DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment NimB5 and Pear1

DIOPT Version :9

Sequence 1:	NP_001188802.1	Gene:	NimB5 / 34815	FlyBaseID:	FBgn0028936	Length:	315	Species:	Drosophila melanogaster
Sequence 2:	NP_001027585.1	Gene:	Pear1 / 73182	MGIID:	1920432	Length:	1034	Species:	Mus musculus

Alignment Length:	403	Identity:	96/403 - (23%)
Similarity:	129/403 - (32%)	Gaps:	175/403 - (43%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 SQDPGMGTYGRGYMENRQLSYNRPG---PAN-----FQDPRNVELQPKRREYLIRSHETQSDRGQ 95
            |.||.:.|:...:....:.|:.||.   ||.     ::||
Mouse    21 SNDPNVCTFWESFTTTTKESHLRPFSLLPAESCHRPWEDP------------------------- 60

  Fly    96 HKCRIWVPPDTVEKYSYPSVIQTDQANRLSLIEVCCTGYSASRLMGVTVCRAQCGCQNGSCKIPG 160
            |.|   ..|..|.:..|..|::.|...||.    ||.||..||...|.:|..:  |.:|.|..|.
Mouse    61 HTC---AQPTVVYRTVYRQVVKMDSRPRLQ----CCRGYYESRGACVPLCAQE--CVHGRCVAPN 116

  Fly   161 ECECYDGFVRND------------------------------------NG----DCVFACPLG-- 183
            :|:|..|:...|                                    :|    :|:..||.|
Mouse   117 QCQCAPGWRGGDCSSECAPGMWGPQCDKFCHCGNNSSCDPKSGTCFCPSGLQPPNCLQPCPAGHY 181

  Fly   184 ---CQ-NGQCY------LDGSCQCDPGYKLDETRRFCRPICSSG-----------C--GSSP--- 222
               || :.|||      .||:|.|.||    .....|...||.|           |  |..|
Mouse   182 GPACQFDCQCYGASCDPQDGACFCPPG----RAGPSCNVPCSQGTDGFFCPRTYPCQNGGVPQGS 242

  Fly   223 RHNCTEPE-----ICG--CSKGYQLTDDGCQPVCEPDCGIGGLC-KDNNQCDCAPGYNLRDGVCQ 279
            :.:|:.|.     ||.  |.:|:.  ...|...|.  |..|||| :...||.||||| :.|. ||
Mouse   243 QGSCSCPPGWMGVICSLPCPEGFH--GPNCTQECR--CHNGGLCDRFTGQCHCAPGY-IGDR-CQ 301

  Fly   280 ---------ADCYQKCN----------NGVCV-----------------------SRNRCLCDPG 302
                     .||.:.|:          ||.|:                       .:..|.|||
Mouse   302 EECPVGRFGQDCAETCDCAPGARCFPANGACLCEHGFTGDRCTERLCPDGRYGLSCQEPCTCDP- 365

  Fly   303 YTYHEQSTMCVPV 315
                |.|..|.|:
Mouse   366 ----EHSLSCHPM 374

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NimB5	NP_001188802.1	None
Pear1	NP_001027585.1	EMI	25..93	CDD:284877	20/99 (20%)
		EGF_CA	535..580	CDD:304395
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	823..883
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	925..1034
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1218
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810