DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp28a5 and Cyp3a2

DIOPT Version :9

Sequence 1:	NP_609694.1	Gene:	Cyp28a5 / 34817	FlyBaseID:	FBgn0028940	Length:	505	Species:	Drosophila melanogaster
Sequence 2:	NP_695224.3	Gene:	Cyp3a2 / 266682	RGDID:	708379	Length:	504	Species:	Rattus norvegicus

Alignment Length:	501	Identity:	130/501 - (25%)
Similarity:	239/501 - (47%)	Gaps:	71/501 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MVLITLTLVSLVVGLLYAVLVWNYDYWRKRGVPGPKPKLLCGNYPNMFTMKRHAIYDLDDIYRQY 65
            :.|.|..|:::::.|||.:....:..::|:|:|||||....|...|.:  |....:|: :.|::|
  Rat     7 LTLETWVLLAVILVLLYRLGTHRHGIFKKQGIPGPKPLPFLGTVLNYY--KGLGRFDM-ECYKKY 68

  Fly    66 KNKYDAVGIFGSRSPQLLVINPALARRVFVSNFKNFHDNEIAKNIDEKTDF-IFAN----NPFSL 125
            ...:   |:|..::|...::                 |.|:.||:..|..| :|.|    .|..:
  Rat    69 GKIW---GLFDGQTPVFAIM-----------------DTEMIKNVLVKECFSVFTNRRDFGPVGI 113

  Fly   126 TG--------EKWKTRRADVTPGLTMGRIKTVYPVTNKVCQKLTEWVEKQLRLGSKDGIDAKHMS 182
            .|        |:||..||.::|..|.||:|.::|:..:....|.::::::...|..  :..|.:.
  Rat   114 MGKAVSVAKDEEWKRYRALLSPTFTSGRLKEMFPIIEQYGDILVKYLKQEAETGKP--VTMKKVF 176

  Fly   183 LCFTTEMVTDCVLGLGAESFSDKPTPIMSKINDLFNQPWTFVLFFILTSSFPSLS---HLIKLRF 244
            ..::.:::|....|:..:|.::...|.:.|...|....: |...|:....||.|:   .::.:..
  Rat   177 GAYSMDVITSTSFGVNVDSLNNPKDPFVEKTKKLLRFDF-FDPLFLSVVLFPFLTPIYEMLNICM 240

  Fly   245 VPVDVERFFVDLMGSAVETRRAQLAAGKQFERSDFLDYILQLGEK-------RNLDNRQLLAYSM 302
            .|.|...||...:....|||    ...|...|.|||..:|.....       :.|.:.:::|.|:
  Rat   241 FPKDSIAFFQKFVHRIKETR----LDSKHKHRVDFLQLMLNAHNNSKDEVSHKALSDVEIIAQSV 301

  Fly   303 TFLLDGFETTATVLAHILLNLGRNKEAQNLLREEIRSHLQDGTI------AFEKLSDLPYLDACV 361
            .|:..|:|||::.|:.:|..|..:.:.|..|:|||     ||.:      .::.:.::.|||..:
  Rat   302 IFIFAGYETTSSTLSFVLYFLATHPDIQKKLQEEI-----DGALPSKAPPTYDIVMEMEYLDMVL 361

  Fly   362 QETIRLFPPGFMSNKLCTESIEIPNKEGPNFVVEKGTTVVVPHYCFMLDEEFFPNPQSFQPERFL 426
            .||:||:|.|....::|.:.||:     ....:.||:.|.:|.|....|.:.:|.|:.|.||||.
  Rat   362 NETLRLYPIGNRLERVCKKDIEL-----DGLFIPKGSVVTIPTYALHHDPQHWPKPEEFHPERFS 421

  Fly   427 EPDAAKTFRERGVFMGFGDGPRVCIGMRFATVQIKAAIVELISKFN 472
            :.:  |...:..|::.||:|||.|||||||.:.:|.|:.:::..|:
  Rat   422 KEN--KGSIDPYVYLPFGNGPRNCIGMRFALMNMKLALTKVLQNFS 465

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp28a5	NP_609694.1	p450	33..500	CDD:299894	122/469 (26%)
Cyp3a2	NP_695224.3	CYP3A	67..493	CDD:410743	112/438 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.920