DRSC/TRiP Functional Genomics Resources

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Protein Alignment NimB1 and Megf10

DIOPT Version :9

Sequence 1:NP_001260452.1 Gene:NimB1 / 34813 FlyBaseID:FBgn0027929 Length:403 Species:Drosophila melanogaster
Sequence 2:NP_001001979.1 Gene:Megf10 / 70417 MGIID:2685177 Length:1147 Species:Mus musculus


Alignment Length:376 Identity:105/376 - (27%)
Similarity:137/376 - (36%) Gaps:133/376 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly    91 CCAGYR---------RDPYANECVPDCSASSPDNCRN--GFCR-SPGVCECFAEFV--RNEHGA- 140
            |.||||         :..|.|:|...|...:...|.:  |.|| |||....|.|.:  ..:||. 
Mouse   169 CAAGYRGWRCEDRCEQGTYGNDCHQRCQCQNGATCDHITGECRCSPGYTGAFCEDLCPPGKHGPH 233

  Fly   141 CIHTCPIACQHGR-C-YLNGTCVCHQNFVLDQETRQFCRPK------CSQSCGTHE--EC-VAPG 194
            |...||  ||:|. | ::.|.|.|...: :.....|.| |:      |||.|..|.  .| .|.|
Mouse   234 CEQRCP--CQNGGVCHHVTGECSCPSGW-MGTVCGQPC-PEGRFGKNCSQECQCHNGGTCDAATG 294

  Fly   195 QCDCSPGY--RRTPD---LGCQPV-CAPDC---GFGKCV-APNQCECFAGF-------------- 235
            ||.|||||  .|..|   :|...| ||..|   ..|||. ....|.|.|||              
Mouse   295 QCHCSPGYTGERCQDECPVGSYGVRCAEACRCVNGGKCYHVSGTCLCEAGFSGELCEARLCPEGL 359

  Fly   236 --IK------------------------RPNWN---------------VCEAECYLNCENGL-CE 258
              ||                        :|.|:               .|:..|  :|:||. |:
Mouse   360 YGIKCDKRCPCHLDNTHSCHPMSGECGCKPGWSGLYCNETCSPGFYGEACQQIC--SCQNGADCD 422

  Fly   259 S-RYKCHCREGY------------RYDVNTTSCLPECSDNCGQGNGVCIAP--GVCRCFRGYEVH 308
            | ..:|.|..|:            ||.:|       ||..||..|....:|  |.|.|..|:  |
Mouse   423 SVTGRCACAPGFKGTDCSTPCPLGRYGIN-------CSSRCGCKNDAVCSPVDGSCICKAGW--H 478

  Fly   309 GAECRPKCESRFCGKYGRCVAPEICGCGEGQQHCRNGSCDDIE-HCSCPSG 358
            |.:|..:|.|   |.:|       .||....|....|:|:.:: .|:|..|
Mouse   479 GVDCSIRCPS---GTWG-------FGCNLTCQCLNGGACNTLDGTCTCAPG 519

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NimB1NP_001260452.1 None
Megf10NP_001001979.1 Necessary for interaction with AP2M1, self-assembly and formation of the irregular, mosaic-like adhesion pattern. /evidence=ECO:0000250|UniProtKB:Q96KG7 1..857 105/376 (28%)
EMI 32..99 CDD:284877
EGF_CA 281..326 CDD:304395 19/44 (43%)
EGF_CA 542..587 CDD:304395
Necessary for formation of large intracellular vacuoles. /evidence=ECO:0000250|UniProtKB:Q96KG7 945..1147
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1093..1147
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1218
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.810

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