DRSC/TRiP Functional Genomics Resources

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Protein Alignment Cyp28a5 and CYP3A4

DIOPT Version :9

Sequence 1:NP_609694.1 Gene:Cyp28a5 / 34817 FlyBaseID:FBgn0028940 Length:505 Species:Drosophila melanogaster
Sequence 2:NP_059488.2 Gene:CYP3A4 / 1576 HGNCID:2637 Length:503 Species:Homo sapiens


Alignment Length:502 Identity:128/502 - (25%)
Similarity:226/502 - (45%) Gaps:82/502 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly     6 LTLVSLVVGLLYAVLVWNYDYWRKRGVPGPKPKLLCGNYPN------MFTMKRHAIYDLDDIYRQ 64
            |..||||  |||.....::..::|.|:|||.|....||..:      ||.|:.|           
Human    14 LLAVSLV--LLYLYGTHSHGLFKKLGIPGPTPLPFLGNILSYHKGFCMFDMECH----------- 65

  Fly    65 YKNKYDAV-GIFGSRSPQLLVINPALARRVFVSNFKNFHDNEIAKNIDEKTDFIFAN-NPFSLTG 127
              .||..| |.:..:.|.|.:.:|.:.:.|.|....:                :|.| .||...|
Human    66 --KKYGKVWGFYDGQQPVLAITDPDMIKTVLVKECYS----------------VFTNRRPFGPVG 112

  Fly   128 -----------EKWKTRRADVTPGLTMGRIKTVYPVTNKVCQKLTEWVEKQLRLGSKDGIDAKHM 181
                       |:||..|:.::|..|.|::|.:.|:..:....|...:.::...|..  :..|.:
Human   113 FMKSAISIAEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKP--VTLKDV 175

  Fly   182 SLCFTTEMVTDCVLGLGAESFSDKPTPIMSKINDL----FNQPWTFVLFFILTSSFPSLSHLIKL 242
            ...::.:::|....|:..:|.::...|.:.....|    |..|     ||:..:.||.|..::::
Human   176 FGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDP-----FFLSITVFPFLIPILEV 235

  Fly   243 RFV---PVDVERFFVDLMGSAVETRRAQLAAGKQFERSDFLDYIL------QLGEKRNLDNRQLL 298
            ..:   |.:|..|    :..:|:..:.......|..|.|||..::      :....:.|.:.:|:
Human   236 LNICVFPREVTNF----LRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELV 296

  Fly   299 AYSMTFLLDGFETTATVLAHILLNLGRNKEAQNLLREEIRSHLQD-GTIAFEKLSDLPYLDACVQ 362
            |.|:.|:..|:|||::||:.|:..|..:.:.|..|:|||.:.|.: ....::.:..:.|||..|.
Human   297 AQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVN 361

  Fly   363 ETIRLFPPGFMSNKLCTESIEIPNKEGPNFVVEKGTTVVVPHYCFMLDEEFFPNPQSFQPERFLE 427
            ||:||||......::|.:.:||     ....:.||..|::|.|....|.:::..|:.|.||||.:
Human   362 ETLRLFPIAMRLERVCKKDVEI-----NGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSK 421

  Fly   428 PDAAKTFRERGVFMGFGDGPRVCIGMRFATVQIKAAIVELISKFNVK 474
            .:  |...:..::..||.|||.|||||||.:.:|.|::.::..|:.|
Human   422 KN--KDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFK 466

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Cyp28a5NP_609694.1 p450 33..500 CDD:299894 118/475 (25%)
CYP3A4NP_059488.2 p450 39..493 CDD:365848 118/475 (25%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D264519at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X40
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
43.920

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