Protein Alignment Cyp28a5 and CYP3A5

DIOPT Version :10

• Sequence 1: NP_609694.1
• Gene: Cyp28a5 / 34817
• FlyBaseID: FBgn0028940
• Length: 505
• Species: Drosophila melanogaster
• Sequence 2: NP_000768.1
• Gene: CYP3A5 / 1577
• HGNCID: 2638
• Length: 502
• Species: Homo sapiens
• Alignment Length: 489
• Identity: 127/489 - (25%)
• Similarity: 230/489 - (47%)
• Gaps: 57/489 - (11%)

  Fly     6 LTLVSLVVGLLYAVLVWNYDYWRKRGVPGPKPKLLCGNYPNMFTMKRHAIYDLD-DIYRQYKNKY 69
            |..||||  |||......:..:::.|:|||.|..|.||..:.    |..::..| :.|::|...:
Human    14 LLAVSLV--LLYLYGTRTHGLFKRLGIPGPTPLPLLGNVLSY----RQGLWKFDTECYKKYGKMW 72

  Fly    70 DAVGIFGSRSPQLLVINPALARRVFVSNFKNFHDNEIAKNIDEKTDFIFANNPFSLT-GEKWKTR 133
               |.:..:.|.|.:.:|.:.|.|.|....:...|..:..     ...|..:..||. .|:||..
Human    73 ---GTYEGQLPVLAITDPDVIRTVLVKECYSVFTNRRSLG-----PVGFMKSAISLAEDEEWKRI 129

  Fly   134 RADVTPGLTMGRIKTVYPVTNKVCQKLTEWVEKQLRLGSKDGIDAKHMSLCFTTEMVTDCVLGLG 198
            |:.::|..|.|::|.::|:..:....|...:.::...|..  :..|.:...::.:::|....|:.
Human   130 RSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKP--VTLKDIFGAYSMDVITGTSFGVN 192

  Fly   199 AESFSDKPTPIMSK---------INDLFNQPWTFVLFFILTSSFPSLSHLIKLRFVPVDVERFFV 254
            .:|.::...|.:..         ::.||   .:.:||..||..|.:|:    :...|.|.    :
Human   193 IDSLNNPQDPFVESTKKFLKFGFLDPLF---LSIILFPFLTPVFEALN----VSLFPKDT----I 246

  Fly   255 DLMGSAVETRRAQLAAGKQFERSDFLDYIL------QLGEKRNLDNRQLLAYSMTFLLDGFETTA 313
            :.:..:|...:......||..|.|||..::      :....:.|.:.:|.|.|:.|:..|:|||:
Human   247 NFLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYETTS 311

  Fly   314 TVLAHILLNLGRNKEAQNLLREEIRSHLQD-GTIAFEKLSDLPYLDACVQETIRLFPPGFMSNKL 377
            :||:..|..|..:.:.|..|::||.:.|.: ....::.:..:.|||..|.||:||||......:.
Human   312 SVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFPVAIRLERT 376

  Fly   378 CTESIEIPNKEGPNFV-VEKGTTVVVPHYCFMLDEEFFPNPQSFQPERF-LEPDAAKTFRERGVF 440
            |.:.:||      |.| :.||:.||:|.|....|.:::..|:.|:|||| .:.|:...:    ::
Human   377 CKKDVEI------NGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSIDPY----IY 431

  Fly   441 MGFGDGPRVCIGMRFATVQIKAAIVELISKFNVK 474
            ..||.|||.|||||||.:.:|.|::.::..|:.|
Human   432 TPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFK 465

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp28a5	NP_609694.1	CYP6-like	67..499	CDD:410679	107/427 (25%)
CYP3A5	NP_000768.1	CYP3A	67..491	CDD:410743	108/430 (25%)