Protein Alignment Cyp28a5 and CYP4F3

DIOPT Version :10

• Sequence 1: NP_609694.1
• Gene: Cyp28a5 / 34817
• FlyBaseID: FBgn0028940
• Length: 505
• Species: Drosophila melanogaster
• Sequence 2: NP_000887.2
• Gene: CYP4F3 / 4051
• HGNCID: 2646
• Length: 520
• Species: Homo sapiens
• Alignment Length: 547
• Identity: 132/547 - (24%)
• Similarity: 242/547 - (44%)
• Gaps: 96/547 - (17%)

  Fly     8 LVSLVVG---LLYAVLVWNYDYW----RKRGVP-GPKPKLLCGNYPNMFTMKRHAIY------DL 58
            |:.|:||   ||..:|.|.|.::    |.|..| .||.....|:...:.:.:...:|      ..
Human    20 LLLLLVGASWLLARILAWTYTFYDNCCRLRCFPQPPKRNWFLGHLGLIHSSEEGLLYTQSLACTF 84

  Fly    59 DDIYRQYKNKYDA-VGIFGSRSPQLLVINPAL---ARRVFVSNFKNFHDNEIAKNIDEKTDFIFA 119
            .|:...:...:.| |.||.....:.::..||.   ..:||.|..|.:..:.:..:
Human    85 GDMCCWWVGPWHAIVRIFHPTYIKPVLFAPAAIVPKDKVFYSFLKPWLGDGLLLS---------- 139

  Fly   120 NNPFSLTGEKWKTRRADVTPGLTMGRIKTVYPVTNKVCQKL-TEWVEKQLRLGSKDG---IDA-K 179
                  .||||...|..:||......:|....:.|:....: .:|     :|.:.:|   :|. :
Human   140 ------AGEKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKW-----QLLASEGSARLDMFE 193

  Fly   180 HMSLCFTTEMVTDCVLGLGAESFSDKPTPIMSKINDLFNQPWTFVLFFILTSSFPS-LSHLIKLR 243
            |:|| .|.:.:..||....:.. .:||:..::.|.:         |..::|..... |.::..|.
Human   194 HISL-MTLDSLQKCVFSFDSHC-QEKPSEYIAAILE---------LSALVTKRHQQILLYIDFLY 247

  Fly   244 FVPVDVERF------FVDLMGSAVETRRAQ---------LAAGKQFERSDFLDYILQLGEK--RN 291
            ::..|.:||      ..|...:.::.||..         |.|..:.:..||:|.:|...::  :.
Human   248 YLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKK 312

  Fly   292 LDNRQLLAYSMTFLLDGFETTATVLAHILLNLGRNKEAQNLLREEIRSHLQD---GTIAFEKLSD 353
            |.:..:.|.:.||:.:|.:|||:.|:.:|.:|.::.|.|...|:|::..|:|   ..|.::.|:.
Human   313 LSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAQ 377

  Fly   354 LPYLDACVQETIRLFPPGFMSNKLCTESIEIPNKEGPNFVVEKGTTVVVPHYCFMLDEEFFPNPQ 418
            ||:|..|::|::||.||....::.||:.|.:|:..    |:.||...::..:....:...:|:|:
Human   378 LPFLTMCIKESLRLHPPVPAVSRCCTQDIVLPDGR----VIPKGIICLISVFGTHHNPAVWPDPE 438

  Fly   419 SFQPERFLEPDAAKTFRERG--VFMGFGDGPRVCIGMRFATVQIKAAIVELISKFNVKINDKTRK 481
            .:.|.|| :|   |..:||.  .|:.|..|||.|||..||..::|..:...:.:|.| :.|.|
Human   439 VYDPFRF-DP---KNIKERSPLAFIPFSAGPRNCIGQAFAMAEMKVVLGLTLLRFRV-LPDHT-- 496

  Fly   482 DNDYEP---GQIITGLRGGIWLDLEKL 505
                ||   .:::....||:||.:|.|
Human   497 ----EPRRKPELVLRAEGGLWLRVEPL 519

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp28a5	NP_609694.1	CYP6-like	67..499	CDD:410679	111/466 (24%)
CYP4F3	NP_000887.2	CYP4F	74..515	CDD:410772	114/487 (23%)