DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NimC2 and Pear1

DIOPT Version :9

Sequence 1:	NP_001285922.1	Gene:	NimC2 / 34818	FlyBaseID:	FBgn0028939	Length:	701	Species:	Drosophila melanogaster
Sequence 2:	NP_001128431.1	Gene:	Pear1 / 295293	RGDID:	1305653	Length:	1033	Species:	Rattus norvegicus

Alignment Length:	810	Identity:	195/810 - (24%)
Similarity:	265/810 - (32%)	Gaps:	294/810 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    93 PNVCLCGKGYVSRKDHGHCEPECSESCVNGKCVAPDECECLAGHRFVNGSQTA--------CEPI 149
            |.:..||..|.|   .|.|.|.|::.||:|:||||:.|:|..|.|..:.|...        |:.:
  Rat    84 PRLQCCGGYYES---SGACVPLCAQECVHGRCVAPNRCQCAPGWRGDDCSSECAPGMWGPQCDRL 145

  Fly   150 CVEDCANGRCLE--TGKCLCNNGYQRDEKLKKCV-----PICQDACY-HGDCVAPNE--CRCHPG 204
            |:  |.|....:  :|.|.|.:|.|..:.|:.|.     |.||..|: :|....|.:  |.|.||
  Rat   146 CL--CGNSSSCDPRSGVCFCPSGLQPPDCLQPCPDGHYGPACQFDCHCYGASCDPRDGACFCPPG 208

  Fly   205 HEQRLGVPWICDPICSSGCANGYCQGAEVCACKMGYAHKDNTLASGCEP-----VCNPPCTNG-- 262
               |.|..  |:..||.|....:|  .....|:.|...:.:..:..|.|     :|:.||..|
  Rat   209 ---RTGPS--CNVPCSQGTDGFFC--PRTYPCQNGGVPQGSQGSCSCPPGWMGVICSLPCPEGFH 266

  Fly   263 --TCIS-------------PGHCACSEGHVFAEGSRHEC-----------VPSCRSG-------- 293
              .|..             .|.|.|:.|:: .:..|.||           ...|..|
  Rat   267 GPNCTQECRCHNGGLCDRFTGQCHCAPGYI-GDRCREECPVGRFGQDCAETCDCAPGARCFPANG 330

  Fly   294 ---CENGY------------------CSSP---------------GRCECHEGFEKTSPHRCSPT 322
               ||:|:                  |..|               |.|.|..|:   :...|:.:
  Rat   331 ACLCEHGFTGDRCTERLCPDGRYGLSCQDPCTCDPEHSLSCHPMHGECSCQPGW---AGLHCNES 392

  Fly   323 C-----RPGCGQNSRC-------AAPDTCACDVGYVFVNGSTTECEPFCPRN-----------CR 364
            |     ..||.::..|       |....|.|..||     :...|...||.|           |.
  Rat   393 CPQDTHGAGCQEHCLCLHGGVCLADSGLCRCAPGY-----TGPHCANLCPPNTYGINCSSHCSCE 452

  Fly   365 NGICSSP--GVCTCLEGFQ----------ALLSFYCIPVCSKTCIHGSCVAP--NECRCFTGYR- 414
            |.|..||  |.|.|.||:|          ....|.|...|.  |.|....:|  ..|.|..|:|
  Rat   453 NAIACSPVDGTCICKEGWQRGNCSVPCPPGTWGFSCNASCQ--CAHEGVCSPQTGACTCTPGWRG 515

  Fly   415 -------PNPSLG---ANVCEPICSQGC--VHGFCIAPEICQCDLGFIKRWATGTCEPHCPQKCV 467
                   |....|   |:||:...|.||  |||.      |:|..|    |....|...||:...
  Rat   516 VHCQLPCPKGQFGEGCASVCDCDHSDGCDPVHGH------CRCQAG----WMGTRCHLPCPEGFW 570

  Fly   468 NSHCLGSGVCRCYEGYKLRPGSTSICDPE-----CQPGCRNGTCVEP------------------ 509
            .::|  |..|.|..|        ..|.||     |.||.|..:|..|
  Rat   571 GANC--SNACTCKNG--------GTCVPENGNCVCAPGFRGPSCQRPCPPGRYGKRCVPCKCNNH 625

  Fly   510 -------NSCACFAGYEDTKVPYECVPSCRP-----------RCENGRCSSP--GHCECDPGHVV 554
                   .:|:|.||:...    :|..||.|           :|.:|....|  |.|.|.||...
  Rat   626 SSCHPSDGTCSCLAGWTGP----DCSESCPPGHWGLKCSQPCQCHHGATCHPQDGSCVCIPGRTG 686

  Fly   555 TNSSE--PN-----SCRPQCQEQCINAECVAPEKCACLPRYRFLPDSSTECEPICSKGCLSGQEC 612
            .|.||  |:     :|...|  ||...|...||..||                :|..| .||..|
  Rat   687 PNCSEGCPSRMFGVNCSQLC--QCDPGEMCHPETGAC----------------VCPPG-HSGAHC 732

  Fly   613 VAPDTCAGFESL-ISPTTGKHLAFHWSM---FVLAILLCLALVMIPLLV-LREMQRRRRNG---- 668
                .....||. |.||:.   ..|.|:   ..:|:|..|.:.::.|.: .|..|:.:.:.
  Rat   733 ----KVGSQESFTIMPTSP---VIHNSLGAVIGIAVLGTLVVALVALFIGYRHWQKGKEHEHLAV 790

  Fly   669 -----------------DKQSSRLIENPSY 681
                             ....|....||||
  Rat   791 AYSTGRLDGSDYVMPDVSPSYSHYYSNPSY 820

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NimC2	NP_001285922.1	None
Pear1	NP_001128431.1	EMI	25..93	CDD:284877	3/8 (38%)
		EGF_CA	535..580	CDD:304395	17/56 (30%)
		Laminin_EGF	620..665	CDD:278482	8/48 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1218
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900