Protein Alignment Cyp28a5 and CYP51A1

DIOPT Version :10

• Sequence 1: NP_609694.1
• Gene: Cyp28a5 / 34817
• FlyBaseID: FBgn0028940
• Length: 505
• Species: Drosophila melanogaster
• Sequence 2: NP_000777.1
• Gene: CYP51A1 / 1595
• HGNCID: 2649
• Length: 509
• Species: Homo sapiens
• Alignment Length: 510
• Identity: 114/510 - (22%)
• Similarity: 192/510 - (37%)
• Gaps: 127/510 - (24%)

  Fly     1 MVLI----TLTLVSLV---VGLLYAVLVWNYDYWRKRGVPGPKPKLLCGNYPNMFT---MKRHA- 54
            |:||    ||:||.|:   .|.|..:         ..||..|         |.:|:   ...||
Human    35 MLLIACAFTLSLVYLIRLAAGHLVQL---------PAGVKSP---------PYIFSPIPFLGHAI 81

  Fly    55 ------IYDLDDIYRQYKN--KYDAVG-----IFGSRSPQLLVINPALARRVFVSNFKNFHDNEI 106
                  |..|::.|.:|..  .:..||     :.||.:..||          |.|..::.:..::
Human    82 AFGKSPIEFLENAYEKYGPVFSFTMVGKTFTYLLGSDAAALL----------FNSKNEDLNAEDV 136

  Fly   107 AKNIDEKTDFIFAN-------NPFSLTGEKWKTRRADVTPGLTMGRIKTVYPVTNKVCQKLTE-W 163
            ...:   |..:|..       ||..|..:|.      :..||.:...|....:..|..::..| |
Human   137 YSRL---TTPVFGKGVAYDVPNPVFLEQKKM------LKSGLNIAHFKQHVSIIEKETKEYFESW 192

  Fly   164 VEKQLRLGSKDGIDAKHMSLCFTTEMVTDCVLGLGAESFSDKPTPIMSKINDLFNQPWTFVLFFI 228
            .|.    |.|:..:|....:..|   .:.|:.|          ..|.|::|:...|     |:..
Human   193 GES----GEKNVFEALSELIILT---ASHCLHG----------KEIRSQLNEKVAQ-----LYAD 235

  Fly   229 LTSSFPSLSHLIKLRFVPVD-------VERFFVDLMGSAVETRRAQLAAGKQFERSDFLDYILQL 286
            |...|...:.|:. .::|:.       ..|...|:...|::.||.     .|.:..|.|..:|..
Human   236 LDGGFSHAAWLLP-GWLPLPSFRRRDRAHREIKDIFYKAIQKRRQ-----SQEKIDDILQTLLDA 294

  Fly   287 GEK--RNLDNRQLLAYSMTFLLDGFETTATVLAHILLNLGRNKEAQNLLREEIRSHLQDGTI--- 346
            ..|  |.|.:.::....:..||.|..|::|..|.:...|.|:|..|.      :.:|:..|:
Human   295 TYKDGRPLTDDEVAGMLIGLLLAGQHTSSTTSAWMGFFLARDKTLQK------KCYLEQKTVCGE 353

  Fly   347 -----AFEKLSDLPYLDACVQETIRLFPPGFMSNKLCTESIEIPNKEGPNFVVEKGTTVVVPHYC 406
                 .:::|.||..||.|::||:||.||..:..::......:     ..:.:..|..|.|....
Human   354 NLPPLTYDQLKDLNLLDRCIKETLRLRPPIMIMMRMARTPQTV-----AGYTIPPGHQVCVSPTV 413

  Fly   407 FMLDEEFFPNPQSFQPERFLEPDAAKTFRERGVFMGFGDGPRVCIGMRFATVQIK 461
            ....::.:.....|.|:|:|:.:.|.  .|:..::.||.|...|||..||.||||
Human   414 NQRLKDSWVERLDFNPDRYLQDNPAS--GEKFAYVPFGAGRHRCIGENFAYVQIK 466

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp28a5	NP_609694.1	CYP6-like	67..499	CDD:410679	93/427 (22%)
CYP51A1	NP_000777.1	CYP51-like	94..505	CDD:410668	95/433 (22%)