DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp28a5 and cyp3c1

DIOPT Version :9

Sequence 1:	NP_609694.1	Gene:	Cyp28a5 / 34817	FlyBaseID:	FBgn0028940	Length:	505	Species:	Drosophila melanogaster
Sequence 2:	NP_997838.1	Gene:	cyp3c1 / 324340	ZFINID:	ZDB-GENE-030131-3060	Length:	505	Species:	Danio rerio

Alignment Length:	503	Identity:	141/503 - (28%)
Similarity:	244/503 - (48%)	Gaps:	60/503 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 ITLTLVSLVVGLLYAVLVWNYDYWRKRGVPGPKPKLLCGNYPNMFTMKRHAIYDLDDIYRQYKNK 68
            :|.|||.||:.||....||.:.:::|.|:|||:|....|.  .:...|....:|:     :...|
Zfish     9 VTWTLVVLVITLLLIYGVWPHGFFKKLGIPGPRPLPFVGT--ALSYSKGICNFDI-----ECSKK 66

  Fly    69 YDAV-GIFGSRSPQLLVINPALARRVFV----SNFKNFHDNEIAKNIDEKTDFIFANNPFSLTGE 128
            |..| ||:..|.|.|||.:..:.:.:.|    |.|.|      .:|::......||:....:..|
Zfish    67 YGKVWGIYDGRLPLLLVTDLEMIKTILVKDCYSTFTN------RRNMNPDLVGPFADGITLVKDE 125

  Fly   129 KWKTRRADVTPGLTMGRIKTVYPVTNKVCQKLTEWVEKQ---LRLGSKDGIDAKHMSLCFTTEMV 190
            :|:..|:.::|..|.||:|.::|:......:..:.:||:   |.|..||.:..      ::.::|
Zfish   126 RWRRIRSSLSPYFTSGRLKEIFPIAMTHADRFIKNMEKKDPNLPLKIKDVVAP------YSLDVV 184

  Fly   191 TDCVLGLGAESFSDKPTPIMSKINDLFN----QPWTFVLFFILTSSFPSLSHLIKLRFVPVDVER 251
            ......:..:|.::...|.::.|...||    .|     .|:|.:..||.::|:....:.| ..|
Zfish   185 ASSSFSVDFDSINNPDDPFVTSIKSFFNINPLSP-----LFLLLAFCPSAANLLAKMGISV-FSR 243

  Fly   252 FFVDLMGSAVETRRAQLAAGKQFERSDFLDYILQ-----------LGEK--RNLDNRQLLAYSMT 303
            ...|....|:  |:.:....:...|.|||..::|           ..|:  :.|.:.::|:.|..
Zfish   244 STTDFYYKAL--RKIKDEHNESNGRVDFLKLMIQNQIPDDQVKDTASEQPVKGLTDHEILSQSFI 306

  Fly   304 FLLDGFETTATVLAHILLNLGRNKEAQNLLREEIRSHLQ-DGTIAFEKLSDLPYLDACVQETIRL 367
            |:|.|:|||:|.|:::|.||..|.:....|.|||..:.. |..|.::.|..:.||:..:.|::|:
Zfish   307 FILGGYETTSTTLSYLLYNLATNPDCLEKLVEEIDKNFPLDIPITYDALMRMDYLEMAIHESMRV 371

  Fly   368 FPPGFMSNKLCTESIEIPNKEGPNFVVEKGTTVVVPHYCFMLDEEFFPNPQSFQPERFLEPDAAK 432
            ||.|....::|.:::||     ....:.|.|.|.:|.|....|.:.:.:|..|:|||| .|: :|
Zfish   372 FPAGPRLERVCKKTVEI-----NGITIPKNTLVGIPLYVLSRDPDLWESPNEFKPERF-SPE-SK 429

  Fly   433 TFRERGVFMGFGDGPRVCIGMRFATVQIKAAIVELISKFNVKINDKTR 480
            |...:..||.||.|||.|||||||.:.:|..:|:|:.|:.|:...:|:
Zfish   430 TEINQCAFMPFGLGPRNCIGMRFALMMMKLLVVKLLQKYTVETCKETQ 477

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp28a5	NP_609694.1	p450	33..500	CDD:299894	129/474 (27%)
cyp3c1	NP_997838.1	p450	38..496	CDD:278495	129/474 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.910