DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp28a5 and CYP3A5

DIOPT Version :9

Sequence 1:	NP_609694.1	Gene:	Cyp28a5 / 34817	FlyBaseID:	FBgn0028940	Length:	505	Species:	Drosophila melanogaster
Sequence 2:	NP_000768.1	Gene:	CYP3A5 / 1577	HGNCID:	2638	Length:	502	Species:	Homo sapiens

Alignment Length:	489	Identity:	127/489 - (25%)
Similarity:	230/489 - (47%)	Gaps:	57/489 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LTLVSLVVGLLYAVLVWNYDYWRKRGVPGPKPKLLCGNYPNMFTMKRHAIYDLD-DIYRQYKNKY 69
            |..||||  |||......:..:::.|:|||.|..|.||..:.    |..::..| :.|::|...:
Human    14 LLAVSLV--LLYLYGTRTHGLFKRLGIPGPTPLPLLGNVLSY----RQGLWKFDTECYKKYGKMW 72

  Fly    70 DAVGIFGSRSPQLLVINPALARRVFVSNFKNFHDNEIAKNIDEKTDFIFANNPFSLT-GEKWKTR 133
               |.:..:.|.|.:.:|.:.|.|.|....:...|..:..     ...|..:..||. .|:||..
Human    73 ---GTYEGQLPVLAITDPDVIRTVLVKECYSVFTNRRSLG-----PVGFMKSAISLAEDEEWKRI 129

  Fly   134 RADVTPGLTMGRIKTVYPVTNKVCQKLTEWVEKQLRLGSKDGIDAKHMSLCFTTEMVTDCVLGLG 198
            |:.::|..|.|::|.::|:..:....|...:.::...|..  :..|.:...::.:::|....|:.
Human   130 RSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKP--VTLKDIFGAYSMDVITGTSFGVN 192

  Fly   199 AESFSDKPTPIMSK---------INDLFNQPWTFVLFFILTSSFPSLSHLIKLRFVPVDVERFFV 254
            .:|.::...|.:..         ::.||   .:.:||..||..|.:|:    :...|.|.    :
Human   193 IDSLNNPQDPFVESTKKFLKFGFLDPLF---LSIILFPFLTPVFEALN----VSLFPKDT----I 246

  Fly   255 DLMGSAVETRRAQLAAGKQFERSDFLDYIL------QLGEKRNLDNRQLLAYSMTFLLDGFETTA 313
            :.:..:|...:......||..|.|||..::      :....:.|.:.:|.|.|:.|:..|:|||:
Human   247 NFLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYETTS 311

  Fly   314 TVLAHILLNLGRNKEAQNLLREEIRSHLQD-GTIAFEKLSDLPYLDACVQETIRLFPPGFMSNKL 377
            :||:..|..|..:.:.|..|::||.:.|.: ....::.:..:.|||..|.||:||||......:.
Human   312 SVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFPVAIRLERT 376

  Fly   378 CTESIEIPNKEGPNFV-VEKGTTVVVPHYCFMLDEEFFPNPQSFQPERF-LEPDAAKTFRERGVF 440
            |.:.:||      |.| :.||:.||:|.|....|.:::..|:.|:|||| .:.|:...:    ::
Human   377 CKKDVEI------NGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSIDPY----IY 431

  Fly   441 MGFGDGPRVCIGMRFATVQIKAAIVELISKFNVK 474
            ..||.|||.|||||||.:.:|.|::.::..|:.|
Human   432 TPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFK 465

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp28a5	NP_609694.1	p450	33..500	CDD:299894	118/462 (26%)
CYP3A5	NP_000768.1	p450	39..492	CDD:365848	118/462 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.820