DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp28a5 and cyp3c2

DIOPT Version :9

Sequence 1:	NP_609694.1	Gene:	Cyp28a5 / 34817	FlyBaseID:	FBgn0028940	Length:	505	Species:	Drosophila melanogaster
Sequence 2:	XP_021330384.1	Gene:	cyp3c2 / 558473	ZFINID:	ZDB-GENE-081103-62	Length:	503	Species:	Danio rerio

Alignment Length:	506	Identity:	133/506 - (26%)
Similarity:	240/506 - (47%)	Gaps:	52/506 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 ITLTLVSLVVGLLYAVLVWNYDYWRKRGVPGPKPKLLCGNYPNMFTMKRHAIYDLDDIYRQYKNK 68
            :|..||.||:.|||...||.:.:::|.|:|||:|....|.    |.......::.|   .:...|
Zfish     9 VTWILVVLVLTLLYMYGVWPHGFFKKLGIPGPRPWPFFGT----FLSYTKGFFNFD---MECAKK 66

  Fly    69 YDAV-GIFGSRSPQLLVINPALARRVFVSNFKNFHDNEIAKNIDEKTDFIFANNPFSLTGEKWKT 132
            |..| ||:..|.|.|:|.:..:.:.:.|....:...|....|:|....  .|:...::..|:||.
Zfish    67 YGKVWGIYDGRLPILMVTDLEMIKTIMVKECYSTFTNRREINVDLAGP--LADGITAVKDERWKR 129

  Fly   133 RRADVTPGLTMGRIKTVYPVTNKVCQKLTEWVEKQLRLGS-KDGIDAKHMSLCFTTEMVTDCVLG 196
            .|..::|..|.||:|.::|:......:..    |.::.|. :..:..|.:...::.::||.....
Zfish   130 IRGTLSPYFTSGRLKEIFPIAMTHADRFI----KNMQKGDHEQPVKIKEVMASYSLDVVTSSAFS 190

  Fly   197 LGAESFSDKPTPIMSKINDL--FNQPWTFVLFFILTSSFPSLSHLI-KL---RFVPVDVERFFVD 255
            :..:|.::...|.::.|.:.  ||   .|.||.:|.:.|||:::|: |:   .|....|:.|:..
Zfish   191 VDIDSINNPDDPFVTNIKNFLKFN---LFGLFVLLLTVFPSIANLLGKMGLSMFSKPTVDFFYKA 252

  Fly   256 LMGSAVETRRAQLAAGKQFERSDFLDYILQ-----------LGE--KRNLDNRQLLAYSMTFLLD 307
            |.....|.:.:.       .|.||...::|           ..|  ::.|.:.::|:.|..|::.
Zfish   253 LRKIKEEHKDSN-------GRVDFFRLMIQNEIPDDQVKDTTSEQPEKGLTDHEILSQSFIFIMG 310

  Fly   308 GFETTATVLAHILLNLGRNKEAQNLLREEIRSHLQ-DGTIAFEKLSDLPYLDACVQETIRLFPPG 371
            |:|||:|.|..:|.||..|.:....|.|:|..:.. |..|:::.|..:.||:..:.|::||.|..
Zfish   311 GYETTSTTLTFLLYNLAINPDCLEKLVEKIDKNFPLDTPISYDALMKIDYLEMSINESMRLLPTA 375

  Fly   372 FMSNKLCTESIEIPNKEGPNFVVEKGTTVVVPHYCFMLDEEFFPNPQSFQPERFLEPDAAKTFRE 436
            ....::|.:::|:     ....:.|.|.:.:|.|....|.:.:.:|..|:|||| .|:....|.:
Zfish   376 PRLERVCKKTVEM-----NGITIPKDTMITIPTYVLNQDPQLWDSPHEFRPERF-SPENKSEFLQ 434

  Fly   437 RGVFMGFGDGPRVCIGMRFATVQIKAAIVELISKFNVKINDKTRKDNDYEP 487
            . .||.||.|||.|||||:|.:.:|..:|:|:..|:|:...:|:...:..|
Zfish   435 Y-AFMPFGLGPRNCIGMRYALMIVKLLVVKLLQNFSVETCKETQIPLELNP 484

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp28a5	NP_609694.1	p450	33..500	CDD:299894	121/477 (25%)
cyp3c2	XP_021330384.1	p450	38..496	CDD:306555	121/477 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910