Protein Alignment Cyp28a5 and Cyp3a23-3a1

DIOPT Version :10

• Sequence 1: NP_609694.1
• Gene: Cyp28a5 / 34817
• FlyBaseID: FBgn0028940
• Length: 505
• Species: Drosophila melanogaster
• Sequence 2: NP_037237.2
• Gene: Cyp3a23-3a1 / 25642
• RGDID: 628626
• Length: 502
• Species: Rattus norvegicus
• Alignment Length: 535
• Identity: 137/535 - (25%)
• Similarity: 247/535 - (46%)
• Gaps: 82/535 - (15%)

  Fly     1 MVLITLTLVSLVVGLLYAVLVWNYDYWRKRGVPGPKPKLLCGNYPNMFTMKRHAIYDLD-DIYRQ 64
            :.|.|..|:::|:.|||......:..::|:|:|||||....|...|.:.    .::..| :.:::
  Rat     7 LTLETWVLLAVVLVLLYGFGTRTHGLFKKQGIPGPKPLPFFGTVLNYYM----GLWKFDVECHKK 67

  Fly    65 YKNKYDAVGIFGSRSPQLLVINPALARRVFVSNFKNFHDNEIAKNIDEKTDF-IFAN----NPFS 124
            |...:   |:|..:.|...:.                 |.|:.||:..|..| :|.|    .|..
  Rat    68 YGKIW---GLFDGQMPLFAIT-----------------DTEMIKNVLVKECFSVFTNRRDFGPVG 112

  Fly   125 LTG--------EKWKTRRADVTPGLTMGRIKTVYPVTNKVCQKLTEWVEKQLRLGSKDGIDAKHM 181
            :.|        |:||..||.::|..|.||:|.::|    |.::..:.:.|.||......:..|.:
  Rat   113 IMGKAISVSKDEEWKRYRALLSPTFTSGRLKEMFP----VIEQYGDILVKYLRQEKGKPVPVKEV 173

  Fly   182 SLCFTTEMVTDCVLGLGAESFSDKPTPIMSKINDLFNQPWTFVLFFILTSSFPSLS---HLIKLR 243
            ...::.:::|....|:..:|.::...|.:.|...|....: |...|:....||.|:   .::.:.
  Rat   174 FGAYSMDVITSTSFGVNVDSLNNPKDPFVEKAKKLLRIDF-FDPLFLSVVLFPFLTPVYEMLNIC 237

  Fly   244 FVPVDVERFFVDLMGSAVETRRAQLAAGKQFERSDFLDYILQL----GEKRN---LDNRQLLAYS 301
            ..|.|...||...:....|||...:    |..|.|||..::..    .:|.:   |.:.::.|.|
  Rat   238 MFPKDSIEFFKKFVYRMKETRLDSV----QKHRVDFLQLMMNAHNDSKDKESHTALSDMEITAQS 298

  Fly   302 MTFLLDGFETTATVLAHILLNLGRNKEAQNLLREEI-RSHLQDGTIAFEKLSDLPYLDACVQETI 365
            :.|:..|:|.|::.|:.:|.:|..:.:.|..|:||| |:........::.:.::.|||..:.||:
  Rat   299 IIFIFAGYEPTSSTLSFVLHSLATHPDTQKKLQEEIDRALPNKAPPTYDTVMEMEYLDMVLNETL 363

  Fly   366 RLFPPGFMSNKLCTESIEIPNKEGPNFVVEKGTTVVVPHYCFMLDEEFFPNPQSFQPERFLEPDA 430
            ||:|.|....::|.:.:||.....|     ||:.|::|.|....|.:.:|.|:.|:||||.:.:
  Rat   364 RLYPIGNRLERVCKKDVEINGVFMP-----KGSVVMIPSYALHRDPQHWPEPEEFRPERFSKEN- 422

  Fly   431 AKTFRERGVFMGFGDGPRVCIGMRFATVQIKAAIVELISKFN------VKINDKTRKDNDYEP-- 487
             |...:..|::.||:|||.|||||||.:.:|.|:.:::..|:      .:|..|..:....:|
  Rat   423 -KGSIDPYVYLPFGNGPRNCIGMRFALMNMKLALTKVLQNFSFQPCKETQIPLKLSRQGLLQPTK 486

  Fly   488 ---------GQIITG 493
                     .:||||
  Rat   487 PIILKVVPRDEIITG 501

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp28a5	NP_609694.1	CYP6-like	67..499	CDD:410679	119/468 (25%)
Cyp3a23-3a1	NP_037237.2	CYP3A	67..491	CDD:410743	116/459 (25%)