Protein Alignment Cyp28a5 and ERG11

DIOPT Version :9

• Sequence 1: NP_609694.1
• Gene: Cyp28a5 / 34817
• FlyBaseID: FBgn0028940
• Length: 505
• Species: Drosophila melanogaster
• Sequence 2: NP_011871.1
• Gene: ERG11 / 856398
• SGDID: S000001049
• Length: 530
• Species: Saccharomyces cerevisiae
• Alignment Length: 524
• Identity: 110/524 - (20%)
• Similarity: 194/524 - (37%)
• Gaps: 140/524 - (26%)

  Fly     1 MVLITLTLVSLVVGLLYAV------LVWNYDYWRKRGVPGPKPKLLCGNYPNMFTMKRHAIYDLD 59
            :::|...:.::|..|||::      ||:   ||    :|.....::.|..|..|
Yeast    33 LIIIIPFIYNIVWQLLYSLRKDRPPLVF---YW----IPWVGSAVVYGMKPYEF----------- 79

  Fly    60 DIYRQYKNKYDAVGIFGSRSPQLLVINPALARRV-----------FVSNFKNFHDNEIAKNIDEK 113
              :.:.:.||..:..|            .|..||           ||.|         ||..|..
Yeast    80 --FEECQKKYGDIFSF------------VLLGRVMTVYLGPKGHEFVFN---------AKLADVS 121

  Fly   114 TDFIFANNPFSLTGE---------KWKTRRADVTPGLTMGRIKTVYPVTNKVCQKLTEWVEKQLR 169
            .:..:|:....:.|:         :...::..|...||....|:..|:       :.|.|.|..|
Yeast   122 AEAAYAHLTTPVFGKGVIYDCPNSRLMEQKKFVKGALTKEAFKSYVPL-------IAEEVYKYFR 179

  Fly   170 LGSKDGIDAKHMSLCFTTEMVTDCVLG-------------LGAESFSDKPTPIMSKINDLFN--Q 219
                   |:|:..|...|....|.::.             ||.|..:...|......:||..  .
Yeast   180 -------DSKNFRLNERTTGTIDVMVTQPEMTIFTASRSLLGKEMRAKLDTDFAYLYSDLDKGFT 237

  Fly   220 PWTFVLFFILTSSFPS--LSHLIKLRFVPVDVERFFVDLMGSAVETRRAQLAAGKQFERSDFLDY 282
            |..||        ||:  |.|..|.......:...::.|    ::.||    .....:..|.:|.
Yeast   238 PINFV--------FPNLPLEHYRKRDHAQKAISGTYMSL----IKERR----KNNDIQDRDLIDS 286

  Fly   283 ILQLGEKRN---LDNRQLLAYSMTFLLDGFETTATVLAHILLNLGRNKEAQNLLREEIRSHLQDG 344
            :::....::   :.::::....:..|:.|..|:|...|.|||:|....:.|..|.||....|..|
Yeast   287 LMKNSTYKDGVKMTDQEIANLLIGVLMGGQHTSAATSAWILLHLAERPDVQQELYEEQMRVLDGG 351

  Fly   345 --TIAFEKLSDLPYLDACVQETIRLFPPGFMSNKLCTESIEIPNKEGPNFVVEKGTTVVV-PHYC 406
              .:.::.|.::|.|:..::||:|:..|.....:...:.:.:||   .::|:..|..|:| |.|.
Yeast   352 KKELTYDLLQEMPLLNQTIKETLRMHHPLHSLFRKVMKDMHVPN---TSYVIPAGYHVLVSPGYT 413

  Fly   407 FMLDEEFFPNPQSFQPERFLEPDAAKTFR------------ERGV---FMGFGDGPRVCIGMRFA 456
            .:.| |:|||...|...|: ..|:|.::.            .:||   ::.||.|...|||..||
Yeast   414 HLRD-EYFPNAHQFNIHRW-NKDSASSYSVGEEVDYGFGAISKGVSSPYLPFGGGRHRCIGEHFA 476

  Fly   457 TVQI 460
            ..|:
Yeast   477 YCQL 480

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp28a5	NP_609694.1	p450	33..500	CDD:299894	101/486 (21%)
ERG11	NP_011871.1	CYP51-like	83..521	CDD:410668	97/454 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	103	1.000	Domainoid score	I1492
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	97	1.000	Inparanoid score	I1477
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.960