DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp28a5 and tbxas1

DIOPT Version :9

Sequence 1:	NP_609694.1	Gene:	Cyp28a5 / 34817	FlyBaseID:	FBgn0028940	Length:	505	Species:	Drosophila melanogaster
Sequence 2:	XP_031753608.1	Gene:	tbxas1 / 100327243	XenbaseID:	XB-GENE-994325	Length:	532	Species:	Xenopus tropicalis

Alignment Length:	542	Identity:	134/542 - (24%)
Similarity:	228/542 - (42%)	Gaps:	112/542 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 ITLTLVSLVVGLLYAVLVWNYD---YWR--KRGVPGPKPKLLCGNYPNMFTMK------RHAIYD 57
            :|||||:..:||||    | |.   :|:  |.|:..|||....||.  |...|      ||.:
Frog    14 VTLTLVAGFLGLLY----W-YSVSAFWQLEKAGIKHPKPLPFIGNI--MLFQKGFWEGDRHLL-- 69

  Fly    58 LDDIYRQYKNKYDAVGIFGSRSPQLLVINPALARRVFVSNFKNFHDNEIAKNIDEKTDFIFANNP 122
                    |......|.:..|.|.:::..|...::|...:|.||.:.....|:..|.   .:::.
Frog    70 --------KTYGPICGYYMGRRPMIVIAEPDAIKQVLQKDFVNFTNRMQRLNLVTKP---MSDSL 123

  Fly   123 FSLTGEKWKTRRADVTPGLTMGRIKTVYPVTNKVCQKLTEWVEKQLRLGSKDGIDAKHMSLCFTT 187
            ..|..:|||..|:.:||..:..|:|.:.|:.|:.|..|.|.:.:....|  :..:.:....|||.
Frog   124 LCLRDDKWKRVRSVLTPSFSAARMKEMCPLINQCCDVLVENLMEYASSG--EACNVQRCYACFTM 186

  Fly   188 EMVTDCVLGLGAESFSDKPTPIM---SKINDLFNQPWTFVLFFILTSSFPSLSHLIKLRFVPV-- 247
            ::|.....|...:|..|...|::   .:..:||. |:..|:  :|..:|||:       .:|:
Frog   187 DVVASVAFGTQVDSQRDSDHPLVQNCKRFLELFT-PFKPVV--LLCLAFPSI-------MIPIAR 241

  Fly   248 --------DVERFFVDLMGSAVETRRAQLAAGKQFERSDFLDYILQLGE---------------- 288
                    .:..||:.::...:..|..|   .....|.|||..:|...:
Frog   242 RLPNKHRDRINSFFLKVIRDIIAFRENQ---PPNERRRDFLQLMLDARDSAGHVSVDHFDIVNQA 303

  Fly   289 -------------------KRNLDNRQLLAYSMTFLLDGFETTATVLAHILLNLGRNKEAQNLLR 334
                               ::.|:..::|..:..||:.|:|||.::|:.....|..:.:.|..|.
Frog   304 DLSVPQNQDRGQDPPRKSTQKTLNEEEILGQAFIFLIAGYETTCSLLSFASYLLATHPDCQEKLL 368

  Fly   335 EEIRSHLQDGTIA-FEKLSDLPYLDACVQETIRLFPPGFM----SNKLCT-ESIEIPNKEGPNFV 393
            :|:....|:...| :..:.||||::..:.||:|::||.:.    :.:.|| ..:.||
Frog   369 KEVDEFSQEHEEADYNTVHDLPYMEMVINETLRMYPPAYRFAREAARDCTVMGLGIP-------- 425

  Fly   394 VEKGTTVVVPHYCFMLDEEFFPNPQSFQPERFLEPDAAKTFRERGVFMGFGDGPRVCIGMRFATV 458
              .|..|.:|..|...|..|:..|:.|.||||...:..|  |...:|:.||.|||.|||||.|.:
Frog   426 --AGAVVEIPIGCLQNDPRFWHEPEKFNPERFTAEEKQK--RHPFLFLPFGAGPRSCIGMRLALL 486

  Fly   459 QIKAAIVELISKFNVKINDKTR 480
            :.|..:..::.||..:..|.|:
Frog   487 EAKITLYRVLRKFRFQTCDLTQ 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp28a5	NP_609694.1	p450	33..500	CDD:299894	120/508 (24%)
tbxas1	XP_031753608.1	cytochrome_P450	71..526	CDD:425388	110/468 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010