Protein Alignment Cyp28a5 and TBXAS1

DIOPT Version :9

• Sequence 1: NP_609694.1
• Gene: Cyp28a5 / 34817
• FlyBaseID: FBgn0028940
• Length: 505
• Species: Drosophila melanogaster
• Sequence 2: NP_001159725.2
• Gene: TBXAS1 / 6916
• HGNCID: 11609
• Length: 579
• Species: Homo sapiens
• Alignment Length: 595
• Identity: 124/595 - (20%)
• Similarity: 229/595 - (38%)
• Gaps: 131/595 - (22%)

  Fly     6 LTLVSLVVGLLYAVLVW----NYDYWRKRGVPGPKPKLLCGNYPNMFTMKRHAIYDLDDIYRQYK 66
            :..|:|.|.|| |:|.|    .:....|.|:..|||....||    .|..|...::..   .:.:
Human    15 MVTVALSVALL-ALLKWYSTSAFSRLEKLGLRHPKPSPFIGN----LTFFRQGFWESQ---MELR 71

  Fly    67 NKYDAV-GIFGSRSPQLLVINPALARRVFVSNFKNFHDNEIAKNIDEKTDFIFANNPFSLTGEKW 130
            ..|..: |.:..|...:::..|.:.::|.|.||.|| .|.:|..::.|:   .|::...|..::|
Human    72 KLYGPLCGYYLGRRMFIVISEPDMIKQVLVENFSNF-TNRMASGLEFKS---VADSVLFLRDKRW 132

  Fly   131 KTRRADV---------------------------------TPGLTMGRIKTVY------------ 150
            :..|..:                                 .|...:.:...:|
Human   133 EEVRGALMSAFSPEKLNELGLLIMQERIKGHMGGQQAPQRIPPTRLSKPSGIYVNLHYATLPFCM 197

  Fly   151 -PVTNKVCQKLTEWVEKQLRLGSKDGIDAKHMSLCFTTEMVTDCVLGLGAESFSDKPTPIMSKIN 214
             |:.::.|..|...:::....|  |..|.:.....:||::|.....|...:|:.....|.:....
Human   198 VPLISQACDLLLAHLKRYAESG--DAFDIQRCYCNYTTDVVASVAFGTPVDSWQAPEDPFVKHCK 260

  Fly   215 DLFNQPWTFVL---FFILTSSFPSLSHLIKL-RFVP----VDVERFFVDLMGSAVETRRAQLAAG 271
            ..|.    |.:   ..:|..||||:  ::.| |.:|    .::..||..|:.:.:..|..|.|
Human   261 RFFE----FCIPRPILVLLLSFPSI--MVPLARILPNKNRDELNGFFNKLIRNVIALRDQQAA-- 317

  Fly   272 KQFERSDFLDYILQ-------LGEK----------------------------RNLDNRQLLAYS 301
             :..|.|||..:|.       :|.:                            |.|...:::..:
Human   318 -EERRRDFLQMVLDARHSASPMGVQDFDIVRDVFSSTGCKPNPSRQHQPSPMARPLTVDEIVGQA 381

  Fly   302 MTFLLDGFETTATVLAHILLNLGRNKEAQNLLREEI----RSHLQDGTIAFEKLSDLPYLDACVQ 362
            ..||:.|:|.....|:.....|..|.:.|..|..|:    ..|:.....:.|:  .|||||..:.
Human   382 FIFLIAGYEIITNTLSFATYLLATNPDCQEKLLREVDVFKEKHMAPEFCSLEE--GLPYLDMVIA 444

  Fly   363 ETIRLFPPGFMSNKLCTESIEIPNKEGPNFVVEKGTTVVVPHYCFMLDEEFFPNPQSFQPERFLE 427
            ||:|::||.|...:...:..|:..:..|...|.:.....:.|     |.|.:|:|::|.||||..
Human   445 ETLRMYPPAFRFTREAAQDCEVLGQRIPAGAVLEMAVGALHH-----DPEHWPSPETFNPERFTA 504

  Fly   428 PDAAKTFRERGVFMGFGDGPRVCIGMRFATVQIKAAIVELISKFNVKINDKTRKDNDYEPGQIIT 492
              .|:.......::.||.|||.|:|:|...:::|..::.::.||..:...:|:.....|....:
Human   505 --EARQQHRPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFRFQACPETQVPLQLESKSAL- 566

  Fly   493 GLRGGIWLDL 502
            |.:.|:::.:
Human   567 GPKNGVYIKI 576

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp28a5	NP_609694.1	p450	33..500	CDD:299894	114/560 (20%)
TBXAS1	NP_001159725.2	p450	47..576	CDD:306555	114/560 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.920