DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment NimB4 and Megf10

DIOPT Version :9

Sequence 1:	NP_788046.1	Gene:	NimB4 / 34814	FlyBaseID:	FBgn0028542	Length:	448	Species:	Drosophila melanogaster
Sequence 2:	NP_001094127.1	Gene:	Megf10 / 291445	RGDID:	735084	Length:	1145	Species:	Rattus norvegicus

Alignment Length:	490	Identity:	110/490 - (22%)
Similarity:	158/490 - (32%)	Gaps:	189/490 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    86 GEHPDKCRQEVPAVFFQYDKEVKIVGNSSTNPYMNVIEVCCKGWR-----------RYEYDWSQC 139
            |:|..:|.|..|.            .|.....::.....|..||.           |:   ...|
  Rat   228 GKHGPQCEQRCPC------------QNGGVCHHVTGECSCPSGWMGTVCGQPCPEGRF---GKNC 277

  Fly   140 VPDCGERCQENGFC-VAGGKCVCFTDFVLNYRNNCVPTCPLG-----------CPH-GRCY-LNG 190
            ..:|  :|...|.| .|.|:|.|...:.   ...|...||:|           |.: |:|| ::|
  Rat   278 SQEC--QCHNGGACDAATGQCHCSPGYT---GERCQDECPVGTYGVRCAETCRCVNGGKCYHVSG 337

  Fly   191 TCQCDKGY-------------------------ELDGSRKFCQPQ--------------CNATCG 216
            ||.|:.|:                         .||.:.. |.|.              ||.||.
  Rat   338 TCLCEAGFSGEFCEARLCPEGLYGIKCDKRCPCHLDNTHS-CHPMSGECGCKPGWSGLYCNETCS 401

  Fly   217 ---HNEVCLE-------------PGKCSCAEGY------------TRGLRESAALGCQ--PICIP 251
               :.|.|.:             .|:|:||.|:            ..|:..|:..||:  .:|.|
  Rat   402 PGFYGEACQQICSCQNGADCDSVSGRCACAPGFKGTDCSTPCPLGRYGINCSSRCGCKNDAVCSP 466

  Fly   252 DCGYGHCVRPNECECFPGFQKRKNGITCEG-----DCYMTCE--NGFCANKT--TCVCQNGYRYD 307
            ..|        .|.|..|:......|:|..     .|.:||:  ||...|..  ||.|..|:|.:
  Rat   467 VDG--------SCICKAGWHGVDCSISCPSGTWGFGCNLTCQCLNGGACNTLDGTCTCAPGWRGE 523

  Fly   308 KNTTTCLP-----DCGDNCD----NGVCISPGNCRCFKGYVRNRERCEAVCVGG-----CGF--- 355
            |....|..     :|.:.||    :|...:.|:|||..|:  :...|::||..|     |..
  Rat   524 KCEFPCQDGTYGLNCAERCDCSHADGCHPTTGHCRCLPGW--SGVHCDSVCAEGRWGPNCSLPCY 586

  Fly   356 --YGKCIAPN--VCGCAIVPG---------------PERTYQRC-----EYGLCNAM-GRCRCQV 395
              .|...:|:  :|.||  ||               ..|..|.|     ..|.|:.: |.|.|..
  Rat   587 CKNGASCSPDDGICECA--PGFRGTTCQRICSPGFYGHRCSQTCPQCVHSSGPCHHITGLCDCLP 649

  Fly   396 GMT-----------RFIDRCMSPDTVTTYASMNPV 419
            |.|           ||...|....|.|...:.||:
  Rat   650 GFTGALCNEVCPSGRFGKNCAGVCTCTNNGTCNPI 684

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NimB4	NP_788046.1	None
Megf10	NP_001094127.1	EMI	32..99	CDD:400092
		EGF_Lam	281..318	CDD:214543	12/41 (29%)
		EGF_CA	542..587	CDD:419698	13/46 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1218
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810