Protein Alignment NimC2 and PEAR1

DIOPT Version :10

• Sequence 1: NP_788047.1
• Gene: NimC2 / 34818
• FlyBaseID: FBgn0028939
• Length: 701
• Species: Drosophila melanogaster
• Sequence 2: XP_016856723.1
• Gene: PEAR1 / 375033
• HGNCID: 33631
• Length: 1125
• Species: Homo sapiens
• Alignment Length: 1000
• Identity: 223/1000 - (22%)
• Similarity: 303/1000 - (30%)
• Gaps: 437/1000 - (43%)

  Fly    10 SGLQVQG-----------CVKQAQVVKMRGT-------LVTMRKHQNSANCTTNCGPLVGRTRTE 56
            :|.|.:|           |:..||:...|.:       |.|:|:     :|   |.||
Human    20 AGAQSKGPEDTGPQSGLFCMPTAQISADRSSRLLAAAPLPTLRR-----SC---CRPL------- 69

  Fly    57 TYLGFTDVCCDGYIRDENNECVPLCND-------CG-------------ASGKCLLP-------- 93
                               :|..||..       ||             ||||..||
Human    70 -------------------QCHRLCVPSFSWLWACGWLELSTPVIPIPAASGKASLPPPRSPTPA 115

  Fly    94 ----------------------------------NVCLCGKGYVSR--------KDH-------- 108
                                              :.|:...|.|.|        .||
Human   116 PSACSPQSPASGPGRAPILAPSPQTQRKLLASRDSFCMVCVGVVYRTVYRQVVKTDHRQRLQCCH 180

  Fly   109 ------GHCEPECSESCVNGKCVAPDECECLAGHRFVNGSQTACE-------PICVEDCA---NG 157
                  |.|.|.|::.||:|:||||::|:|:.|.|   |...:.|       |.|.:.|:   |.
Human   181 GFYESRGFCVPLCAQECVHGRCVAPNQCQCVPGWR---GDDCSSECAPGMWGPQCDKPCSCGNNS 242

  Fly   158 RC-LETGKCLCNNGYQRDEKLKKCV-----PICQDACY-HGDCVAP--NECRCHPGHEQRLGVPW 213
            .| .::|.|.|.:|.|....|:.|.     |.||..|. ||....|  ..|.| |.  :|.|..
Human   243 SCDPKSGVCSCPSGLQPPNCLQPCTPGYYGPACQFRCQCHGAPCDPQTGACFC-PA--ERTGPS- 303

  Fly   214 ICDPICSSGCANGYCQGAEVCACKMGYAHKDNTLASGCEP-----VCNPPCTNG----TCIS--- 266
             ||..||.|.:..:|....  :|:.|...:....:..|.|     :|:.||..|    .|..
Human   304 -CDVSCSQGTSGFFCPSTH--SCQNGGVFQTPQGSCSCPPGWMGTICSLPCPEGFHGPNCSQECR 365

  Fly   267 ----------PGHCACSEGHVFAEGSRHECVPSCRSG-----------------------CENGY 298
                      .|.|.|:.|:. .:..|.|| |..|.|                       ||:|:
Human   366 CHNGGLCDRFTGQCRCAPGYT-GDRCREEC-PVGRFGQDCAETCDCAPDARCFPANGACLCEHGF 428

  Fly   299 ------------------CSSP---------------GRCECHEGFEKTSPHRCSPTC-----RP 325
                              |.:|               |.|.|..|:   :...|:.:|     .|
Human   429 TGDRCTDRLCPDGFYGLSCQAPCTCDREHSLSCHPMNGECSCLPGW---AGLHCNESCPQDTHGP 490

  Fly   326 GCGQNSRC-------AAPDTCACDVGYVFVNGSTTECEPFCPR-----------NCRNGICSSP- 371
            ||.::..|       |....|.|..||     :...|...||.           :|.|.|..||
Human   491 GCQEHCLCLHGGVCQATSGLCQCAPGY-----TGPHCASLCPPDTYGVNCSARCSCENAIACSPI 550

  Fly   372 -GVCTCLEGFQ----------ALLSFYCIPVCSKTCIHGSCVAP--NECRCFTGYR--------P 415
             |.|.|.||:|          ....|.|...|.  |.|.:..:|  ..|.|..|:.        |
Human   551 DGECVCKEGWQRGNCSVPCPPGTWGFSCNASCQ--CAHEAVCSPQTGACTCTPGWHGAHCQLPCP 613

  Fly   416 NPSLG---ANVCEPICSQGC--VHGFCIAPEICQCDLGFIKRWATGTCEPHCPQKCVNSHCLGSG 475
            ....|   |:.|:...|.||  |||      .|||..|    |....|...||:.....:|  |.
Human   614 KGQFGEGCASRCDCDHSDGCDPVHG------RCQCQAG----WMGARCHLSCPEGLWGVNC--SN 666

  Fly   476 VCRCYEGYKLRP-GSTSICDP---------ECQPG----------CRNGTCVEPN--SCACFAGY 518
            .|.|..|....| ....:|.|         .||||          |.|.:...|:  :|.|.||:
Human   667 TCTCKNGGTCLPENGNCVCAPGFRGPSCQRSCQPGRYGKRCVPCKCANHSFCHPSNGTCYCLAGW 731

  Fly   519 EDTKVPYECVPSCRPRCENGRCSSPGH--------CECDPGHVVTNSSEPNSCRPQ--------- 566
            ..        |.|...|      .|||        |:|..|         .:|.||
Human   732 TG--------PDCSQPC------PPGHWGENCAQTCQCHHG---------GTCHPQDGSCICPLG 773

  Fly   567 -----CQEQC----INAECVAPEKCACLPRYRFLPDSSTECEPICSKGCLSGQEC---------V 613
                 |.|.|    ..|.|..|  |.|.|..:..|::.. |  :|..| .||..|         |
Human   774 WTGHHCLEGCPLGTFGANCSQP--CQCGPGEKCHPETGA-C--VCPPG-HSGAPCRIGIQEPFTV 832

  Fly   614 APDTCAGFESLISPTTGKHLAFHWSMFVLAILLCLALVMIPLLV-LREMQR-------------R 664
            .|.|...:.||            .::..:|:|..|.:.::.|.: .|..|:             .
Human   833 MPTTPVAYNSL------------GAVIGIAVLGSLVVALVALFIGYRHWQKGKEHHHLAVAYSSG 885

  Fly   665 RRNGDK--------QSSRLIENPSY 681
            |.:|.:        ..|....||||
Human   886 RLDGSEYVMPDVPPSYSHYYSNPSY 910