DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NimB4 and TNC

DIOPT Version :9

Sequence 1:	NP_788046.1	Gene:	NimB4 / 34814	FlyBaseID:	FBgn0028542	Length:	448	Species:	Drosophila melanogaster
Sequence 2:	XP_016870167.1	Gene:	TNC / 3371	HGNCID:	5318	Length:	2384	Species:	Homo sapiens

Alignment Length:	400	Identity:	106/400 - (26%)
Similarity:	148/400 - (37%)	Gaps:	114/400 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 RELLREHEALQRRLSSSTTTRKPYIIPNGLSLPRRGEHPDKCRQEVPAVFFQYDKEVKIVGNSST 115
            :|||...|.|:..:||   .|:......|.           |.|  ||           .|...|
Human   120 KELLSRLEELENLVSS---LREQCTAGAGC-----------CLQ--PA-----------TGRLDT 157

  Fly   116 NPYMNVIEVCCKGWRRYEYDWSQCV------------PDCGERCQENGFCVAGGKCVCFTDFVLN 168
            .|:       |.|...:..:...||            |:|...|...|.|: .|:|:|...|.
Human   158 RPF-------CSGRGNFSTEGCGCVCEPGWKGPNCSEPECPGNCHLRGRCI-DGQCICDDGFT-- 212

  Fly   169 YRNNCVP-TCPLGC-PHGRCYLNGTCQCDKGYE-LDGSRKFCQPQCNATCGHNEVCLEPGKCSCA 230
             ..:|.. .||..| ..|:| :||.|.|.:||. .|.||:.|...|:...|   .|:: |.|.|.
Human   213 -GEDCSQLACPSDCNDQGKC-VNGVCICFEGYAGADCSREICPVPCSEEHG---TCVD-GLCVCH 271

  Fly   231 EGYTRGLRESAALGC-QPICIPDC-GYGHCVRPNECECFPGFQKRK-NGITCEGDCY-------- 284
            :|:       |...| :|:|:.:| ..|.||. |||.|..||.... :.:.|..||:
Human   272 DGF-------AGDDCNKPLCLNNCYNRGRCVE-NECVCDEGFTGEDCSELICPNDCFDRGRCING 328

  Fly   285 -MTCENGF----CANKT--------------TCVCQNGYR-YDKNTTTCLPDCGDNCDNGVCISP 329
             ..||.||    |...|              .|||..|:. .|.:...|..||.   :.|.|:.
Human   329 TCYCEEGFTGEDCGKPTCPHACHTQGRCEEGQCVCDEGFAGVDCSEKRCPADCH---NRGRCVD- 389

  Fly   330 GNCRCFKGYVRNRERCEAVCVGGCGFYGKCI-APNVC-------GCAIVPGPERTYQRCEYGLCN 386
            |.|.|..|:. ..:..|..|..||..:|:|: ...||       .|:.:..|...:.|   |.|
Human   390 GRCECDDGFT-GADCGELKCPNGCSGHGRCVNGQCVCDEGYTGEDCSQLRCPNDCHSR---GRC- 449

  Fly   387 AMGRCRCQVG 396
            ..|:|.|:.|
Human   450 VEGKCVCEQG 459

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NimB4	NP_788046.1	None
TNC	XP_016870167.1	EGF_2	377..403	CDD:285248	9/30 (30%)
		EGF_2	408..434	CDD:285248	7/25 (28%)
		EGF_2	468..496	CDD:285248
		EGF_2	504..527	CDD:285248
		EGF_2	533..558	CDD:285248
		fn3	624..695	CDD:306538
		fn3	713..793	CDD:306538
		fn3	804..884	CDD:306538
		fn3	894..976	CDD:306538
		fn3	986..1064	CDD:306538
		fn3	1075..1154	CDD:306538
		fn3	1169..1241	CDD:306538
		fn3	1260..1327	CDD:306538
		fn3	1348..1427	CDD:306538
		fn3	1439..1508	CDD:306538
		fn3	1533..1605	CDD:306538
		fn3	1619..1691	CDD:306538
		fn3	1716..1788	CDD:306538
		fn3	1804..1883	CDD:306538
		fn3	1894..1973	CDD:306538
		fn3	1985..2055	CDD:306538
		fn3	2071..2143	CDD:306538
		Fibrinogen_C	2163..2372	CDD:278572
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910