DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp28a5 and CYP3A43

DIOPT Version :9

Sequence 1:	NP_609694.1	Gene:	Cyp28a5 / 34817	FlyBaseID:	FBgn0028940	Length:	505	Species:	Drosophila melanogaster
Sequence 2:	NP_073731.1	Gene:	CYP3A43 / 64816	HGNCID:	17450	Length:	504	Species:	Homo sapiens

Alignment Length:	528	Identity:	138/528 - (26%)
Similarity:	244/528 - (46%)	Gaps:	72/528 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 TLTLVSLVVGLLYAVLVWNYDYWRKRGVPGPKPKLLCGNYPNMFTMKRHAIYDLDDIYRQYKNKY 69
            |..||:..:.|||.....::..::|.|:|||.|....|..  :|.::  .:::.|   |:...||
Human    11 TWVLVATSLVLLYIYGTHSHKLFKKLGIPGPTPLPFLGTI--LFYLR--GLWNFD---RECNEKY 68

  Fly    70 DAV-GIFGSRSPQLLVINPALARRVFVSNFKNFHDNEIAKNIDE--KTDFIFANNPFSLTGEKWK 131
            ..: |::..:.|.|::::|.:.:.|.|....:...|::......  |:...||.:      |:||
Human    69 GEMWGLYEGQQPMLVIMDPDMIKTVLVKECYSVFTNQMPLGPMGFLKSALSFAED------EEWK 127

  Fly   132 TRRADVTPGLTMGRIKTVYPVTNK----VCQKLTEWVEKQLRLGSKDGIDAKHMSLCFTTEMVTD 192
            ..|..::|..|..:.|.:.|:.::    :.:.|.:..|....:..||...|      :|.:::|.
Human   128 RIRTLLSPAFTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINLKDFFGA------YTMDVITG 186

  Fly   193 CVLGLGAESFSDKPTPIMSKINDL----FNQPWTFVLFFILTSSFPSLS---HLIKLRFVPVDVE 250
            .:.|:..:|.::...|.:..:..|    |..|     |.:|.|.||.|:   ..:.:...|.||.
Human   187 TLFGVNLDSLNNPQDPFLKNMKKLLKLDFLDP-----FLLLISLFPFLTPVFEALNIGLFPKDVT 246

  Fly   251 RFFVDLMGSAVETRRAQLAAGKQFERSDFLDYIL------QLGEKRNLDNRQLLAYSMTFLLDGF 309
            .|    :.:::|..:......||..|.||...::      :....:.|.:.:|:|.|:..:...:
Human   247 HF----LKNSIERMKESRLKDKQKHRVDFFQQMIDSQNSKETKSHKALSDLELVAQSIIIIFAAY 307

  Fly   310 ETTATVLAHILLNLGRNKEAQNLLREEIRSHLQD-GTIAFEKLSDLPYLDACVQETIRLFPPGFM 373
            :||:|.|..|:..|..:.:.|..|:|||.:.|.: ..:.::.|..:.|||..|.||:||||....
Human   308 DTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNKAPVTYDALVQMEYLDMVVNETLRLFPVVSR 372

  Fly   374 SNKLCTESIEIPNKEGPNFV-VEKGTTVVVPHYCFMLDEEFFPNPQSFQPE-RFLE--PDAAKTF 434
            ..::|.:.|||      |.| :.||..|:||.|....|.:::..|:.|.|| ||.:  .|:...:
Human   373 VTRVCKKDIEI------NGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPESRFSKKNKDSIDLY 431

  Fly   435 RERGVFMGFGDGPRVCIGMRFATVQIKAAIVELISKFNVKINDKT----RKDN-----DYEPGQI 490
            |    ::.||.|||.|||||||...||.|::..:..|:.|...:|    :.||     ..:|..:
Human   432 R----YIPFGAGPRNCIGMRFALTNIKLAVIRALQNFSFKPCKETQIPLKLDNLPILQPEKPIVL 492

  Fly   491 ITGLRGGI 498
            ...||.||
Human   493 KVHLRDGI 500

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp28a5	NP_609694.1	p450	33..500	CDD:299894	130/500 (26%)
CYP3A43	NP_073731.1	p450	39..494	CDD:278495	126/492 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.820