Protein Alignment NimC2 and Megf6

DIOPT Version :10

• Sequence 1: NP_788047.1
• Gene: NimC2 / 34818
• FlyBaseID: FBgn0028939
• Length: 701
• Species: Drosophila melanogaster
• Sequence 2: NP_001156449.1
• Gene: Megf6 / 230971
• MGIID: 1919351
• Length: 1572
• Species: Mus musculus
• Alignment Length: 847
• Identity: 221/847 - (26%)
• Similarity: 274/847 - (32%)
• Gaps: 333/847 - (39%)

  Fly    37 QNSANCTTN--CGPLVGRTRTETYLGFTDVCCDGYIRDENNECVPLCN------DCGASGKCL-- 91
            :|...|...  |.|:.|..||:        |..||   :..:|...|.      :|..|..|:
Mouse   698 RNRCTCRPGVACDPVSGECRTQ--------CPPGY---QGEDCGQECPVGTFGVNCSGSCSCVGA 751

  Fly    92 ----LPNVCLCGKGYVSRKDHGHCEPECSE------------SCVNGKCVAPD--ECECLAGHRF 138
                :...|||..|    |....|..:|.|            :|.:|....|:  .|.||.|  |
Mouse   752 PCHRVTGECLCPPG----KTGEDCGADCPEGRWGLGCQEICPACEHGASCDPETGTCLCLPG--F 810

  Fly   139 VNGSQ-----------TACEPICVEDCAN-GRC-LETGKCLCNNGYQRDEKLKKCVPICQDACYH 190
            | ||:           |.|:..|.  ||| |.| ..||:|.|..|:....        ||.||..
Mouse   811 V-GSRCQDACPAGWFGTGCQMRCA--CANDGHCHPATGRCSCAPGWTGLS--------CQRACDS 864

  Fly   191 G----DCVAPNECRCHPGHEQRLGVPWICDPICSSGCANGYCQGAEVCACKMGYAHKDNTLASGC 251
            |    ||:.|  |.|..||.....|..:|  :|.:|.....|:.    .|:.||      ...||
Mouse   865 GHWGPDCIHP--CNCSAGHGNCDAVSGLC--LCEAGYEGPQCEQ----WCRQGY------FGPGC 915

  Fly   252 EPVCNPPCTNG-TC--ISPGHCACSEGHVFAEGS--RHECVPS------CRSGCENGYCSS---- 301
            |..|.  |.:| ||  :| |.|.|..|.   .||  .|.| |:      |.|.|.   ||:
Mouse   916 EQKCR--CEHGATCDHVS-GACTCPAGW---RGSFCEHAC-PAGFFGLDCGSACN---CSAGAPC 970

  Fly   302 ---PGRCECHEGFEKTSPHRCSPTCRP-----GCGQNSRC---AAPD----TCACDVGYVFVNGS 351
               .|.|.|..|  :..|| |:.||.|     .|.|...|   |:.|    .|.|..|::   |.
Mouse   971 DAVTGSCICPAG--RWGPH-CAQTCPPLTFGLNCSQICTCFNGASCDPVLGQCHCAPGWM---GP 1029

  Fly   352 TTECEPFCPRN-----------CRNGICSSP--GVCTCLEGFQALLSFYCIPVCSKTCI---HG- 399
            |  |...||..           ||||....|  |.|||.||:..|       .|...|:   ||
Mouse  1030 T--CLQACPAGLYGKNCQHSCLCRNGGNCDPILGQCTCPEGWTGL-------ACENECLPGHHGA 1085

  Fly   400 ------SCV-------APNECRCFTGYRPNPSLGANVCEPICSQGCVHGFCIAPEICQCDLGFIK 451
                  ||:       ....|||.||:.      .:.|:..|..|.....|  .|.|.|..|...
Mouse  1086 GCRLNCSCLNGGTCDRLTGHCRCPTGWT------GDKCQSPCVSGMFGVHC--EEHCACRKGATC 1142

  Fly   452 RWATGTC-------EPHCPQKCVNS----------HCLG-------SGVCRCYEGYKLRPGSTSI 492
            ...||.|       ..||.|.|...          ||..       ||.|.|..|: ..||
Mouse  1143 HHVTGACLCPPGWRGSHCEQACPRGWFGEACAQRCHCPPGASCHHVSGECHCPPGF-TGPG---- 1202

  Fly   493 CDPECQPGCRNGTCVEP--------------NSCACFAGYEDTKVPYECVPSCR--PRCE----- 536
            |:..||||.....|..|              .:|.|.|||..|.....| ||.|  |.||
Mouse  1203 CEQACQPGTFGKDCEHPCQCPGETWACHPASGACVCAAGYHGTDCQQRC-PSGRYGPGCEQICKC 1266

  Fly   537 -NGRCSSP--GHCECDPGHVVTNSSEPNSC-----RPQCQEQC----------INAECVAP---- 579
             ||....|  |.|.|..|.:..:.|  .:|     .|.|...|          ::..|:.|
Mouse  1267 LNGGTCDPATGACYCPAGFLGADCS--LACPQGRFGPSCAHVCTCGQGAACDPVSGTCICPPGKT 1329

  Fly   580 ------------------EKCAC---------------------------LPRYRF----LPDSS 595
                              .||||                           .|..|:    |.:.|
Mouse  1330 GGHCERGCPQDRFGKGCEHKCACRNGGLCHATNGSCSCPLGWMGPHCEHACPAGRYGAACLLECS 1394

  Fly   596 TE----CEP-----ICSKGCLSGQECVAPDTC-AGFE-------------SLISPTTGKHL---A 634
            .:    |||     :|..| ..||.|  .||| |||.             :...|.:|:.|   .
Mouse  1395 CQNNGSCEPTSGACLCGPG-FYGQAC--EDTCPAGFHGSGCQRVCECQQGAPCDPVSGRCLCPAG 1456

  Fly   635 FH 636
            ||
Mouse  1457 FH 1458

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NimC2	NP_788047.1	None
Megf6	NP_001156449.1	EMI	41..112	CDD:462204
		FXa_inhibition	126..161	CDD:464251
		vWFA	<153..201	CDD:469594
		FXa_inhibition	208..244	CDD:464251
		FXa_inhibition	250..285	CDD:464251
		vWFA	<283..324	CDD:469594
		FXa_inhibition	337..372	CDD:464251
		vWFA	<370..409	CDD:469594
		vWFA	<412..451	CDD:469594