Protein Alignment NimC2 and Megf11

DIOPT Version :10

• Sequence 1: NP_788047.1
• Gene: NimC2 / 34818
• FlyBaseID: FBgn0028939
• Length: 701
• Species: Drosophila melanogaster
• Sequence 2: NP_001395541.1
• Gene: Megf11 / 214058
• MGIID: 1920951
• Length: 1138
• Species: Mus musculus
• Alignment Length: 920
• Identity: 228/920 - (24%)
• Similarity: 310/920 - (33%)
• Gaps: 358/920 - (38%)

  Fly    65 CCDGYIRDENNE-CVPLCNDCGASGKCLLPNVCLCGKGY-----VSRKDHGHCEPECSESCVNGK 123
            ||.||.  ||.: |:|||.:....|:|:.|:.|.|..|:     .|..|..|..|.||..|
Mouse    87 CCPGYY--ENGDFCIPLCTEECMHGRCVSPDTCHCEPGWGGPDCSSGCDSEHWGPHCSNRC---- 145

  Fly   124 CVAPDECECLAGHRFVNGSQTACEPICVEDCANGRCLETGKCLCNNGYQ--RDEKL-------KK 179
                 :|:        ||:  .|.||            ||.|:|..|::  |.|:|       |.
Mouse   146 -----QCQ--------NGA--LCNPI------------TGACVCAPGFRGWRCEELCAPGTHGKG 183

  Fly   180 CVPICQDACYHGDCVAP--NECRCHPGHEQRLGVPWICDPICSSGCANGYCQGAEVCACKMGYAH 242
            |..:||  |:||....|  .||.|.||:   .||  .|:.:|..|....:|:..  |.|:.|...
Mouse   184 CQLLCQ--CHHGASCDPRTGECLCAPGY---TGV--YCEELCPPGSHGAHCELR--CPCQNGGTC 239

  Fly   243 KDNTLASGCEP-----VCNPPCTNGT----CIS-------------PGHCACSEGHVFAEGSRHE 285
            ...|....|.|     ||..||..||    |..             .|.|.|:.|:: .:..:.|
Mouse   240 HHITGECACPPGWTGAVCAQPCPPGTFGQNCSQDCPCHHGGQCDHVTGQCHCTAGYM-GDRCQEE 303

  Fly   286 C-------VPSCRSGCENGYCSSP--GRCECHEGF------EKTSPH------------------ 317
            |       :.|.|..|.||...||  |.|||..|:      |:..|.
Mouse   304 CPFGTFGFLCSQRCDCHNGGQCSPATGACECEPGYKGPSCQERLCPEGLHGPGCTLPCPCDTENT 368

  Fly   318 -RCSP-----TCRPG-----CGQN-------SRCAAPDTCACDVGYVFVNGSTT----------- 353
             .|.|     ||:||     |.::       :.|..|.||........:.||.|
Mouse   369 ISCHPVTGACTCQPGWSGHYCNESCPAGYYGNGCQLPCTCQNGADCHSITGSCTCAPGFMGEVCA 433

  Fly   354 ----------ECEPFCPRNCRNGICSSP--GVCTCLEGFQAL-LSFYCIPV------CSKTCI-- 397
                      .|...|  :|.||...||  |.|||.||:|.| .|..| |.      |::|||
Mouse   434 VPCAAGTYGPNCSSVC--SCSNGGTCSPVDGSCTCREGWQGLDCSLPC-PSGTWGLNCNETCICA 495

  Fly   398 HGSCVAP--NECRCFTGYR--------PNPSLGANV-----------CEPI-------------- 427
            :|:..:|  ..|.|..|:.        |:.:.|.|.           |:|:
Mouse   496 NGAACSPFDGSCACTPGWLGDSCELPCPDGTFGLNCSEHCDCSHADGCDPVTGHCCCLAGWTGIR 560

  Fly   428 ----CSQG-----------CVHGFCIAPE--ICQCDLGFIKRWATGTCEP----H-CPQKC-VNS 469
                |..|           |.:|...:||  .|:|..||........|.|    | |.|.| :..
Mouse   561 CDSTCPPGRWGPNCSVSCSCENGGSCSPEDGSCECAPGFRGPLCQRICPPGFYGHGCAQPCPLCV 625

  Fly   470 HCLG-----SGVCRCYEGYKLRPGSTSICDPECQPG------------CRNGTCVEP--NSCACF 515
            |..|     ||:|.|..|:     |.::|:..|..|            ..|||| .|  .||.||
Mouse   626 HSRGPCHHISGICECLPGF-----SGALCNQVCAGGHFGQDCAQLCSCANNGTC-SPIDGSCQCF 684

  Fly   516 AGYEDTKVPYECVPSCRP-----------RCENG-RCSS-PGHCECDPGHVVTNSSEPNSCRPQC 567
            .|:    :..:|..:|..           .|.|| .||: .|.|.|.||....      .|..:|
Mouse   685 PGW----IGKDCSQACPSGFWGSACFHTCSCHNGASCSAEDGACHCTPGWTGL------FCTQRC 739

  Fly   568 QE-----------QCIN-AEC-VAPEKCACLPRYRFLPDSSTECEPICSK-----GCLSGQECVA 614
            ..           ||.| |.| ....||.|...:     |...||..|:.     ||....||:.
Mouse   740 PSAFFGKDCGHICQCQNGASCDHITGKCTCRTGF-----SGRHCEQRCAPGTFGYGCQQLCECMN 799

  Fly   615 PDTC----------AGFESL-----------------ISPTTGKHLAFHWSMFVLAILLCLALVM 652
            ..||          .||:.:                 |||..|.......::..:.:||.|.:|:
Mouse   800 NATCDHVTGTCYCSPGFKGIRCDQAALMMDELNPYTKISPALGAERHSVGAVTGIVLLLFLVVVL 864

  Fly   653 IPLLVLREMQRRRRNGD-----------------------KQSS---RLIENPSYGVV------- 684
            :.|...|..:::.:..|                       .|||   :...|.||..:
Mouse   865 LGLFAWRRRRQKEKGRDLAPRVSYTPAMRMTSTDYSLSDLSQSSSHAQCFSNASYHTLACGGPAT 929

  Fly   685 -QANSEDTNS 693
             ||::.|.||
Mouse   930 SQASTLDRNS 939

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NimC2	NP_788047.1	None
Megf11	NP_001395541.1	EMI	24..93	CDD:462204	4/7 (57%)
		EGF_CA	188..233	CDD:473889	18/53 (34%)
		EGF_CA	274..319	CDD:473889	8/45 (18%)