DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp28a5 and Cyp6a22

DIOPT Version :9

Sequence 1:	NP_609694.1	Gene:	Cyp28a5 / 34817	FlyBaseID:	FBgn0028940	Length:	505	Species:	Drosophila melanogaster
Sequence 2:	NP_001286431.1	Gene:	Cyp6a22 / 49847	FlyBaseID:	FBgn0013773	Length:	499	Species:	Drosophila melanogaster

Alignment Length:	527	Identity:	138/527 - (26%)
Similarity:	248/527 - (47%)	Gaps:	60/527 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LITLTLVSLVVGLLYAVLVW----NYDYWRKRGVPGPKPKLLCGNYPNMFTMKRHAIYDLDDIYR 63
            ::.|.|::|.||.      |    .|.||.:||:.....:...||... |...:|.|..:..||.
  Fly     4 VVALLLIALAVGF------WFVRTRYSYWTRRGIGSEPARFPVGNMEG-FRKNKHFIDIVTPIYE 61

  Fly    64 QYK-NKYDAVGIFGSRSPQLLVINPALARRVFVSNFKNFHDNEIAKNIDEKTDFIFANNPFSLTG 127
            ::| |.....|.|....|.:||.:..||:::.:.:|.||.|..:..|  |:.|.: ..:.|.:.|
  Fly    62 KFKGNGAPFAGFFMMLRPVVLVTDLELAKQILIQDFANFEDRGMYHN--ERDDPL-TGHLFRIDG 123

  Fly   128 EKWKTRRADVTPGLTMGRIKTVYPVTNKVCQKLTEWVEKQLRLGSKDGI-DAKHMSLCFTTEMVT 191
            .||:..|..::|..|..::|.::|...:|.::||: |..:|...:..|| :...:...:|::::.
  Fly   124 PKWRPLRQKMSPTFTSAKMKYMFPTVCEVGEELTQ-VCGELADNAMCGILEIGDLMARYTSDVIG 187

  Fly   192 DCVLG---------------LGAESFSDKPTPIMSKINDLFNQPWTFVLFFILTSSFPSLSHLIK 241
            .|..|               :|..:||::.   ..|:.|.|            ..|||.::..::
  Fly   188 RCAFGVECNGLRNPEAEFAIMGRRAFSERR---HCKLVDGF------------IESFPEVARFLR 237

  Fly   242 LRFVPVDVERFFVDLMGSAVETRRAQLAAGKQFERSDFLDYILQLGEKRNLDNRQLLAYSMTFLL 306
            :|.:..|:..|:|.::...|:.|..|     ...||||::.::::.::..|...::.|.:..|..
  Fly   238 MRQIHQDITDFYVGIVRETVKQREEQ-----GIVRSDFMNLLIEMKQRGELTIEEMAAQAFIFFA 297

  Fly   307 DGFETTATVLAHILLNLGRNKEAQNLLREEIRS--HLQDGTIAFEKLSDLPYLDACVQETIRLFP 369
            .||:|:|:.|...|..|.:....|..|||||..  .|.:|...::.:.:|.|::..:.||:|.:|
  Fly   298 AGFDTSASTLGFALYELAKQPALQAKLREEIDQALRLHNGEFTYDSMQELRYMELVIAETLRKYP 362

  Fly   370 PGFMSNKLCTESIEIPNKEGP-NFVVEKGTTVVVPHYCFMLDEEFFPNPQSFQPERFLEPDAAKT 433
               :..:|...|..:...:|. :|.:|.|..:::|.|....|...:|.|..|.|||||....|:
  Fly   363 ---ILPQLTRISRHLYAAKGDRHFYIEPGQMLLIPVYGIHHDPALYPEPHKFIPERFLADQLAQ- 423

  Fly   434 FRERGVFMGFGDGPRVCIGMRFATVQIKAAIVELISKFNVKINDKTRKDNDYEPGQIITGLRGGI 498
             |....::.||||||.||||||..:|....:|.|:..|:..:..:|....::....|:.....||
  Fly   424 -RPTAAWLPFGDGPRNCIGMRFGKMQTTIGLVSLLRNFHFSVCPRTDPKIEFLKSNILLCPANGI 487

  Fly   499 WLDLEKL 505
            :|.:::|
  Fly   488 YLKVQQL 494

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp28a5	NP_609694.1	p450	33..500	CDD:299894	125/486 (26%)
Cyp6a22	NP_001286431.1	p450	35..491	CDD:278495	126/485 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45460975
Domainoid	1	1.000	151	1.000	Domainoid score	I1386
eggNOG	1	0.900	-	-		E2759_KOG0158
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	161	1.000	Inparanoid score	I1621
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm3438
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
	9	8.900