DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NimC2 and TNC

DIOPT Version :9

Sequence 1:	NP_001285922.1	Gene:	NimC2 / 34818	FlyBaseID:	FBgn0028939	Length:	701	Species:	Drosophila melanogaster
Sequence 2:	XP_016870167.1	Gene:	TNC / 3371	HGNCID:	5318	Length:	2384	Species:	Homo sapiens

Alignment Length:	718	Identity:	194/718 - (27%)
Similarity:	272/718 - (37%)	Gaps:	193/718 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 GCVKQAQVVKMRGTLVTMRKHQNS--ANCTTNCG----PLVGRTRTETYLGFTDVCCD--GYIRD 72
            ||.....|.::...|..:....:|  ..||...|    |..||..|..:       |.  |....
Human   112 GCAAAPDVKELLSRLEELENLVSSLREQCTAGAGCCLQPATGRLDTRPF-------CSGRGNFST 169

  Fly    73 ENNECV-------PLCND------CGASGKCLLPNVCLCGKGYVSRKDHGH--CEPECSE--SCV 120
            |...||       |.|::      |...|:| :...|:|..|:.. :|...  |..:|::  .||
Human   170 EGCGCVCEPGWKGPNCSEPECPGNCHLRGRC-IDGQCICDDGFTG-EDCSQLACPSDCNDQGKCV 232

  Fly   121 NGKCVAPDECECLAGHRFVNGSQTACEPICVEDCANGRCLETGKCLCNNGYQRDEKLKKCVPICQ 185
            ||.|:      |..|:...:.|:..|...|.|:  :|.|:: |.|:|::|:..|:..|   |:|.
Human   233 NGVCI------CFEGYAGADCSREICPVPCSEE--HGTCVD-GLCVCHDGFAGDDCNK---PLCL 285

  Fly   186 DACYH-GDCVAPNECRCHPGHEQRLGVPWICDPIC--SSGCANGYCQGAEVCACKMGYAHKDNTL 247
            :.||: |.|| .|||.|..|.........||...|  ...|.||      .|.|:.|:..:|
Human   286 NNCYNRGRCV-ENECVCDEGFTGEDCSELICPNDCFDRGRCING------TCYCEEGFTGED--- 340

  Fly   248 ASGC-EPVCNPPC-TNGTCISPGHCACSEGHVFAEGSRHECVPSCRSGCENGYCSSPGRCECHEG 310
               | :|.|...| |.|.| ..|.|.|.||....:.|...|...|.:   .|.|.. |||||.:|
Human   341 ---CGKPTCPHACHTQGRC-EEGQCVCDEGFAGVDCSEKRCPADCHN---RGRCVD-GRCECDDG 397

  Fly   311 FEKTSPHRCSP-TCRPGCGQNSRCAAPDTCACDVGYVFVNGSTTECEPF-CPRNCRN-GICSSPG 372
            |....   |.. .|..||..:.|| ....|.||.||     :..:|... ||.:|.: |.|.. |
Human   398 FTGAD---CGELKCPNGCSGHGRC-VNGQCVCDEGY-----TGEDCSQLRCPNDCHSRGRCVE-G 452

  Fly   373 VCTCLEGFQALLSFYCIPVCSKTCIHGSCVAPNECRCFTGYRPNPSLGANVCEPICSQG-CVHGF 436
            .|.|.:||:..           .|...||  ||:|.                    ..| ||:|.
Human   453 KCVCEQGFKGY-----------DCSDMSC--PNDCH--------------------QHGRCVNGM 484

  Fly   437 CIAPEICQCDLGFIKRWATG-TC-EPHCPQKCVNSHCLGSGVCRCYEGYKLRPGSTSICDPEC-- 497
            |:      ||.|:     || .| :..||:.|.|......|.|.|.:|:.....:...|..:|
Human   485 CV------CDDGY-----TGEDCRDRQCPRDCSNRGLCVDGQCVCEDGFTGPDCAELSCPNDCHG 538

  Fly   498 QPGCRNGTCVEPNSCACFAGY--EDTKVPYECVPSCRPRCENGRCSSPGHCECDPGHVVTNSSEP 560
            |..|.||.||      |..|:  :|.| ...|...|..:   |||.. |.|.|..|....:..:
Human   539 QGRCVNGQCV------CHEGFMGKDCK-EQRCPSDCHGQ---GRCVD-GQCICHEGFTGLDCGQ- 591

  Fly   561 NSCRPQCQE--QCINAECVAPEKCACLPRYRFLPDSSTECEPICSKGCLSGQEC--VAPDTCAGF 621
            :||...|..  ||::..|                        ||::| .||::|  |:|..
Human   592 HSCPSDCNNLGQCVSGRC------------------------ICNEG-YSGEDCSEVSPPK---- 627

  Fly   622 ESLISPTTGKHLAFHW--SMFVLAILLCLALVMIPL----LVLREMQRRRRNGDKQSSRLIENPS 680
            :.:::..|.:.:...|  .|.|...|    :|..|.    |   ||| .|..|| |:|.:|:...
Human   628 DLVVTEVTEETVNLAWDNEMRVTEYL----VVYTPTHEGGL---EMQ-FRVPGD-QTSTIIQELE 683

  Fly   681 YGV 683
            .||
Human   684 PGV 686

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NimC2	NP_001285922.1	None
TNC	XP_016870167.1	EGF_2	377..403	CDD:285248	11/32 (34%)
		EGF_2	408..434	CDD:285248	10/31 (32%)
		EGF_2	468..496	CDD:285248	15/60 (25%)
		EGF_2	504..527	CDD:285248	6/22 (27%)
		EGF_2	533..558	CDD:285248	9/30 (30%)
		fn3	624..695	CDD:306538	20/76 (26%)
		fn3	713..793	CDD:306538
		fn3	804..884	CDD:306538
		fn3	894..976	CDD:306538
		fn3	986..1064	CDD:306538
		fn3	1075..1154	CDD:306538
		fn3	1169..1241	CDD:306538
		fn3	1260..1327	CDD:306538
		fn3	1348..1427	CDD:306538
		fn3	1439..1508	CDD:306538
		fn3	1533..1605	CDD:306538
		fn3	1619..1691	CDD:306538
		fn3	1716..1788	CDD:306538
		fn3	1804..1883	CDD:306538
		fn3	1894..1973	CDD:306538
		fn3	1985..2055	CDD:306538
		fn3	2071..2143	CDD:306538
		Fibrinogen_C	2163..2372	CDD:278572
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910