DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment NimC2 and Y64G10A.7

DIOPT Version :9

Sequence 1:	NP_001285922.1	Gene:	NimC2 / 34818	FlyBaseID:	FBgn0028939	Length:	701	Species:	Drosophila melanogaster
Sequence 2:	NP_001255802.1	Gene:	Y64G10A.7 / 178377	WormBaseID:	WBGene00013416	Length:	1714	Species:	Caenorhabditis elegans

Alignment Length:	769	Identity:	201/769 - (26%)
Similarity:	257/769 - (33%)	Gaps:	242/769 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 CGPLVGRTRTETYLGFTDVCCD--------GYIRDENNECVPLCND-----C-GASGKCLLPNVC 96
            |.|:.|....:...|:....||        ||..::...|..:.:.     | ..:|.|    .|
Worm   837 CDPVTGDCTKKCPAGYQGNLCDQPCPAGYFGYDCEQKCSCADVASPHKSKVCHHVTGTC----TC 897

  Fly    97 LCGK-GYVSRKDHGHCEPECSE-----------SCVNG-KCVAPD-ECECLAGHRFVNGSQTA-- 145
            |.|| |.:       |:..|:.           ||||| ||...| .|.|..|......|:..
Worm   898 LPGKTGPL-------CDQSCAPNTYGPNCAHTCSCVNGAKCDESDGSCHCTPGFYGATCSEVCPT 955

  Fly   146 ------CEPICVEDCANGRCLET--GKCLCNNGYQRDEKLKKCVP-----ICQDACYHGDCV--- 194
                  |..:|  .|.||...:|  |.|.|..|:...:..|.|.|     .|...|   ||.
Worm   956 GRFGIDCMQLC--KCQNGAICDTSNGSCECAPGWSGKKCDKACAPGTFGKDCSKKC---DCADGM 1015

  Fly   195 ----APNECRCHP---GHEQRLGVPWICDPICSSGCANGYCQG-------------AEVCACKMG 239
                :..||.|.|   ||:        ||..|.||.....|:|             ...|.|:.|
Worm  1016 HCDPSDGECICPPGKKGHK--------CDETCDSGLFGAGCKGICSCQNGATCDSVTGSCECRPG 1072

  Fly   240 YAHK-------DNTLASGCEPVCNPPCTNGTCI-SP---------GHCACSEGHV---------- 277
            :..|       |.....||..:|:...||.|.: :|         |.|.|..|..
Worm  1073 WRGKKCDRPCPDGRFGEGCNAICDCTTTNDTSMYNPFVARCDHVTGECRCPAGWTGPDCQTSCPL 1137

  Fly   278 --FAEGSRHECVPSCRSGCE--NGYCSSPG-----RC--ECHEGFEKTSPHRCSPTCRPGCGQNS 331
              ..||.||.|..|..:.|:  .|:|..|.     .|  ||.||...::   |...|.  |....
Worm  1138 GRHGEGCRHSCQCSNGASCDRVTGFCDCPSGFMGKNCESECPEGLWGSN---CMKHCL--CMHGG 1197

  Fly   332 RCAAPD-TCACDVGYVFVNGST-TECEPFCP-----------RNCRNGI-CS-SPGVCTCLEGFQ 381
            .|...: .|.|      ::|.| ..||..||           .||:||. |. ..|.|.||.|:.
Worm  1198 ECNKENGDCEC------IDGWTGPSCEFLCPFGQFGRNCAQRCNCKNGASCDRKTGRCECLPGWS 1256

  Fly   382 ALLSFYCIPVCSKTCIHGSCVAPNE--CRCFTGYRPNPSLGANVCEP-----ICSQGCVHGF--- 436
            .       ..|.|:|:.|...|..|  |.|..|...:|..|...|:|     .|::.|:.|:
Worm  1257 G-------EHCEKSCVSGHYGAKCEETCECENGALCDPISGHCSCQPGWRGKKCNRPCLKGYFGR 1314

  Fly   437 -------CIAPEI-------CQCDLGFIKRWAT-----GTCEPHCPQKC---VNSHCLG-SGVCR 478
                   |...:.       |||..|:.....|     ||....|.|||   .||.|.. ||.|.
Worm  1315 HCSQSCRCANSKSCDHISGRCQCPKGYAGHSCTELCPDGTFGESCSQKCDCGENSMCDAISGKCF 1379

  Fly   479 CYEGYKLRPGSTSICDPECQPG-----------CRNGTCVEPN--SCACFAGYEDTKVPYECV-- 528
            |..|:     |.|.|...|..|           |.||...:.:  ||.|..||..||....|.
Worm  1380 CKPGH-----SGSDCKSGCVQGRFGPDCNQLCSCENGGVCDSSTGSCVCPPGYIGTKCEIACQSD 1439

  Fly   529 ---PSCRP--RCEN-GRCSS-PGHCECDPGHVVTNSSEPNSCRPQCQEQCINAECVAPEKCACLP 586
               |:|..  .||| |.|.. .|.|.|.||..      ..:|...|.|....|.|  .|||.|..
Worm  1440 RFGPTCEKICNCENGGTCDRLTGQCRCLPGFT------GMTCNQVCPEGRFGAGC--KEKCRCAN 1496

  Fly   587 RYRFLPDSSTECE-------PICSKGCLSGQ---ECVAPDTCAGFESLISPTTG 630
            .:  ...||.||:       |.|.:.|.||:   .|.....|.| ::...|..|
Worm  1497 GH--CNASSGECKCNLGFTGPSCEQSCPSGKYGLNCTLDCECYG-QARCDPVQG 1547

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID
NimC2	NP_001285922.1	None
Y64G10A.7	NP_001255802.1	EMI	35..105	CDD:284877
		FXa_inhibition	159..194	CDD:291342
		FXa_inhibition	200..235	CDD:291342
		FXa_inhibition	241..278	CDD:291342
		vWFA	<319..358	CDD:294047
		FXa_inhibition	366..402	CDD:291342
		vWFA	<460..502	CDD:294047
		FXa_inhibition	509..544	CDD:291342
		FXa_inhibition	550..585	CDD:291342
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910