DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NimC1 and Stab2

DIOPT Version :9

Sequence 1:	NP_001260453.1	Gene:	NimC1 / 34816	FlyBaseID:	FBgn0259896	Length:	622	Species:	Drosophila melanogaster
Sequence 2:	XP_038934441.1	Gene:	Stab2 / 282580	RGDID:	628822	Length:	2569	Species:	Rattus norvegicus

Alignment Length:	961	Identity:	181/961 - (18%)
Similarity:	234/961 - (24%)	Gaps:	526/961 - (54%)

- Green bases have known domain annotations that are detailed below.

  Fly    80 MRPSCCEGYEG-SVENCKPVCRQQCPQHGFC----SSPNTCSCNAGYGGIDCH---------PVC 130
            ::|.||.|:.| ....|....|..|...|.|    ....:|||.||:.|..|.         |.|
  Rat   104 LQPQCCPGHWGPDCMECPGGARAPCGGRGVCDEGMEGTGSCSCQAGFSGTACEACATDNVFGPNC 168

  Fly   131 PTVCG-----KNEFCDRPGVCSCQNGYK--------------------RTSPSD----------- 159
            ..||.     .|...:..|.|.|.:.|:                    |.|||.
  Rat   169 SAVCSCVHGVCNSGLNGDGTCECLSAYRGPKCDKPIPECATLLCPENSRCSPSSKDETKLQCKCL 233

  Fly   160 --------NCLPV--CEKE-CGHHSFCSEPG----KCECEPGYEKVGNGTV-FPDGYKNNSNGNC 208
                    ||.|:  |.|. |..|:.||..|    .|.|:.||:  |:|.| .|......:.|.|
  Rat   234 PNYEGDGHNCRPINPCLKTICHPHASCSYLGPNRHSCICQKGYQ--GDGQVCLPVDPCQTNYGKC 296

  Fly   209 SP---ICPKD---------------------------------CGQNSRC--VRPG--VCECENG 233
            .|   :|..|                                 |.:|:.|  |.||  .|.|:.|
  Rat   297 PPESTVCKYDGPGQSHCECKEHYRNFVPGVGCSMTDICESNNPCHKNANCSTVSPGKTKCTCQKG 361

  Fly   234 YAGDDGGTNCR-----------------------------------PVCSTCP------------ 251
            |.||  |.||.                                   |:.:..|
  Rat   362 YVGD--GLNCYGNIMQRLRELNTEPRGMWQGQLTSFISILDRTYAWPLSNLGPFTVLLPSDKGLK 424

  Fly   252 ----------------------------------------------------------------- 251

  Rat   425 GVDVKELLMDKEAARYFAKLHIIAGQMSMEQMYHLDTFYTLTGKSGEIFNKDKDNQLKLKLHGSK 489

  Fly   252 -----------ENGL-------------------------------------------------- 255
                       .|||
  Rat   490 VVKIIQGNIVASNGLVHILDRAMDKTEPTFASNPQQTIMAMLQPRYGRFRSLLEKTNVGQILDEG 554

  Fly   256 -----------------------CLSP----------------------GVCVCKP--------- 266
                                   .|||                      ...|..|
  Rat   555 GPYTIFVPSNEALSNMKADILDYLLSPEGSRKLLELVRYHIVAFTQLEVATLVSTPHIRSMANQI 619

  Fly   267 --------GYVMRNDLCQ----------------------------PH-------------CEKC 282
                    |.::.|::..                            ||             |..|
  Rat   620 IKFNITSKGQILANNVAMDETEVAAKNGRIYTLTGVLIPPSILPILPHRCNETKIELKLGTCVSC 684

  Fly   283 SDN--AHCVAPNQ-----CECFPGYES------SGADKKC-----VPKCSKG-----CT------ 318
            |..  :.|.|.::     ..||  |.|      ||..:.|     :|:|.||     ||
  Rat   685 STKHWSKCPADSKPATIFSSCF--YSSRVRNLKSGCARYCNVTVEIPRCCKGFFGPDCTPCPGGF 747

  Fly   319 ------NGFCF----APETCVCSIGYQMGPNQVCE------PKCSLN--CVHGKCTSPETCTCDP 365
                  ||.|.    ...||:|..|:|....|.|.      |:|:..  ||||        |||
  Rat   748 LTPCSGNGQCMDGLAGNGTCICQDGFQGSMCQFCSDPNRYGPRCNRTCLCVHG--------TCD- 803

  Fly   366 GYRFKDNSHHECDPICDSG-CSNGHCVAPNFCICHDGYQLNSTNPVTSMCQPICKGCQFGDCVAP 429
                   :..:.|..|.|| |..|  .|..||    ..|.::..|....|. |...|::.:..|.
  Rat   804 -------NRLDSDGACLSGTCREG--TAGRFC----DKQTSACGPYVQFCH-IHASCEYSNKTAS 854

  Fly   430 NVCECNVGYENINGLCE--------------------LQTTTDSYEYSTTTVELQSSTVDPQLQT 474
              |.||.|||....||.                    :||:|.:|           |.|..|..|
  Rat   855 --CVCNEGYEGDGVLCSKKDPCLGLTSRGGCSPNAECIQTSTGTY-----------SCVCQQGWT 906

  Fly   475 STSE--VPHSNC----TAGC----MCWIEYDGMGTFNTAKCAK-------------ICVDPQDKP 516
            ....  |..:||    :.||    .|.  |.|.|. |..:|.|             .|::..:|
  Rat   907 GNGRDCVGINNCLLPSSGGCHDNATCL--YVGPGQ-NECECKKGFRGNGIDCEPIISCLEQTEK- 967

  Fly   517 CLNLDNCQCDLSSG--QLVCQEDSDMDYSGENSRYVCHILPEQGARSEAEV 565
            |..|..|| ..|||  ..||:|    .|.|.......::|.|.....||.|
  Rat   968 CHPLATCQ-STSSGVWSCVCRE----GYEGNGVLCYGNVLMELSFLPEAAV 1013

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NimC1	NP_001260453.1	None
Stab2	XP_038934441.1	EGF_CA	254..283	CDD:419698	11/30 (37%)
		EGF_3	334..369	CDD:403986	13/36 (36%)
		Fasciclin	390..512	CDD:396845	5/121 (4%)
		Fasciclin	533..658	CDD:396845	7/124 (6%)
		EGF_3	840..868	CDD:403986	10/30 (33%)
		EGF_3	881..912	CDD:403986	8/41 (20%)
		EGF_3	923..955	CDD:403986	9/34 (26%)
		EGF_3	961..997	CDD:403986	14/41 (34%)
		Fasciclin	1014..1133	CDD:396845	181/961 (19%)
		Fasciclin	1152..1269	CDD:396845
		EGF_3	1478..1514	CDD:403986
		EGF_3	1520..1556	CDD:403986
		EGF_3	1562..1598	CDD:403986
		Fasciclin	1629..1729	CDD:396845
		Fasciclin	1754..1885	CDD:396845
		EGF_CA	2059..2084	CDD:419698
		EGF_3	2090..2125	CDD:403986
		EGF_3	2131..2168	CDD:403986
		Link_Domain	2202..2294	CDD:413401
		FAS1	2360..2449	CDD:214719
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1218
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900