Protein Alignment NimC1 and Megf10

DIOPT Version :10

• Sequence 1: NP_001260453.1
• Gene: NimC1 / 34816
• FlyBaseID: FBgn0259896
• Length: 622
• Species: Drosophila melanogaster
• Sequence 2: NP_001094127.1
• Gene: Megf10 / 291445
• RGDID: 735084
• Length: 1145
• Species: Rattus norvegicus
• Alignment Length: 919
• Identity: 213/919 - (23%)
• Similarity: 291/919 - (31%)
• Gaps: 362/919 - (39%)

  Fly    12 CLSLSFGTSFAILRHGL-----------NDCSHPESVPYNRKVLKSKLVPFQQYSY-----FHGW 60
            ||    |...::|.|.|           |.|||.||  |:..|.:|...||.|..|     ...|
  Rat     8 CL----GLICSLLCHWLRAASSLNLEDPNVCSHWES--YSVTVQESYPHPFDQIYYTSCTDILNW 66

  Fly    61 VTKYRHQYVYEDETAYR----TVMR--PSCCEGYEGSVENCKPVCRQQCPQHGFCSSPNTCSCNA 119
            ....||:..|  .||||    |:.|  ..||.|:..|.:.|.|.|..:| .||.|.:||||.|..
  Rat    67 FKCTRHRVSY--RTAYRHGEKTMYRRKSQCCPGFYESRDVCVPHCADKC-VHGRCIAPNTCQCEP 128

  Fly   120 GYGGIDCH---------PVCPTVCG-KNEFCDRP--GVCSCQNGYKRTSPSDNCLP-----VCEK 167
            |:||.:|.         |.|.:.|. ||.....|  |.|.|..||:.....|.|..     .|.:
  Rat   129 GWGGTNCSSACDGDHWGPHCSSRCQCKNRALCNPITGACHCAAGYRGWRCEDRCEQGTYGNDCHQ 193

  Fly   168 --ECGHHSFCSE-PGKCECEPGYE-----------KVG----------NGTV---------FPDG 199
              :|.:.:.|.. .|:|.|.|||.           |.|          ||.|         .|.|
  Rat   194 RCQCQNGATCDHITGECRCSPGYTGAFCEDLCPPGKHGPQCEQRCPCQNGGVCHHVTGECSCPSG 258

  Fly   200 YKNNSNGNCSPICP-----KDCGQNSRCVRPGVCE-------CENGYAGD---------DGGTNC 243
            :....   |...||     |:|.|..:|...|.|:       |..||.|:         ..|..|
  Rat   259 WMGTV---CGQPCPEGRFGKNCSQECQCHNGGACDAATGQCHCSPGYTGERCQDECPVGTYGVRC 320

  Fly   244 RPVCSTCPENGLC---------------------LSP--------------------------GV 261
            ...| .|...|.|                     |.|                          |.
  Rat   321 AETC-RCVNGGKCYHVSGTCLCEAGFSGEFCEARLCPEGLYGIKCDKRCPCHLDNTHSCHPMSGE 384

  Fly   262 CVCKPGY--VMRNDLCQP-----HCEK---CSDNAHC-VAPNQCECFPGYESSGADKKCVP---- 311
            |.||||:  :..|:.|.|     .|::   |.:.|.| ....:|.|.||::.:.....| |
  Rat   385 CGCKPGWSGLYCNETCSPGFYGEACQQICSCQNGADCDSVSGRCACAPGFKGTDCSTPC-PLGRY 448

  Fly   312 --KCSK--GCTNGFCFAP--ETCVCSIGYQMGPNQVCEPK------CSLNCV---HGKC-TSPET 360
              .||.  ||.|....:|  .:|:|..|:......:..|.      |:|.|.   .|.| |...|
  Rat   449 GINCSSRCGCKNDAVCSPVDGSCICKAGWHGVDCSISCPSGTWGFGCNLTCQCLNGGACNTLDGT 513

  Fly   361 CTCDPGYRFK-------------------DNSHHE-CDPI--------------CDSGCSNG--- 388
            |||.||:|.:                   |.||.: |.|.              |||.|:.|
  Rat   514 CTCAPGWRGEKCEFPCQDGTYGLNCAERCDCSHADGCHPTTGHCRCLPGWSGVHCDSVCAEGRWG 578

  Fly   389 -HCVAPNFC--------------------------ICHDGYQ-----------LNSTNP---VT- 411
             :|..|.:|                          ||..|:.           ::|:.|   :|
  Rat   579 PNCSLPCYCKNGASCSPDDGICECAPGFRGTTCQRICSPGFYGHRCSQTCPQCVHSSGPCHHITG 643

  Fly   412 ----------SMCQPICKGCQFG-DCVAPNVCECNVGYENINGLCE-LQTTTDSYEYSTTTVELQ 464
                      ::|..:|...:|| :|.  .||.|     ..||.|. :..:...|   ...:...
  Rat   644 LCDCLPGFTGALCNEVCPSGRFGKNCA--GVCTC-----TNNGTCNPIDRSCQCY---PGWIGSD 698

  Fly   465 SSTVDPQLQTSTSEVPHSNCTAGCMCWIEYDG--------MGTFNTAKCAKICVDPQDKPCLNLD 521
            .|...|......:.:...||..|..| ..|||        .|.:.|.:|.   :....|.|..:.
  Rat   699 CSQPCPPAHWGPNCIHTCNCHNGAFC-SAYDGECKCTPGWTGLYCTQRCP---LGFYGKDCALVC 759

  Fly   522 NCQ----CDLSSGQLV---------CQEDSDMDYSGENSRYVCHILPE----------------Q 557
            .||    ||..|||..         |::.......|...|.:|..|..                :
  Rat   760 QCQNGADCDHISGQCTCRTGFMGRHCEQKCPAGTYGYGCRQICDCLNNSTCDHITGTCYCSPGWK 824

  Fly   558 GARSEAEVRIPDRTGSSNKWMIIVGSC----------------AGMIIGVAATIIGIKY------ 600
            |||.       |:.|     :||||:.                .|.|.|:...::.:.:
  Rat   825 GARC-------DQAG-----VIIVGNLNSLSRTSTALPADSYQIGAIAGIVVLLLVVLFLLALFV 877

  Fly   601 -YRRSTSRR 608
             ||....|:
  Rat   878 IYRHKQKRK 886

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NimC1	NP_001260453.1	None
Megf10	NP_001094127.1	EMI	31..100	CDD:462204	26/72 (36%)
		EGF_Lam	281..318	CDD:214543	7/36 (19%)
		EGF_CA	542..587	CDD:473889	12/44 (27%)