Protein Alignment NimC1 and MEGF11

DIOPT Version :10

• Sequence 1: NP_001260453.1
• Gene: NimC1 / 34816
• FlyBaseID: FBgn0259896
• Length: 622
• Species: Drosophila melanogaster
• Sequence 2: NP_001371957.1
• Gene: MEGF11 / 84465
• HGNCID: 29635
• Length: 1140
• Species: Homo sapiens
• Alignment Length: 808
• Identity: 200/808 - (24%)
• Similarity: 265/808 - (32%)
• Gaps: 296/808 - (36%)

  Fly    13 LSLSFGTSFAILRHGL-------NDCSHPESVPYNRKVLKSKLVPFQQYSYFH-----GWVTKYR 65
            |||:...:|:.|:..|       |.|||.||  |...|.:|...||.|..|..     .|....|
Human     3 LSLTGLIAFSFLQATLALNPEDPNVCSHWES--YAVTVQESYAHPFDQIYYTRCTDILNWFKCTR 65

  Fly    66 HQYVYEDETAYRTVM------RPSCCEGYEGSVENCKPVCRQQCPQHGFCSSPNTCSCNAGYGGI 124
            |:..|  :||||..:      |..||.||..|.:.|.|:|.::| .||.|.||:||.|..|:||.
Human    66 HRISY--KTAYRRGLRTMYRRRSQCCPGYYESGDFCIPLCTEEC-VHGRCVSPDTCHCEPGWGGP 127

  Fly   125 DCHPVCPT-----------VCGKNEFCDR-PGVCSCQNGYKRTSPSDNCLP-----VCEK--ECG 170
            ||...|.:           .|.....|:. .|.|.|..|::.....:.|.|     .|:.  :|.
Human   128 DCSSGCDSDHWGPHCSNRCQCQNGALCNPITGACVCAAGFRGWRCEELCAPGTHGKGCQLPCQCR 192

  Fly   171 HHSFCS-EPGKCECEPGYEKVGNGTVFPDGYKN---------NSNGNCSPI-------------- 211
            |.:.|. ..|:|.|.|||..|....:.|.|...         .:.|.|..|
Human   193 HGASCDPRAGECLCAPGYTGVYCEELCPPGSHGAHCELRCPCQNGGTCHHITGECACPPGWTGAV 257

  Fly   212 ----CP-----KDCGQNSRCVRPGVCE-------CENGYAGD---------DGGTNCRPVCSTCP 251
                ||     ::|.|:..|...|.|:       |..||.||         ..|..|...|. |.
Human   258 CAQPCPPGTFGQNCSQDCPCHHGGQCDHVTGQCHCTAGYMGDRCQEECPFGSFGFQCSQHCD-CH 321

  Fly   252 ENGLCLSP--GVCVCKPGY-----------------------------------VMRNDLCQP-- 277
            ..|.| ||  |.|.|:|||                                   |.....|||
Human   322 NGGQC-SPTTGACECEPGYKGPRCQERLCPEGLHGPGCTLPCPCDADNTISCHPVTGACTCQPGW 385

  Fly   278 ---HCEK----------------CSDNAHCVA-PNQCECFPGYESSGADKKCV-----PKCSK-- 315
               ||.:                |.:.|.|.: ...|.|.||:........|.     |.||.
Human   386 SGHHCNESCPVGYYGDGCQLPCTCQNGADCHSITGGCTCAPGFMGEVCAVSCAAGTYGPNCSSIC 450

  Fly   316 GCTNGFCFAP--ETCVCSIGYQ------------MGPNQVCEPKCSLNCVHGKCTSP--ETCTCD 364
            .|.||...:|  .:|.|..|:|            .|.|  |...|:  |.:|...||  .:|:|.
Human   451 SCNNGGTCSPVDGSCTCKEGWQGLDCTLPCPSGTWGLN--CNESCT--CANGAACSPIDGSCSCT 511

  Fly   365 PGY-------------------RFKDNSHHE-CDPI--------------CDSGCSNGHCVAPN- 394
            ||:                   ...|.||.: |||:              |||.|..|.. .||
Human   512 PGWLGDTCELPCPDGTFGLNCSEHCDCSHADGCDPVTGHCCCLAGWTGIRCDSTCPPGRW-GPNC 575

  Fly   395 --FCICHDGYQLNSTNPVTSMCQ-------PICKG-CQFG----DCVAP---------------N 430
              .|.|.:|   .|.:|....|:       |:|:. |..|    .|..|               .
Human   576 SVSCSCENG---GSCSPEDGSCECAPGFRGPLCQRICPPGFYGHGCAQPCPLCVHSSRPCHHISG 637

  Fly   431 VCECNVGYENINGLCELQTTTDSYEYSTTTVELQS-------STVDPQLQ---------TSTSEV 479
            :|||..|:.  ..||. |.....| :.....:|.|       |.:|...|         .|.:..
Human   638 ICECLPGFS--GALCN-QVCAGGY-FGQDCAQLCSCANNGTCSPIDGSCQCFPGWIGKDCSQACP 698

  Fly   480 P--------HS-NCTAGCMCWIEYDG--------MGTFNTAKCAKICVDPQDKPCLNLDNCQ--- 524
            |        |: :|..|..|..| ||        .|.|.|.:|.....   .|.|..:..||
Human   699 PGFWGPACFHACSCHNGASCSAE-DGACHCTPGWTGLFCTQRCPAAFF---GKDCGRVCQCQNGA 759

  Fly   525 -CDLSSGQLVCQEDSDMDYSGENSRYVC 551
             ||..||:..|:    ..::|::....|
Human   760 SCDHISGKCTCR----TGFTGQHCEQRC 783

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NimC1	NP_001260453.1	None
MEGF11	NP_001371957.1	EMI	25..94	CDD:462204	26/72 (36%)
		EGF_CA	275..320	CDD:473889	11/45 (24%)
		EGF_CA	362..409	CDD:473889	6/46 (13%)