Protein Alignment NimC2 and STAB2

DIOPT Version :9

• Sequence 1: NP_001285922.1
• Gene: NimC2 / 34818
• FlyBaseID: FBgn0028939
• Length: 701
• Species: Drosophila melanogaster
• Sequence 2: NP_060034.9
• Gene: STAB2 / 55576
• HGNCID: 18629
• Length: 2551
• Species: Homo sapiens
• Alignment Length: 981
• Identity: 198/981 - (20%)
• Similarity: 267/981 - (27%)
• Gaps: 481/981 - (49%)

  Fly    46 CGPLVGRTRTETYLGFTDVCCDGYIRDENNECVPLC-----NDCGASGKCL----LPNVCLCGKG 101
            |.|...||      ..|..||.|:.   ..:|.| |     |.|..:|.||    ...||.||:|
Human  1323 CQPKCVRT------VITRECCAGFF---GPQCQP-CPGNAQNVCFGNGICLDGVNGTGVCECGEG 1377

  Fly   102 Y-------VSRKDHG-HCEPECSESCVNGKC----VAPDECECLAGHRFVNGSQTACEPICVEDC 154
            :       .:...:| ||:..|  |||:|:|    :....|:|..|.|.|:     |:....||.
Human  1378 FSGTACETCTEGKYGIHCDQAC--SCVHGRCNQGPLGDGSCDCDVGWRGVH-----CDNATTEDN 1435

  Fly   155 ANGRCLETGKCLCNNGYQRDEKLKKCVPICQDACYHGDCVAPNECRCHPGHEQRLGVPWICDPIC 219
            .||.|..:..||.|:                      |..|  .|:|..|.:   |...||..|.
Human  1436 CNGTCHTSANCLTNS----------------------DGTA--SCKCAAGFQ---GNGTICTAIN 1473

  Fly   220 SSGCANGYCQ----------GAEVCACKMGYAHKDNTLA----------SGCEPVCNPPCTNGTC 264
            :...:||.|.          |..||.||.||. .|..:.          .||:.  |..||.
Human  1474 ACEISNGGCSAKADCKRTTPGRRVCTCKAGYT-GDGIVCLEINPCLENHGGCDK--NAECTQ--- 1532

  Fly   265 ISPGHCACSEGHVFAEGSRHECVPS-------------CRSGCENGYCSSPGRCECHEG-FEKTS 315
            ..|...||:            |:|:             |.:  :||.||....|. |.| .|:|.
Human  1533 TGPNQAACN------------CLPAYTGDGKVCTLINVCLT--KNGGCSEFAICN-HTGQVERTC 1582

  Fly   316 PHRCSP-------TCRPGCGQ----NSRCA-----------------------APDTCACD---- 342
              .|.|       |||....|    |.:.:                       ||.:.|.|
Human  1583 --TCKPNYIGDGFTCRGSIYQELPKNPKTSQYFFQLQEHFVKDLVGPGPFTVFAPLSAAFDEEAR 1645

  Fly   343 -------------VGYVFV--------------NGSTTECEP----------------------- 357
                         :.|..|              |.::.:.||
Human  1646 VKDWDKYGLMPQVLRYHVVACHQLLLENLKLISNATSLQGEPIVISVSQSTVYINNKAKIISSDI 1710

  Fly   358 -------------FCPRN--------------------CRNG------ICSSPGVCTCL------ 377
                         ..|:|                    ..||      :....|:.:.:
Human  1711 ISTNGIVHIIDKLLSPKNLLITPKDNSGRILQNLTTLATNNGYIKFSNLIQDSGLLSVITDPIHT 1775

  Fly   378 ---------EGFQAL--------------------LSFYCI----------PVCS--KTCIHGS- 400
                     :...||                    |.|:.|          |..:  || :.||
Human  1776 PVTLFWPTDQALHALPAEQQDFLFNQDNKDKLKEYLKFHVIRDAKVLAVDLPTSTAWKT-LQGSE 1839

  Fly   401 ----CVAPNE----------------------------------------CRCFTGYRPNPSLGA 421
                |.|..:                                        |..||.:..:...|:
Human  1840 LSVKCGAGRDIGDLFLNGQTCRIVQRELLFDLGVAYGIDCLLIDPTLGGRCDTFTTFDASGECGS 1904

  Fly   422 NVCEPIC---------SQGCVH------------------------------------------- 434
            .|..|.|         .|.|::
Human  1905 CVNTPSCPRWSKPKGVKQKCLYNLPFKRNLEGCRERCSLVIQIPRCCKGYFGRDCQACPGGPDAP 1969

  Fly   435 ----GFCI----APEICQCDLGFIKRWATGT-CE--------PHC-PQKCV-NSHC----LGSGV 476
                |.|:    |...|:|:.||     .|| ||        |.| |..|. :..|    .|||.
Human  1970 CNNRGVCLDQYSATGECKCNTGF-----NGTACEMCWPGRFGPDCLPCGCSDHGQCDDGITGSGQ 2029

  Fly   477 CRCYEGYKLRPGSTSICDPE------CQPGC-RNGTCVEPNSCACFAGYEDTKVPYECVPSCRPR 534
            |.|..|:     :...||.:      |.|.| .:.||.|.|:|.|...||...:....|..|:.
Human  2030 CLCETGW-----TGPSCDTQAVLPAVCTPPCSAHATCKENNTCECNLDYEGDGITCTVVDFCKQ- 2088

  Fly   535 CENG------RCSSPG---HCECDPGHVVTNSSEPNSC----------RPQCQEQCINAEC--VA 578
             :||      |||..|   .|.|..|:    ..:.:||          ...|.|   :|.|  ..
Human  2089 -DNGGCAKVARCSQKGTKVSCSCQKGY----KGDGHSCTEIDPCADGLNGGCHE---HATCKMTG 2145

  Fly   579 P--EKCACLPRYRFLPDSSTECEP--------ICSKG-CLSGQECV---APDTCAGFESLISPTT 629
            |  .||.|...|   ......|||        :...| |.:..:||   ..||..|...|.||..
Human  2146 PGKHKCECKSHY---VGDGLNCEPEQLPIDRCLQDNGQCHADAKCVDLHFQDTTVGVFHLRSPLG 2207

  Fly   630 GKHLAF 635
            ...|.|
Human  2208 QYKLTF 2213

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NimC2	NP_001285922.1	None
STAB2	NP_060034.9	EGF_3	246..275	CDD:289699
		EGF_3	326..361	CDD:289699
		Fasciclin	382..505	CDD:280607
		Fasciclin	526..654	CDD:280607
		EGF_3	837..865	CDD:289699
		EGF_3	920..951	CDD:289699
		EGF_3	957..993	CDD:289699
		Fasciclin	1009..1129	CDD:280607
		Fasciclin	1148..1265	CDD:280607
		EGF_3	1437..1469	CDD:289699	12/58 (21%)
		EGF_3	1475..1511	CDD:289699	11/36 (31%)
		EGF_3	1517..1553	CDD:289699	10/52 (19%)
		EGF_3	1559..1595	CDD:289699	12/40 (30%)
		Fasciclin	1617..1726	CDD:280607	9/108 (8%)
		Fasciclin	1752..1882	CDD:280607	14/130 (11%)
		EGF_3	2086..2121	CDD:289699	10/40 (25%)
		EGF_3	2127..2164	CDD:289699	9/42 (21%)
		Link_domain_TSG_6_like	2198..2290	CDD:239592	6/16 (38%)
		FAS1	2356..2449	CDD:214719
		Interaction with TMSB4X. /evidence=ECO:0000269|PubMed:18519035	2504..2514
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2512..2551

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1218
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810