DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment NimC1 and Tnfrsf1b

DIOPT Version :9

Sequence 1:	NP_001260453.1	Gene:	NimC1 / 34816	FlyBaseID:	FBgn0259896	Length:	622	Species:	Drosophila melanogaster
Sequence 2:	NP_035740.2	Gene:	Tnfrsf1b / 21938	MGIID:	1314883	Length:	474	Species:	Mus musculus

Alignment Length:	336	Identity:	70/336 - (20%)
Similarity:	103/336 - (30%)	Gaps:	112/336 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   225 PGV-CECENGYAGDDGGTNCRPVCSTCPENGLCLSPGVCVCKPGYVMRNDLCQPHCEKCSDN--A 286
            ||. |:....|. |.....|   |:.||              ||..:::     .|.|.||.  |
Mouse    36 PGYECQISQEYY-DRKAQMC---CAKCP--------------PGQYVKH-----FCNKTSDTVCA 77

  Fly   287 HCVAPNQCECFPGYESSGADKKCVPKCSKGCTNG-----FCFAPETCVCSIGYQMGPNQVCEP-- 344
            .|.|....:.:..:      :.|: .||..||..     .|...:..||:          ||.
Mouse    78 DCEASMYTQVWNQF------RTCL-SCSSSCTTDQVEIRACTKQQNRVCA----------CEAGR 125

  Fly   345 KCSLNCVHGKCTSPETC----TCDPGYRFKDNSHHECDPICDSGCSNGH--CVAPNFCICHDGYQ 403
            .|:|....|.|   ..|    .|.||:           .:..|...||:  |.|     |..| .
Mouse   126 YCALKTHSGSC---RQCMRLSKCGPGF-----------GVASSRAPNGNVLCKA-----CAPG-T 170

  Fly   404 LNSTNPVTSMCQPICKGCQFGDCVAPNVCECNV--GYENINGLCELQTTTDSYEYSTTTVE---- 462
            .:.|...|.:|:|            ..:|....  |..:.:.:|..::.|.|....|..|.
Mouse   171 FSDTTSSTDVCRP------------HRICSILAIPGNASTDAVCAPESPTLSAIPRTLYVSQPEP 223

  Fly   463 LQSSTVD--------PQLQTSTSEVP--------HSNCTAGCMCWIEYDGMGTFNTAKCAKICVD 511
            .:|..:|        |.:.||....|        ..:...|.:..:...|:.......|. |.|.
Mouse   224 TRSQPLDQEPGPSQTPSILTSLGSTPIIEQSTKGGISLPIGLIVGVTSLGLLMLGLVNCI-ILVQ 287

  Fly   512 PQDKP-CLNLD 521
            .:.|| ||..|
Mouse   288 RKKKPSCLQRD 298

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NimC1	NP_001260453.1	None
Tnfrsf1b	NP_035740.2	TNFR-Cys 1	39..77		13/60 (22%)
		TNFRSF1B	40..203	CDD:276903	47/234 (20%)
		CRD1	40..76	CDD:276903	13/58 (22%)
		TNFR-Cys 2	78..119		8/47 (17%)
		CRD2	79..119	CDD:276903	8/46 (17%)
		TNFR-Cys 3	120..164		13/67 (19%)
		CRD3	121..145	CDD:276903	7/26 (27%)
		CRD4	163..203	CDD:276903	10/57 (18%)
		TNFR-Cys 4	165..203		9/55 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	220..243		3/22 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	295..314		2/4 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	321..378
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	397..463
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000