DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp28a5 and erg5

DIOPT Version :9

Sequence 1:	NP_609694.1	Gene:	Cyp28a5 / 34817	FlyBaseID:	FBgn0028940	Length:	505	Species:	Drosophila melanogaster
Sequence 2:	NP_593788.2	Gene:	erg5 / 2542469	PomBaseID:	SPAC19A8.04	Length:	543	Species:	Schizosaccharomyces pombe

Alignment Length:	528	Identity:	113/528 - (21%)
Similarity:	207/528 - (39%)	Gaps:	102/528 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 TLTLVSLVVGLLYAVLVWNYDYWRKRG-VPGPKPKL-LCGNYPNMFTMKRHAIYDLDDIYRQYKN 67
            |:....|.|.:.|..:    .|..::| :|||:.|: ..|::  :.:||        ..:.:|..
pombe    30 TICFALLAVCIAYDQI----SYQMQKGHIPGPRFKIPFMGSF--LDSMK--------PTFEKYNA 80

  Fly    68 KY-----DAVGIFGSRSPQLLVI--NPALARRVFVSNFKNFHDN---EIAKNIDEKTDFIFANNP 122
            |:     ..|.:|    .:.:||  ...|||::.  |..::...   :..|.|.:.|:::|
pombe    81 KWQTGPLSCVSVF----HKFVVIASERDLARKIL--NSPSYVQPCVVDAGKKILKHTNWVF---- 135

  Fly   123 FSLTGEKWKTRRADVTPGLTMGRIKTVYPVTNKVCQKLTEWVEKQLRLGSKDGIDAKHMSLCFTT 187
              |.|......|..:....|...:.:..|....|..|..    |:....|||.. |::|......
pombe   136 --LDGRDHIEYRKGLNGLFTTRALASYLPAQEAVYNKYF----KEFLAHSKDDY-AQYMIPFRDI 193

  Fly   188 EMVTDCVLGLGAESFSD----------KPTPIMSKINDLFNQPWTFVLFFILTSSFPSLSHLIKL 242
            .:.|.|....|.....|          |.|..|..:|            |.:...|..:.:.|:.
pombe   194 NVATSCRTFCGYYISDDAIKHIADEYWKITAAMELVN------------FPIVLPFTKVWYGIQS 246

  Fly   243 RFVPVDVERFFVDLMGSAVETRRAQLAAG------------KQFERSDFLDYILQLGEK-----R 290
            |.|   |.|:|   |.:|.|:|: .:.||            :..|...:.....:..||     |
pombe   247 RKV---VMRYF---MKAAAESRK-NMEAGNAPACMMEEWIHEMIETRKYKSENKEGAEKPSVLIR 304

  Fly   291 NLDNRQLLAYSMTFLLDGFETTATVLAHILLNLGRNKEAQNLLREE---IRSHLQDGTIAFEKLS 352
            ...:.::....::||....:.|::.:..:...|..:.:....:|||   ||....|..::.:.:.
pombe   305 EFSDEEISLTFLSFLFASQDATSSAMTWLFQLLADHPDVLQKVREEQLRIRKGDIDVPLSLDLME 369

  Fly   353 DLPYLDACVQETIRLFPPGFMSNKLCTESIEIPNKEGPNFVVEKGTTVVVPHYCFMLDEEFFPNP 417
            .:.|..|.|:|.:||.||..|......::..|.    |::.|.|...|:...|..:.|.:.:|.|
pombe   370 KMTYTRAVVKECLRLRPPVLMVPYRVKKAFPIT----PDYTVPKDAMVIPTLYGALHDSKVYPEP 430

  Fly   418 QSFQPERFLEPDAAKTFRERGVFMGFGDGPRVCIGMRFATVQIKAAIVELISKFNVKINDKTRKD 482
            ::|.|:|:.....|:...:.  :|.||:||.||:|.|:|...    ::..|.|.::.::.|.::.
pombe   431 ETFNPDRWAPNGLAEQSPKN--WMVFGNGPHVCLGQRYAVNH----LIACIGKASIMLDWKHKRT 489

  Fly   483 NDYEPGQI 490
            .|.:...|
pombe   490 PDSDTQMI 497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp28a5	NP_609694.1	p450	33..500	CDD:299894	107/499 (21%)
erg5	NP_593788.2	CypX	57..505	CDD:225035	105/497 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	88	1.000	Domainoid score	I2119
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	88	1.000	Inparanoid score	I1773
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
TreeFam	0	0.000	Not matched by this tool.
	3	3.050