DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NimC2 and megf6b

DIOPT Version :9

Sequence 1:	NP_001285922.1	Gene:	NimC2 / 34818	FlyBaseID:	FBgn0028939	Length:	701	Species:	Drosophila melanogaster
Sequence 2:	XP_009304569.1	Gene:	megf6b / 557764	ZFINID:	ZDB-GENE-101112-3	Length:	1589	Species:	Danio rerio

Alignment Length:	805	Identity:	206/805 - (25%)
Similarity:	274/805 - (34%)	Gaps:	274/805 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 KHQNSANCTTN-CGPLVGRTRTETYLG----FTDVCCDGYIRDE---NNECVP-----LCND--- 83
            ||:|:.:|... .|.:...|..|.:.|    ....|.:|.:.|.   :..|.|     ||.|
Zfish   564 KHRNACDCPDGWTGVVCNETCPEGWFGRNCSLLCKCKNGGVCDPVSGSCRCPPGVSGELCQDGCP 628

  Fly    84 -------------CGASGKC-LLPNVCLCGKGYVSRKDHGHCE-----PECSESCVNGKCVAPDE 129
                         |..:|:| .....|||..|...|..|..|.     |.|||.|   :||..:.
Zfish   629 KGLYGKFCNKRCNCANNGRCHRTYGACLCDPGLYGRFCHLPCPKWMFGPGCSEEC---QCVQQNT 690

  Fly   130 CECLAGHRFVNGSQTACEP-----ICVEDCANG----RCLETGKCLCNNGYQRDEKLKKCVPICQ 185
            .||   ||  :.....|:|     .|.::|.:|    .|  ..||.|..|...|.....|.|.|.
Zfish   691 IEC---HR--HHGDCICKPGYRGHTCKDECESGFFGSAC--ENKCSCPPGVTCDHVTGACQPKCP 748

  Fly   186 -----DACYHGDCV----------------AP-----NECRCHPG----------HEQRLGV--- 211
                 |.| ..|||                ||     .:|.|..|          .|.|.|:
Zfish   749 AGKTGDKC-DQDCVEGRFGIGCSQSCDCSGAPCDKVTGQCTCPAGTFGKRCEKECPEGRWGLGCQ 812

  Fly   212 PWICDPICSSGCANGYCQGAE-VCACKMGYAHK--DNTLAS-----GCEPVCNPPCTNGTCISP- 267
            .| | |:|.:|   |.|.... .|.|..|:..:  .|:..:     ||:..|  .|..|...:|
Zfish   813 EW-C-PVCENG---GRCDRRNGTCVCSPGFIGRLCQNSCPAGRFGVGCQLRC--VCDLGVRCNPV 870

  Fly   268 -GHCACSEGHVFAEGSRHECVPSCRSG-----CE--------NGYC-SSPGRCECHEGFEKTSPH 317
             |.|:|..|     .:.|.|...|.:|     ||        :|.| :..|||.|..||   :..
Zfish   871 SGRCSCPPG-----WTGHNCRKVCDAGRWGLDCESVCDCRNADGVCDAQTGRCHCEAGF---TGA 927

  Fly   318 RCSPTC-----RPGCGQNSRC---AAPD----TCACDVGYVFVNGSTTECEPFCPRN-------- 362
            ||...|     .|||....:|   |:.|    .|.|..|:     :.|.||..||:.
Zfish   928 RCDQKCPAGSFGPGCKHRCQCENQASCDHVGGACTCKTGW-----TGTFCEKPCPQGFYGLDCQQ 987

  Fly   363 ---CRN-GICSS-PGVCTCLEGFQALLSFYCIPV------CSKTCI---HGSCVA-PNECRCFTG 412
               |.| |:|.. .|.|.|..|:.........|.      ||:||:   :.||.| ..:|.|..|
Zfish   988 KCVCLNGGLCDHVSGQCFCKAGWIGTRCNQTCPAGWFGVSCSQTCVCHNNSSCDAVSGQCECGAG 1052

  Fly   413 YRPNPSLGANVCEPIC-----SQGCVH------GFCIAPEI--CQCDLGFIKRWATGTCEPHCPQ 464
            :.      .:.|...|     ..||||      |....||.  |.|..|    |....|:..||.
Zfish  1053 WT------GDTCSQRCPAGVFGDGCVHRCLCQNGASCDPESGHCFCPSG----WTGAACQLECPA 1107

  Fly   465 -----------KCVN-SHCLG-SGVCRCYEGYKLRPGSTSICDPECQPG-----------CRNGT 505
                       :||| :.|.| :|.|.|..|:     :...|:.||:.|           |.:|.
Zfish  1108 GRFGSDCQDRCECVNGAQCDGQTGRCVCPPGW-----TGERCENECERGWFGVGCEDRCQCDHGA 1167

  Fly   506 CVE--PNSCACFAGYEDTKVPYECVP-----SCRPRCENGRCSS-------PGHCECDPGHVVTN 556
            ...  ...|.|.||:...:....|:|     .|..||.   |.|       .|||.|.||  .|.
Zfish  1168 VCHHVSGQCLCPAGWRGRRCEKACLPGSFGQDCVQRCS---CPSGSSCHHVTGHCGCAPG--FTG 1227

  Fly   557 SSEPNSCRPQCQEQCINAECVAPEK----------CACLPRYRFLPDSSTECEPICSKG------ 605
            ....:||.|....|..|..|...|:          |.|.|.:     :..:||..|.:|
Zfish  1228 DGCEHSCLPGTFGQDCNQVCQCSERNQLCHPVTGVCYCAPGF-----TGLKCEQTCPQGLYGSGC 1287

  Fly   606 -----CLSGQECVAPD-TC---AGF 621
                 ||:|..|::.. :|   |||
Zfish  1288 EHQCECLNGGVCLSDSGSCQCPAGF 1312

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID
NimC2	NP_001285922.1	None
megf6b	XP_009304569.1	EMI	33..102	CDD:284877
		FXa_inhibition	152..187	CDD:291342
		vWFA	<184..227	CDD:294047
		FXa_inhibition	234..270	CDD:291342
		FXa_inhibition	276..311	CDD:291342
		vWFA	<308..350	CDD:294047
		FXa_inhibition	363..398	CDD:291342
		vWFA	<396..436	CDD:294047
		FXa_inhibition	445..480	CDD:291342
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1218
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900