Protein Alignment NimC1 and PEAR1

DIOPT Version :10

• Sequence 1: NP_001260453.1
• Gene: NimC1 / 34816
• FlyBaseID: FBgn0259896
• Length: 622
• Species: Drosophila melanogaster
• Sequence 2: XP_016856723.1
• Gene: PEAR1 / 375033
• HGNCID: 33631
• Length: 1125
• Species: Homo sapiens
• Alignment Length: 775
• Identity: 193/775 - (24%)
• Similarity: 255/775 - (32%)
• Gaps: 302/775 - (38%)

  Fly    69 VYEDETAYRTVM------RPSCCEGYEGSVENCKPVCRQQCPQHGFCSSPNTCSCNAGYGGIDCH 127
            ||  .|.||.|:      |..||.|:..|...|.|:|.|:| .||.|.:||.|.|..|:.|.||.
Human   159 VY--RTVYRQVVKTDHRQRLQCCHGFYESRGFCVPLCAQEC-VHGRCVAPNQCQCVPGWRGDDCS 220

  Fly   128 PVC-----------PTVCGKNEFCD-RPGVCSCQNGYKRTSPSDNCL---------PVCEKECGH 171
            ..|           |..||.|..|| :.|||||.:|.:    ..|||         |.|:..|..
Human   221 SECAPGMWGPQCDKPCSCGNNSSCDPKSGVCSCPSGLQ----PPNCLQPCTPGYYGPACQFRCQC 281

  Fly   172 HS--------------------------------FC-------------SEPGKCECEPGYEKVG 191
            |.                                ||             :..|.|.|.||:
Human   282 HGAPCDPQTGACFCPAERTGPSCDVSCSQGTSGFFCPSTHSCQNGGVFQTPQGSCSCPPGW---- 342

  Fly   192 NGTV----FPDGYKNNS--------NG----------NCSP---------ICPK----------- 214
            .||:    .|:|:...:        ||          .|:|         .||.
Human   343 MGTICSLPCPEGFHGPNCSQECRCHNGGLCDRFTGQCRCAPGYTGDRCREECPVGRFGQDCAETC 407

  Fly   215 DCGQNSRCV-RPGVCECENGYAGD--------DG--GTNCRPVCSTCPENGLCLSP--GVCVCKP 266
            ||..::||. ..|.|.||:|:.||        ||  |.:|:..|:...|:.|...|  |.|.|.|
Human   408 DCAPDARCFPANGACLCEHGFTGDRCTDRLCPDGFYGLSCQAPCTCDREHSLSCHPMNGECSCLP 472

  Fly   267 GYV-----------MRNDLCQPHCEKCSDNAHCVAPN-QCECFPGYESSGADKKCVP-------- 311
            |:.           .....||.|| .|.....|.|.: .|:|.|||........|.|
Human   473 GWAGLHCNESCPQDTHGPGCQEHC-LCLHGGVCQATSGLCQCAPGYTGPHCASLCPPDTYGVNCS 536

  Fly   312 -KCSKGCTNGFCFAP--ETCVCSIGYQMGPNQV-CEP-------KCSLNCVHGKCTSPET--CTC 363
             :||  |.|....:|  ..|||..|:|.|...| |.|       ..|..|.|....||:|  |||
Human   537 ARCS--CENAIACSPIDGECVCKEGWQRGNCSVPCPPGTWGFSCNASCQCAHEAVCSPQTGACTC 599

  Fly   364 DPGYRFK-------------------DNSHHE-CDPI-----CDSG------------------C 385
            .||:...                   |..|.: |||:     |.:|                  |
Human   600 TPGWHGAHCQLPCPKGQFGEGCASRCDCDHSDGCDPVHGRCQCQAGWMGARCHLSCPEGLWGVNC 664

  Fly   386 SN-------GHCVAPN-FCICHDGYQLNSTNPVTSMCQPICKGCQFGDCVAPNVCEC-NVGY-EN 440
            ||       |.|:..| .|:|..|::..|       ||..|:..::|....|  |:| |..: ..
Human   665 SNTCTCKNGGTCLPENGNCVCAPGFRGPS-------CQRSCQPGRYGKRCVP--CKCANHSFCHP 720

  Fly   441 INGLCELQTTTDSYEYSTTTVELQSSTVDPQLQTSTSEVPH--SNCTAGCMCWIEYDGMGTFNTA 503
            .||.|        |..:..|....|....|         .|  .||...|.|   :.| ||.:
Human   721 SNGTC--------YCLAGWTGPDCSQPCPP---------GHWGENCAQTCQC---HHG-GTCH-- 762

  Fly   504 KCAKICVDPQDKPCLNLDNCQCDLSSGQLVCQEDSDMDYSGENSRY--------VCHILPEQGA- 559
                    |||..|:      |.|......|.|...:...|.|...        .||  ||.||
Human   763 --------PQDGSCI------CPLGWTGHHCLEGCPLGTFGANCSQPCQCGPGEKCH--PETGAC 811

  Fly   560 -----RSEAEVRI---------PDRTGSSNKWMIIVGSC--AGMIIGVAATIIGIKYYRR 603
                 .|.|..||         |....:.|....::|..  ..:::.:.|..||.:::::
Human   812 VCPPGHSGAPCRIGIQEPFTVMPTTPVAYNSLGAVIGIAVLGSLVVALVALFIGYRHWQK 871