DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp28a5 and cyp3c4

DIOPT Version :9

Sequence 1:	NP_609694.1	Gene:	Cyp28a5 / 34817	FlyBaseID:	FBgn0028940	Length:	505	Species:	Drosophila melanogaster
Sequence 2:	NP_001071016.1	Gene:	cyp3c4 / 558541	ZFINID:	ZDB-GENE-060929-96	Length:	507	Species:	Danio rerio

Alignment Length:	508	Identity:	135/508 - (26%)
Similarity:	242/508 - (47%)	Gaps:	68/508 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 ITLTLVSLVVGLLYAVLVWNYDYWRKRGVPGPKPKLLCGNYPNMFTMKRHAIYDLDDIYRQYKNK 68
            :|.|||.||:.||:...||.:.::.|.|:|||:|      :|.:.|:..:| ..|.:...:...|
Zfish     9 VTWTLVVLVITLLFIYGVWPHRFFIKLGIPGPRP------WPFVGTLLSYA-KGLCNFDMECAKK 66

  Fly    69 YDAV-GIFGSRSPQLLVINPALARRVFVSN-FKNFHDNEIAKNIDEKTDFIFANNPFS-----LT 126
            |..| ||:..|.|.|:|.:..:.:.|.|.. :.||        |:.:........|||     :.
Zfish    67 YGKVWGIYDGRLPILMVADLEVIKVVLVKECYSNF--------INRRKRTTGLAGPFSDGIIMVK 123

  Fly   127 GEKWKTRRADVTPGLTMGRIKTVYPVTNKVCQKLTEWVEKQLRLGSKDGIDAKHMSLCFTTEMVT 191
            .|:||..|:.::|..|.||:|.::|:......:..:.::|:   ..:..:..|.:...::.:::|
Zfish   124 DERWKRMRSTLSPYFTSGRLKEIFPIAMTHADRFIKNMQKK---DPEQPVKIKEVVAPYSLDVIT 185

  Fly   192 DCVLGLGAESFSDKPTPIMSKIN-----DLFNQPWTFVLFFILTSSFPSLSHLIKLRFVPV---D 248
            .....:..:|.::...|.:..:.     ::||.    :|..||.  ||||:..:|...|.:   .
Zfish   186 SSSFSVDIDSINNPEDPFVINVKKFIQFNMFNP----LLLLILL--FPSLAIPLKKMGVTLFSKS 244

  Fly   249 VERFFVDLMGSAVETRRAQLAAGKQFE-RSDFLDYILQ------------LGEK--RNLDNRQLL 298
            ...||..::      ::.:....|:.| |.|||..:||            ..|:  :.|.:.::|
Zfish   245 AMDFFYSVL------KKIKDDHNKESEGRVDFLKLMLQNQIPDDQIQDSDTSEQPAKGLTDHEIL 303

  Fly   299 AYSMTFLLDGFETTATVLAHILLNLGRNKEAQNLLREEIRSHLQ-DGTIAFEKLSDLPYLDACVQ 362
            :.|:.|:|.|:|||:|.|..:|.||..|.:....|.|||..:.. |..|.::.|..:.||:..:.
Zfish   304 SQSLVFILGGYETTSTTLTFLLYNLATNPDCLEKLVEEIDKNFPLDTPITYDALMRMDYLEMAIN 368

  Fly   363 ETIRLFPPGFMSNKLCTESIEIPNKEGPNFVVEKGTTVVVPHYCFMLDEEFFPNPQSFQPERFLE 427
            |::||.|......:...:::.|     ....:.:||.|.:|.|....|.:.:.:|..|:|||| .
Zfish   369 ESMRLLPTAPRLERSAKKTVVI-----NGLTIPEGTLVGIPTYVLSHDPDIWESPGEFRPERF-S 427

  Fly   428 PDAAKTFRERGVFMGFGDGPRVCIGMRFATVQIKAAIVELISKFNVKINDKTR 480
            |:....|.:. .|:.||.|||.|||||:|.:.:|..:|:|:..|:|:...:|:
Zfish   428 PENKSEFLQY-AFIPFGLGPRNCIGMRYAVMIMKLFVVKLLQNFSVETCKETQ 479

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp28a5	NP_609694.1	p450	33..500	CDD:299894	123/479 (26%)
cyp3c4	NP_001071016.1	p450	38..485	CDD:278495	123/479 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.820