Protein Alignment Cyp28a5 and CYP4V2

DIOPT Version :10

• Sequence 1: NP_609694.1
• Gene: Cyp28a5 / 34817
• FlyBaseID: FBgn0028940
• Length: 505
• Species: Drosophila melanogaster
• Sequence 2: NP_997235.3
• Gene: CYP4V2 / 285440
• HGNCID: 23198
• Length: 525
• Species: Homo sapiens
• Alignment Length: 543
• Identity: 135/543 - (24%)
• Similarity: 240/543 - (44%)
• Gaps: 87/543 - (16%)

  Fly     4 ITLTLVSLVVGLLYAVLVWNYDYWRKRGVPGPKPKLLCGNYPNMFTMKRHAIY---DLDDIYRQ- 64
            ::|...|||:.||..|..:...:.:.|.:|     .:...||    :..||:.   |..:.::|
Human    22 LSLAGASLVLSLLQRVASYARKWQQMRPIP-----TVARAYP----LVGHALLMKPDGREFFQQI 77

  Fly    65 --YKNKYDAVGIFGSRSPQLLVINPALARRVFVSNFKNFHDNEI----AKNIDEKTDFIFANNPF 123
              |..:|        |...||.:.......|.:.|.:|.   |:    :|.||:.:.:.|.....
Human    78 IEYTEEY--------RHMPLLKLWVGPVPMVALYNAENV---EVILTSSKQIDKSSMYKFLEPWL 131

  Fly   124 SL-----TGEKWKTRRADVTPGLTMGRIKTVYPVTNKVCQKLTEWVEKQLRLGSKDGIDA-KHMS 182
            .|     ||.||::||..:||......::....:.|:....|.:.:||.:   :::..:. .:::
Human   132 GLGLLTSTGNKWRSRRKMLTPTFHFTILEDFLDIMNEQANILVKKLEKHI---NQEAFNCFFYIT 193

  Fly   183 LCFTTEMVTDCVLG--LGAESFSD----KPTPIMSKINDLFNQ---PWTFV-LFFILTSSFPSLS 237
            || ..:::.:..:|  :||:|..|    :....||::  :|.:   ||.:: |::::...  ...
Human   194 LC-ALDIICETAMGKNIGAQSNDDSEYVRAVYRMSEM--IFRRIKMPWLWLDLWYLMFKE--GWE 253

  Fly   238 HLIKLRFVPVDVERFFVDLMGSAVETRRAQL------------AAGKQFERSDFLDYILQL--GE 288
            |...|:.:..        ...|.:..|..::            :|..:.:|..|||.:|.:  .|
Human   254 HKKSLQILHT--------FTNSVIAERANEMNANEDCRGDGRGSAPSKNKRRAFLDLLLSVTDDE 310

  Fly   289 KRNLDNRQLLAYSMTFLLDGFETTATVLAHILLNLGRNKEAQNLLREEIRSHL--QDGTIAFEKL 351
            ...|.:..:.....||:.:|.:|||..:...|..||.|.|.|..:..|:....  .|.....|.|
Human   311 GNRLSHEDIREEVDTFMFEGHDTTAAAINWSLYLLGSNPEVQKKVDHELDDVFGKSDRPATVEDL 375

  Fly   352 SDLPYLDACVQETIRLFPPGFMSNKLCTESIEIPNKEGPNFVVEKGTTVVVPHYCFMLDEEFFPN 416
            ..|.||:..::||:||||...:..:..:|..|:     ..:.|.|||..|:..|....|..:|||
Human   376 KKLRYLECVIKETLRLFPSVPLFARSVSEDCEV-----AGYRVLKGTEAVIIPYALHRDPRYFPN 435

  Fly   417 PQSFQPERFLEPDAAKTFRERGVFMGFGDGPRVCIGMRFATVQIKAAIVELISKFNVKINDKTRK 481
            |:.||||||. |:.|:. |....::.|..|||.|||.:||.::.|..:..::..|.::.|.| |:
Human   436 PEEFQPERFF-PENAQG-RHPYAYVPFSAGPRNCIGQKFAVMEEKTILSCILRHFWIESNQK-RE 497

  Fly   482 DNDYEPGQIITGLRGGIWLDLEK 504
            :...| ||:|.....|||:.|::
Human   498 ELGLE-GQLILRPSNGIWIKLKR 519

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp28a5	NP_609694.1	CYP6-like	67..499	CDD:410679	116/467 (25%)
CYP4V2	NP_997235.3	CYP4V	76..515	CDD:410773	119/474 (25%)