DRSC/TRiP Functional Genomics Resources

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Protein Alignment Cyp28a5 and CYP3A4

DIOPT Version :10

Sequence 1:NP_609694.1 Gene:Cyp28a5 / 34817 FlyBaseID:FBgn0028940 Length:505 Species:Drosophila melanogaster
Sequence 2:NP_059488.2 Gene:CYP3A4 / 1576 HGNCID:2637 Length:503 Species:Homo sapiens


Alignment Length:502 Identity:128/502 - (25%)
Similarity:226/502 - (45%) Gaps:82/502 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly     6 LTLVSLVVGLLYAVLVWNYDYWRKRGVPGPKPKLLCGNYPN------MFTMKRHAIYDLDDIYRQ 64
            |..||||  |||.....::..::|.|:|||.|....||..:      ||.|:.|           
Human    14 LLAVSLV--LLYLYGTHSHGLFKKLGIPGPTPLPFLGNILSYHKGFCMFDMECH----------- 65

  Fly    65 YKNKYDAV-GIFGSRSPQLLVINPALARRVFVSNFKNFHDNEIAKNIDEKTDFIFAN-NPFSLTG 127
              .||..| |.:..:.|.|.:.:|.:.:.|.|....:                :|.| .||...|
Human    66 --KKYGKVWGFYDGQQPVLAITDPDMIKTVLVKECYS----------------VFTNRRPFGPVG 112

  Fly   128 -----------EKWKTRRADVTPGLTMGRIKTVYPVTNKVCQKLTEWVEKQLRLGSKDGIDAKHM 181
                       |:||..|:.::|..|.|::|.:.|:..:....|...:.::...|..  :..|.:
Human   113 FMKSAISIAEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKP--VTLKDV 175

  Fly   182 SLCFTTEMVTDCVLGLGAESFSDKPTPIMSKINDL----FNQPWTFVLFFILTSSFPSLSHLIKL 242
            ...::.:::|....|:..:|.::...|.:.....|    |..|     ||:..:.||.|..::::
Human   176 FGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDP-----FFLSITVFPFLIPILEV 235

  Fly   243 RFV---PVDVERFFVDLMGSAVETRRAQLAAGKQFERSDFLDYIL------QLGEKRNLDNRQLL 298
            ..:   |.:|..|    :..:|:..:.......|..|.|||..::      :....:.|.:.:|:
Human   236 LNICVFPREVTNF----LRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELV 296

  Fly   299 AYSMTFLLDGFETTATVLAHILLNLGRNKEAQNLLREEIRSHLQD-GTIAFEKLSDLPYLDACVQ 362
            |.|:.|:..|:|||::||:.|:..|..:.:.|..|:|||.:.|.: ....::.:..:.|||..|.
Human   297 AQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVN 361

  Fly   363 ETIRLFPPGFMSNKLCTESIEIPNKEGPNFVVEKGTTVVVPHYCFMLDEEFFPNPQSFQPERFLE 427
            ||:||||......::|.:.:||     ....:.||..|::|.|....|.:::..|:.|.||||.:
Human   362 ETLRLFPIAMRLERVCKKDVEI-----NGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSK 421

  Fly   428 PDAAKTFRERGVFMGFGDGPRVCIGMRFATVQIKAAIVELISKFNVK 474
            .:  |...:..::..||.|||.|||||||.:.:|.|::.::..|:.|
Human   422 KN--KDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFK 466

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Cyp28a5NP_609694.1 CYP6-like 67..499 CDD:410679 108/435 (25%)
CYP3A4NP_059488.2 CYP3A 67..492 CDD:410743 108/434 (25%)

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