DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp28a5 and Cyp6a14

DIOPT Version :9

Sequence 1:	NP_609694.1	Gene:	Cyp28a5 / 34817	FlyBaseID:	FBgn0028940	Length:	505	Species:	Drosophila melanogaster
Sequence 2:	NP_001286199.1	Gene:	Cyp6a14 / 35835	FlyBaseID:	FBgn0033302	Length:	509	Species:	Drosophila melanogaster

Alignment Length:	530	Identity:	144/530 - (27%)
Similarity:	269/530 - (50%)	Gaps:	47/530 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 VLITLTLVSLVVGLLYAVLVWNYDYWRKRGVPGPKPKLLCGNYPNMFTMKRHAIYDLDD-IYRQY 65
            :|.|:.||.:|:||.|::.:..:.||:::|||...|..:.||...:  :|::...|::. ||:::
  Fly     1 MLFTIALVGVVLGLAYSLHIKIFSYWKRKGVPHETPLPIVGNMRGI--VKKYHFRDINQRIYKKF 63

  Fly    66 KNKYDAVGIFGSRSPQLLVINPALARRVFVSNFKNFHDNEIAKN--IDEKTDFIFANNPFSLTGE 128
            |.:....|::.......|:.:....::|.:.:|..|.|.....|  .|..|..:||     |.||
  Fly    64 KGQGPIAGMYMFFKRTALITDLDFIKQVMIKDFSYFQDRGAFTNPRDDPLTGHLFA-----LEGE 123

  Fly   129 KWKTRRADVTPGLTMGRIKTVYPVTNKVCQKLTEWVEKQLRLG--SKDGIDAKHMSLCFTTEMVT 191
            :|:..|..:||..|.|:||.:..|...|..:|.:.::|.::..  .:..::.|.:...|||:::.
  Fly   124 EWRAMRHKLTPVFTSGKIKQMSKVIVDVGLRLGDAMDKAVKEAKVEEGNVEIKDLCARFTTDVIG 188

  Fly   192 DCVLGLGAESFSDKPTPIMSKINDLF--NQPWTFVLFFILTSSFPSLSHLIKLRFVPVDVERFFV 254
            .|..||...|..|.......|..::|  .:..|.|..||.|::  .|:..::::.:|.|:.:||:
  Fly   189 SCAFGLECNSLQDPSAEFRQKGREIFTRRRHSTLVQSFIFTNA--RLARKLRIKVLPDDLTQFFM 251

  Fly   255 DLMGSAVETRRAQLAAGKQFERSDFLDYILQL----------GEKRNLDN----RQLLAYSMTFL 305
            ..:.:.|:.|   |..|  .:|:||::.:::|          |:..:|.:    .|:.|.:..|.
  Fly   252 STVKNTVDYR---LKNG--IKRNDFIEQMIELRAEDQEAAKKGQGIDLSHGLTLEQMAAQAFVFF 311

  Fly   306 LDGFETTATVLAHILLNLGRNKEAQNLLREEIRS---HLQDGTIAFEKLSDLPYLDACVQETIRL 367
            :.||||:::.::..|..|....:.|..|||||.|   ::..|.:.::.|:.:.|||..:.||:|.
  Fly   312 VAGFETSSSTMSLCLYELALQPDIQQRLREEIESVLANVDGGELNYDVLAQMTYLDQVLSETLRK 376

  Fly   368 FP--PGFMSNKLCTESIEIPNKEGPNFVVEKGTTVVVPHYCFMLDEEFFPNPQSFQPERFLEPDA 430
            .|  |..:  :..|:..:|||.:   .|::||...::|.:....|.|.:|.|:.|.|.|| :|:.
  Fly   377 HPLLPHLI--RETTKDYQIPNSD---IVLDKGILALIPVHNIHHDPEIYPEPEKFDPSRF-DPEE 435

  Fly   431 AKTFRERGVFMGFGDGPRVCIGMRFATVQIKAAIVELISKFNVKINDKTRKDNDYEPGQIITGLR 495
            .|. |....::.||||||.|||:||..:|.|..:|.|:.:|...::::|.....:.....:....
  Fly   436 VKN-RHPMAYLPFGDGPRNCIGLRFGKIQAKIGLVSLLRRFKFSVSNRTDVPLIFSKKSFLLTTN 499

  Fly   496 GGIWLDLEKL 505
            .||:|.:|::
  Fly   500 DGIYLKVERV 509

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp28a5	NP_609694.1	p450	33..500	CDD:299894	130/492 (26%)
Cyp6a14	NP_001286199.1	p450	32..506	CDD:306555	131/494 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	151	1.000	Domainoid score	I1386
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	161	1.000	Inparanoid score	I1621
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm3438
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
	7	7.070