Protein Alignment NimC1 and MEGF6

DIOPT Version :10

• Sequence 1: NP_001260453.1
• Gene: NimC1 / 34816
• FlyBaseID: FBgn0259896
• Length: 622
• Species: Drosophila melanogaster
• Sequence 2: XP_011539188.1
• Gene: MEGF6 / 1953
• HGNCID: 3232
• Length: 1560
• Species: Homo sapiens
• Alignment Length: 795
• Identity: 185/795 - (23%)
• Similarity: 236/795 - (29%)
• Gaps: 328/795 - (41%)

  Fly    10 FVCLSLSFGTSFAI----LRH------GLNDCSHPESVPYNRKVLKSKLVPFQQYSYFHGWVTKY 64
            ||||..|||...::    .|:      ||:.|..||                       ||.
Human   571 FVCLDDSFGHDCSLTCDDCRNGGTCLLGLDGCDCPE-----------------------GWT--- 609

  Fly    65 RHQYVYEDETAYRTVMRPSCCEGYEGSVENCKPVCRQQCPQHGFCSS-PNTCSCNAGYGGIDCHP 128
                        ..:...:|.....|  :||...|  .|...|.|.| ...|.|..|..|.:|..
Human   610 ------------GLICNETCPPDTFG--KNCSFSC--SCQNGGTCDSVTGACRCPPGVSGTNCED 658

  Fly   129 VCP-----------TVCGKNEFCDR-PGVCSCQNG-YKR----TSPSDNCLPVCEKEC----GHH 172
            .||           ..|.....|.| .|.|.|..| |.|    |.|.....|.|.:||    .|.
Human   659 GCPKGYYGKHCRKKCNCANRGRCHRLYGACLCDPGLYGRFCHLTCPPWAFGPGCSEECQCVQPHT 723

  Fly   173 SFCSE-PGKC-------------ECEPGYEKVG--NGTVFPDGYKNNS-NGNCSPICP-----KD 215
            ..|.: .|.|             |||.||...|  .....|.|...:| :|.|...||     :|
Human   724 QSCDKRDGSCSCKAGFRGERCQAECELGYFGPGCWQACTCPVGVACDSVSGECGKRCPAGFQGED 788

  Fly   216 CGQ-----------NSRCVRPGV--------CECENGYAGDD---------GGTNCRPVCSTCPE 252
            |||           :|.|...|.        |.|..|..|:|         .|..|:.:|..|..
Human   789 CGQECPVGTFGVNCSSSCSCGGAPCHGVTGQCRCPPGRTGEDCEADCPEGRWGLGCQEICPACQH 853

  Fly   253 NGLCLSP--GVCVCKPGYV--MRNDLCQ-----PHCE---KCSDNAHC-VAPNQCECFPGYESSG 304
            ...| .|  |.|:|.||:|  ...|:|.     |.|:   .|:::.|| .|...|.|.||:....
Human   854 AARC-DPETGACLCLPGFVGSRCQDVCPAGWYGPSCQTRCSCANDGHCHPATGHCSCAPGWTGFS 917

  Fly   305 ADKKC-----VPKCSKGCT----NGFCFA-PETCVCSIGY------------QMGPNQVCEPKCS 347
            ..:.|     .|.||..|.    :|.|.| ...|:|..||            ..||.  ||.:|
Human   918 CQRACDTGHWGPDCSHPCNCSAGHGSCDAISGLCLCEAGYVGPRCEQQCPQGHFGPG--CEQRC- 979

  Fly   348 LNCVHGKCTS--PETCTCDPGYR--FKDNSHHECDPI------CDSGCS----------NGHCVA 392
             .|.||....  ...|||..|:|  |   ..|.| |.      |.|.|:          ||.|:.
Human   980 -QCQHGAACDHVSGACTCPAGWRGTF---CEHAC-PAGFFGLDCRSACNCTAGAACDAVNGSCLC 1039

  Fly   393 P----------------------NFCICHDGYQLNSTNPVTSMCQ-------PIC-KGCQ---FG 424
            |                      ..|.|.:|   .|.:||...|.       |.| :.|.   :|
Human  1040 PAGRRGPRCAETCPAHTYGHNCSQACACFNG---ASCDPVHGQCHCAPGWMGPSCLQACPAGLYG 1101

  Fly   425 D-----CVAPN---------VCECNVGYENI-----------------------NGLCELQTTTD 452
            |     |:..|         .|.|..|:..:                       .|||:
Human  1102 DNCRHSCLCQNGGTCDPVSGHCACPEGWAGLACEKECLPRDVRAGCRHSGGCLNGGLCD------ 1160

  Fly   453 SYEYSTTTVELQSSTVDPQLQTSTSEVPHSNCTAGCMCWIEYDG--------MGTFNTAKCAKIC 509
                                       ||   |..|:|...:.|        .|.|..| ||:.|
Human  1161 ---------------------------PH---TGRCLCPAGWTGDKCQSPCLRGWFGEA-CAQRC 1194

  Fly   510 VDPQDKPCLNLDN-CQCD---LSSGQLVCQEDSDMDYSGENSRYVCHILPEQGARSEAEVRIPDR 570
            ..|....|.::.. |:|.   ..||   |::.......||:...:|....|..|...|
Human  1195 SCPPGAACHHVTGACRCPPGFTGSG---CEQACPPGSFGEDCAQMCQCPGENPACHPA------- 1249

  Fly   571 TGSSNKWMIIVGSCA 585
            ||:.        |||
Human  1250 TGTC--------SCA 1256

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NimC1	NP_001260453.1	None
MEGF6	XP_011539188.1	EMI	107..176	CDD:462204
		vWFA	<215..261	CDD:469594
		FXa_inhibition	268..304	CDD:464251
		vWFA	<342..384	CDD:469594
		FXa_inhibition	397..432	CDD:464251
		vWFA	<472..511	CDD:469594