DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NimC1 and Megf6

DIOPT Version :9

Sequence 1:	NP_001260453.1	Gene:	NimC1 / 34816	FlyBaseID:	FBgn0259896	Length:	622	Species:	Drosophila melanogaster
Sequence 2:	NP_001156449.1	Gene:	Megf6 / 230971	MGIID:	1919351	Length:	1572	Species:	Mus musculus

Alignment Length:	839	Identity:	194/839 - (23%)
Similarity:	252/839 - (30%)	Gaps:	312/839 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 FVCLSLSF--------------GTSFAILRHGLNDCSHPESVPYNRKVLKSKLVPFQQYSYFHGW 60
            ||||..||              ||.|.    ||:.|..||                       ||
Mouse   511 FVCLDHSFGHDCSLTCDDCRNGGTCFP----GLDGCDCPE-----------------------GW 548

  Fly    61 VTKYRHQYVYEDETAYRTVMRPSCCEGYEGSVENCKPV--------------CRQQCPQHGF--- 108
            .....::....| |..:....|..|:  .|.  .|.||              |...||: ||
Mouse   549 TGIICNETCPPD-TFGKNCSSPCICQ--NGG--TCDPVSGACRCPPGVSGAHCEDGCPK-GFYGK 607

  Fly   109 -----CSSPN---------TCSCNAGYGGIDCHPVCP-----TVCGKNEFCD---------RPGV 145
                 |...|         .|.|:.|..|..||..||     ..|.::..|:         :.|.
Mouse   608 HCRKKCHCANRGRCHRLYGACLCDPGLYGRFCHLACPPWAFGPGCSEDCLCEQSHTRSCNSKDGS 672

  Fly   146 CSCQNGYKRTSPSDNCLPVCEKECGHHSFCSEPG---KCECEPGY--EKVGN--GTVFPDGYKNN 203
            |||:.|::...        ||.||...||  .||   :|.|.||.  :.|..  .|..|.||:..
Mouse   673 CSCKAGFQGER--------CEAECEPGSF--GPGCRNRCTCRPGVACDPVSGECRTQCPPGYQGE 727

  Fly   204 SNGNCSPICP-----KDCGQNSRCVR------PGVCECENGYAGDDGGTN---------CRPVCS 248
               :|...||     .:|..:..||.      .|.|.|..|..|:|.|.:         |:.:|.
Mouse   728 ---DCGQECPVGTFGVNCSGSCSCVGAPCHRVTGECLCPPGKTGEDCGADCPEGRWGLGCQEICP 789

  Fly   249 TCPENGLCLSP--GVCVCKPGYVMRNDLCQPHCE------------KCSDNAHC-VAPNQCECFP 298
            .| |:|....|  |.|:|.||:|  ...||..|.            .|:::.|| .|..:|.|.|
Mouse   790 AC-EHGASCDPETGTCLCLPGFV--GSRCQDACPAGWFGTGCQMRCACANDGHCHPATGRCSCAP 851

  Fly   299 GYESSGADKKC-----VPKCSKGCT----NGFCFAPE-TCVCSIGYQ------------MGPNQV 341
            |:......:.|     .|.|...|.    :|.|.|.. .|:|..||:            .||.
Mouse   852 GWTGLSCQRACDSGHWGPDCIHPCNCSAGHGNCDAVSGLCLCEAGYEGPQCEQWCRQGYFGPG-- 914

  Fly   342 CEPKCSLNCVHG-KCTSPE-TCTCDPGYRFKDNSHHECDPI------CDSGCS----------NG 388
            ||.||  .|.|| .|.... .|||..|:| .....|.| |.      |.|.|:          .|
Mouse   915 CEQKC--RCEHGATCDHVSGACTCPAGWR-GSFCEHAC-PAGFFGLDCGSACNCSAGAPCDAVTG 975

  Fly   389 HCVAP----------------------NFCICHDGYQLNSTNPVTSMCQ-------PIC------ 418
            .|:.|                      ..|.|.:|   .|.:||...|.       |.|
Mouse   976 SCICPAGRWGPHCAQTCPPLTFGLNCSQICTCFNG---ASCDPVLGQCHCAPGWMGPTCLQACPA 1037

  Fly   419 ----KGCQ--------------FGDCVAPN-----VCE-----------CNVGYENIN-GLCELQ 448
                |.||              .|.|..|.     .||           |.:....:| |.|:..
Mouse  1038 GLYGKNCQHSCLCRNGGNCDPILGQCTCPEGWTGLACENECLPGHHGAGCRLNCSCLNGGTCDRL 1102

  Fly   449 TTTDSYEYSTTTVELQSSTVDPQLQTSTSEVPHSNC---------TAGCMCWIEYDG-------- 496
            |.........|..:.||..|.........|  |..|         |..|:|...:.|
Mouse  1103 TGHCRCPTGWTGDKCQSPCVSGMFGVHCEE--HCACRKGATCHHVTGACLCPPGWRGSHCEQACP 1165

  Fly   497 MGTFNTAKCAKICVDPQDKPCLNLD-NCQCDLSSGQLVCQEDSDMDYSGENSRYVCHILPEQGAR 560
            .|.|..| ||:.|..|....|.::. .|.|........|::.......|::..:.|....|..|.
Mouse  1166 RGWFGEA-CAQRCHCPPGASCHHVSGECHCPPGFTGPGCEQACQPGTFGKDCEHPCQCPGETWAC 1229

  Fly   561 SEAEVRIPDRTGSSNKWMIIVGSCAGMIIGVAATIIGIKYYRRSTSRRNFEAEEAIVEC 619
            ..|.                 |:|.     .||...|....:|..|.|.....|.|.:|
Mouse  1230 HPAS-----------------GACV-----CAAGYHGTDCQQRCPSGRYGPGCEQICKC 1266

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID
NimC1	NP_001260453.1	None
Megf6	NP_001156449.1	EMI	42..111	CDD:284877
		FXa_inhibition	126..161	CDD:291342
		vWFA	<153..201	CDD:294047
		vWFA	<236..284	CDD:294047
		vWFA	<283..324	CDD:294047
		FXa_inhibition	337..372	CDD:291342
		vWFA	<370..409	CDD:294047
		vWFA	<412..451	CDD:294047
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1218
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900