DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp28a5 and Cyp3a25

DIOPT Version :9

Sequence 1:	NP_609694.1	Gene:	Cyp28a5 / 34817	FlyBaseID:	FBgn0028940	Length:	505	Species:	Drosophila melanogaster
Sequence 2:	NP_062766.2	Gene:	Cyp3a25 / 56388	MGIID:	1930638	Length:	503	Species:	Mus musculus

Alignment Length:	503	Identity:	127/503 - (25%)
Similarity:	236/503 - (46%)	Gaps:	72/503 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LTLVSLVVGLLYAVLVWNYDYWRKRGVPGPKPKLLCGNYPNMFTMKRHAIYDLD-DIYRQYKNKY 69
            |.:.|||:..:|.  .:::..::|.|:|||||..|.|...|.:    ..::..| |.|::|...:
Mouse    14 LLVTSLVLFYIYG--TYSHGLFKKLGIPGPKPLPLLGTIFNYY----DGMWKFDEDCYKKYGKIW 72

  Fly    70 DAVGIFGSRSPQLLVINPALARRVFVSNFKNFHDNEIAKNIDEKTDFIFANNPF---------SL 125
               |.:....|.|.:::|.:.:.|.|....:                :|.|..|         ::
Mouse    73 ---GFYEGPQPILAIMDPEIIKIVLVKECYS----------------VFTNRRFFGPVGFMKKAI 118

  Fly   126 T---GEKWKTRRADVTPGLTMGRIKTVYPVTNKVCQKLTEWVEKQLRLGSKDGIDAKHMSLCFTT 187
            |   .|:||..|..::|..|.|::|.::|:..:....|...:.::...|  :.|..|.:...::.
Mouse   119 TISEDEEWKRLRTLLSPTFTSGKLKEMFPIMRQYGDILVRNLRREEEKG--EPISMKDIFGAYSM 181

  Fly   188 EMVTDCVLGLGAESFSDKPTPIMSKINDLFN----QPWTFVLFFILTSSFPSLS---HLIKLRFV 245
            :::|....|:..:|.::...|.:.|...:..    .|  |:|..||   ||.|:   .::.....
Mouse   182 DVITGTSFGVNVDSLNNPQDPFVQKAKKILKFKIFDP--FLLSIIL---FPFLTPIYEMLNFSIF 241

  Fly   246 PVDVERFFVDLMGSAVETRRAQLAAGKQFERSDFLDYILQLGEKRN------LDNRQLLAYSMTF 304
            |.|...||...    |:..:.:..|..|..|.|||..::.....:.      |.:.::.|.::.|
Mouse   242 PRDSMNFFKKF----VKRMKKERLASNQKNRVDFLQLMMNTQNSKGQESQKALSDLEMAAQAVIF 302

  Fly   305 LLDGFETTATVLAHILLNLGRNKEAQNLLREEI-RSHLQDGTIAFEKLSDLPYLDACVQETIRLF 368
            :..|::.|:|.::.|:..|..:.:.|..|::|| |:......:.::.|.|:.|||..|.|::||:
Mouse   303 IFGGYDATSTSISLIMYELATHPDVQKKLQDEIDRTLPNKAPVTYDALMDMEYLDMVVNESLRLY 367

  Fly   369 PPGFMSNKLCTESIEIPNKEGPNFV-VEKGTTVVVPHYCFMLDEEFFPNPQSFQPERFLEPDAAK 432
            |......::..:.:||      |.| :.|||.|::|.|....:.|::|.||.|.||||.:.:...
Mouse   368 PIAIRLERVSKKDVEI------NGVFIPKGTVVMIPIYPLHRNPEYWPEPQEFCPERFSKENKGN 426

  Fly   433 TFRERGVFMGFGDGPRVCIGMRFATVQIKAAIVELISKFNVKINDKTR 480
            .  :..::|.||:|||.|||||||.:.||.|::.::..|.|:..::|:
Mouse   427 I--DPYIYMPFGNGPRNCIGMRFALISIKLAVIGVLQNFTVQPCEETQ 472

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp28a5	NP_609694.1	p450	33..500	CDD:299894	120/476 (25%)
Cyp3a25	NP_062766.2	p450	39..493	CDD:278495	120/476 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.820