DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NimC2 and Vwde

DIOPT Version :9

Sequence 1:	NP_001285922.1	Gene:	NimC2 / 34818	FlyBaseID:	FBgn0028939	Length:	701	Species:	Drosophila melanogaster
Sequence 2:	NP_001355800.1	Gene:	Vwde / 232585	MGIID:	2685313	Length:	1773	Species:	Mus musculus

Alignment Length:	685	Identity:	174/685 - (25%)
Similarity:	240/685 - (35%)	Gaps:	216/685 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 GPLVGRTRTETYLGFT----DVCCDGYIRDENNECVPL------CNDCGASGKCLLPN------- 94
            |.|..:|.::|...||    |.|       |....|.:      | ||...|.| :|:
Mouse  1145 GLLTWKTESQTPQTFTLRLKDDC-------EAKSTVTVEVTVKSC-DCLNGGSC-VPDRKFPPGS 1200

  Fly    95 ---VCLCGKGYVSRKDHGH-CEPEC----SESCVNGKCVAPD---ECEC---LAGHRFVNGSQTA 145
               :|.|..|:     :|. ||.|.    |..|..|||:...   .|:|   |.|..
Mouse  1201 GAYLCDCLPGF-----YGDLCESEARECQSNPCGLGKCIRGSHSYSCDCPPELTGKN-------- 1252

  Fly   146 CEPICVEDCANGRCLETGKCL----------CNNGYQRDEKLKKCVPICQDACYHGDCVAPNECR 200
            ||. .|::|.:..|....:|:          |..|:|.|.      ..|.|..:....:.|  ..
Mouse  1253 CEK-DVDECESWPCFPGLECINVFGSYHCGPCPEGFQGDG------TTCNDLSFQPPSMEP--LL 1308

  Fly   201 CHPGHEQR-----------LGVPWICDPICSSGCANGYCQGAEVCACKMGYAHKDNTLASGCEPV 254
            .:|...||           :|...:.....::...||          |.|.:|:..|. ...:.|
Mouse  1309 TNPSFTQRPATTFNEFLNSIGASHLSVKSVTTQMDNG----------KKGVSHQTPTY-EYVDHV 1362

  Fly   255 CNP---------PCTNGT--CISP------------------GHCACSEGHVFAEGSRHECVPSC 290
            .:|         |..||:  .|:|                  |..:......|...|..|.:...
Mouse  1363 LSPDLTVDELEVPAHNGSFASINPNNSFDQVDPVQSTFPTETGGLSTQISKPFQNFSGQEFISLT 1427

  Fly   291 RSGC------ENGYCSSPGRC---ECHEG---FEKTSPH---------------RCSPTCRPGCG 328
            ..|.      :|| .:....|   .|.:|   ...|..|               .|...||..||
Mouse  1428 TKGAITTLPEKNG-STKISNCIESSCFQGVSCVSTTGGHFKCGRCPFGYYGDGITCRAFCRHSCG 1491

  Fly   329 QNSRCAAPDTCACDVGYVFVNGSTTECEPFCPRNCRNGICSSPGVCTCLEGFQALLSFYCIPVCS 393
            :|..|.||:||.|..||   .||          ||:..||.                    |||.
Mouse  1492 RNRECVAPNTCKCKPGY---TGS----------NCQTAICH--------------------PVCK 1523

  Fly   394 KTCIHGSCVAPNECRCFTGYRPNPSLGANVCEPICSQGCVH-GFCIAPEICQCDLGFI-KRWATG 456
            |   ||.|:.||.|.|..|:.     ||...|..||..|.| |.|::..:|.|..||: .|..|.
Mouse  1524 K---HGKCIKPNICACPPGHG-----GATCDEEHCSPPCEHGGTCLSGNLCTCPYGFVGPRCETL 1580

  Fly   457 TCEPHCPQKCVNSHCLGSGVCRCYEGYKLRPGSTSICDPECQPGCRNGTCVEPNSCACFAGYEDT 521
            .|..||..   ...|:...:|:|..|:.....||::|||.|..|   |:|.:||:|.|..|:..|
Mouse  1581 VCNRHCEN---GGECVAPDICQCKSGWYGPTCSTALCDPICLNG---GSCYKPNTCLCPGGFFGT 1639

  Fly   522 KVPYECVPS-CRPRCEN-GRCSSPGHCECDPGHVVTNSSEPNSCRPQCQEQCINAECVAPEKCAC 584
                :|..: |.|.|:| |.|.....|.| ||.......:.:.|.|.|..   ..:||.|..|:|
Mouse  1640 ----QCQNAVCHPPCKNGGLCMRNNVCSC-PGGYTGKRCQTSICEPMCMN---GGKCVGPNICSC 1696

  Fly   585 LPRYRFLPDSSTECE-PICSKGCLSGQECVAPDTC 618
            ...:     |..:|. |||.:.|.:|.||:||..|
Mouse  1697 ASGW-----SGKQCNTPICLQKCKNGGECIAPSMC 1726

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NimC2	NP_001285922.1	None
Vwde	NP_001355800.1	VWD	436..588	CDD:321964
		EGF_CA	1222..1254	CDD:238011	9/39 (23%)
		EGF_CA	1256..1294	CDD:214542	8/43 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R9097
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.030