DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp28a5 and Cyp9b2

DIOPT Version :9

Sequence 1:	NP_609694.1	Gene:	Cyp28a5 / 34817	FlyBaseID:	FBgn0028940	Length:	505	Species:	Drosophila melanogaster
Sequence 2:	NP_523646.1	Gene:	Cyp9b2 / 35635	FlyBaseID:	FBgn0015039	Length:	505	Species:	Drosophila melanogaster

Alignment Length:	534	Identity:	124/534 - (23%)
Similarity:	235/534 - (44%)	Gaps:	65/534 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MVLITLTLVSLVVGLLYAVLVWN---YDYWRKRGVPGPKPKLLCGNYPNMFTMKRHAIYDLDDIY 62
            |.||.:.|..:|:|  |.:..|:   :..:.:|.:...||....||.......|......|.:.|
  Fly     1 MALIEICLALVVIG--YLIYKWSTATFKTFEERKLYFEKPYPFVGNMAAAALQKSSFQRQLTEFY 63

  Fly    63 ---RQYKNKYDAVGIFGSRSPQLLVINPALARRVFVSNFKNF--HDNEIAKNIDEKTDFIFANNP 122
               ||:|    .||.|..|:|.:.:.:|.|.::|.|.:|.:|  |...|..|     |.:|.:..
  Fly    64 ERTRQHK----LVGFFNMRTPMITLNDPELIKKVCVKDFDHFPNHQPFITSN-----DRLFNDML 119

  Fly   123 FSLTGEKWKTRRADVTPGLTMGRIKTVYPVTNKVCQKLTEWVEKQLR-LGSKDG--IDAKHMSLC 184
            ..:..::||..|..:||..|..:::.::.:.|:...:..:.::...: |..:.|  :|.|.|...
  Fly   120 SVMRDQRWKHMRNTLTPVFTAAKMRNMFTLMNESFAECLQHLDSSSKTLPGRKGFEVDMKVMCNK 184

  Fly   185 FTTEMVTDCVLGLGAESFSDKPTPIMSKIND--LFNQPWTFVLFFILTSSFPSLSHLIKLRFVPV 247
            .:.:::.....||...|: |.|.....:|..  :|::...| ..|:|::..|.|..|:||.....
  Fly   185 LSNDIIATTAFGLKVNSY-DNPKNEFYEIGQSLVFSRGLQF-FKFMLSTLVPKLFSLLKLTIFDS 247

  Fly   248 DVERFFVDLMGSAVETRRAQLAAGKQFERSDFLDYILQL---GEKRNLDNRQLLAYSMTFLLDGF 309
            ....:|..|:..|::.|...     ...|.|.:..:::.   .|.:..|: :::|....|....|
  Fly   248 AKVDYFARLVVEAMQYREKH-----NITRPDMIQLLMEAKNESEDKWTDD-EIVAQCFIFFFAAF 306

  Fly   310 ETTATVLAHILLNLGRNKEAQNLLREEI---RSHLQDGTIAFEKLSDLPYLDACVQETIRLFPPG 371
            |..:.::......|..|.:.|..|.|||   :..|....:.::.:..:.|:|..:.|::|.:...
  Fly   307 ENNSNLICTTTYELLYNPDVQERLYEEIVETKKALNGAPLTYDAVQKMTYMDMVISESLRKWTLA 371

  Fly   372 FMSNKLCTESIEIPNKEGPN-FVVEKGTTVVVPHYCFMLDEEFFPNPQSFQPERFLEPDAAKTFR 435
            ..:::||::...:.:.:|.. |..:.|..:.:|.....||:.:||.|:.|.|:||.|       .
  Fly   372 AATDRLCSKDYTLTDDDGTKLFDFKVGDRINIPISGLHLDDRYFPEPRKFDPDRFSE-------E 429

  Fly   436 ERG-----VFMGFGDGPRVCIGMRFATVQIKAAIVELISKFNVKINDKTRKD-------NDYEPG 488
            .:|     .::.||.|||.|||.|:|.:|:|..:..|:..:.::.:.:|.||       .::.|
  Fly   430 RKGDMVPYTYLPFGVGPRNCIGNRYALMQVKGMLFNLLLHYKIEASPRTIKDLWGSASGFNFTP- 493

  Fly   489 QIITGLRGGIWLDL 502
                  |.|.|:.|
  Fly   494 ------RSGFWMHL 501

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp28a5	NP_609694.1	p450	33..500	CDD:299894	113/495 (23%)
Cyp9b2	NP_523646.1	p450	37..478	CDD:299894	107/464 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45460905
Domainoid	1	1.000	151	1.000	Domainoid score	I1386
eggNOG	1	0.900	-	-		E2759_KOG0158
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	161	1.000	Inparanoid score	I1621
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm3438
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
	9	8.900