPNVCLCGKGY-----VSRKDHGHCEPECSE--SCVNG 122
            ||.|:. :..:.|||.|.|....|:|:.||.|.|..|:     .|..|..|..|.||.  .|.|.
Mouse    94 CCPGFY-ESRDMCVPHCADKCVHGRCIAPNTCQCEPGWGGTNCSSACDGDHWGPHCSSRCQCKNR 157

  Fly   123 KCVAP--DECECLAGHRFVNGSQTACEPICVE-----------DCANGRCLE--TGKCLCNNGYQ 172
            ....|  ..|.|.||:|     ...||..|.:           .|.||...:  ||:|.|:.||.
Mouse   158 ALCNPITGACHCAAGYR-----GWRCEDRCEQGTYGNDCHQRCQCQNGATCDHITGECRCSPGYT 217

  Fly   173 RDEKLKKCVP-----------ICQD--ACYH--GDCVAPN----------------------ECR 200
            .......|.|           .||:  .|:|  |:|..|:                      ||:
Mouse   218 GAFCEDLCPPGKHGPHCEQRCPCQNGGVCHHVTGECSCPSGWMGTVCGQPCPEGRFGKNCSQECQ 282

  Fly   201 CHPGHEQRLGVPWICDPI-----CSSG------------------------CANG----YCQGAE 232
            ||.|        ..||..     ||.|                        |.||    :..|
Mouse   283 CHNG--------GTCDAATGQCHCSPGYTGERCQDECPVGSYGVRCAEACRCVNGGKCYHVSG-- 337

  Fly   233 VCACKMGYA------------------------HKDNTLASGCEPVCNPPCTNGTC-ISPG---- 268
            .|.|:.|::                        |.|||  ..|.|:      :|.| ..||
Mouse   338 TCLCEAGFSGELCEARLCPEGLYGIKCDKRCPCHLDNT--HSCHPM------SGECGCKPGWSGL 394

  Fly   269 HC--ACSEGHVFAEGSRHECVPSCRSGCENGYCSS-PGRCECHEGFEKTSPHRCSPTC------- 323
            :|  .||.| .:.|..:..|  ||::|.:   |.| .|||.|..||:.|.   ||..|
Mouse   395 YCNETCSPG-FYGEACQQIC--SCQNGAD---CDSVTGRCACAPGFKGTD---CSTPCPLGRYGI 450

  Fly   324 ----RPGCGQNSRCAAPD-TCACDVGYVFVNGSTTECEPFCPR-----------NCRN-GICSS- 370
                |.||..::.|:..| :|.|..|:..|     :|...||.           .|.| |.|::
Mouse   451 NCSSRCGCKNDAVCSPVDGSCICKAGWHGV-----DCSIRCPSGTWGFGCNLTCQCLNGGACNTL 510

  Fly   371 PGVCTCLEGFQ----------ALLSFYCIPVCSKTCIHGSCVAP--NECRCFTGYRPNPSLGANV 423
            .|.|||..|::          ......|...|.  |.|.....|  ..|||..|:.     |.:
Mouse   511 DGTCTCAPGWRGAKCEFPCQDGTYGLNCAERCD--CSHADGCHPTTGHCRCLPGWS-----GVH- 567

  Fly   424 CEPICSQG-----------CVHGFCIAPE--ICQCDLGFIKRWATGTCEP----H-----CPQKC 466
            |:.:|::|           |.:|...:|:  ||:|..||........|.|    |     ||| |
Mouse   568 CDSVCAEGRWGPNCSLPCYCKNGASCSPDDGICECAPGFRGTTCQRICSPGFYGHRCSQTCPQ-C 631

  Fly   467 VNS----HCLGSGVCRCYEGYKLRPGSTSICDPECQPG-----------C-RNGTCVEP--NSCA 513
            |:|    |.: :|:|.|..|:     :.::|:..|..|           | .|||| .|  .||.
Mouse   632 VHSSGPCHHI-TGLCDCLPGF-----TGALCNEVCPSGRFGKNCAGVCTCTNNGTC-NPIDRSCQ 689

  Fly   514 CFAGY--EDTKVPY-------ECVPSCRPRCENGR-CSS-PGHCECDPGHVVTNSSE-------P 560
            |:.|:  .|...|.       .|:.:|  .|.||. ||: .|.|:|.||......::       .
Mouse   690 CYPGWIGSDCSQPCPPAHWGPNCIHTC--NCHNGAFCSAYDGECKCTPGWTGLYCTQRCPLGFYG 752

  Fly   561 NSCRPQCQEQCIN-AEC-VAPEKCACLPRYRFLPDSSTECEPIC-----SKGCLSGQECVAPDTC 618
            ..|...|  ||.| |:| ....:|.|  |..|:   ...||..|     ..||....:|:...||
Mouse   753 KDCALIC--QCQNGADCDHISGQCTC--RTGFM---GRHCEQKCPAGTYGYGCRQICDCLNNSTC 810

  Fly   619 -------------------------AGFESLISPTTGKHLAFHWSMFVLAILLCLALVMIPLLVL 658
                                     .|..:.:|.|:....|..:.:..:|.::.|.||::.||.|
Mouse   811 DHITGTCYCSPGWKGARCDQAGVIIVGNLNSLSRTSTALPADSYQIGAIAGIVVLVLVVLFLLAL 875

  Fly   659 ----REMQRRRR----------------------------NGDKQSSRLIENPSYGVV------- 684
                |..|:|:.                            ||...:|....||||..:
Mouse   876 FIIYRHKQKRKESSMPAVTYTPAMRVINADYTIAETLPHSNGGNANSHYFTNPSYHTLSQCATSP 940

  Fly   685 QANSED-------TNSELGIGL 699
            ..|:.|       .|::|.:.|
Mouse   941 HVNNRDRMTIAKSKNNQLFVNL 962

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NimC2	NP_001285922.1	None
Megf10	NP_001001979.1	Necessary for interaction with AP2M1, self-assembly and formation of the irregular, mosaic-like adhesion pattern. /evidence=ECO:0000250\|UniProtKB:Q96KG7	1..857		204/825 (25%)
		EMI	32..99	CDD:284877	3/4 (75%)
		EGF_CA	281..326	CDD:304395	9/52 (17%)
		EGF_CA	542..587	CDD:304395	12/52 (23%)
		Necessary for formation of large intracellular vacuoles. /evidence=ECO:0000250\|UniProtKB:Q96KG7	945..1147		4/18 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1093..1147
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1218
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810