DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment NimB1 and stab1

DIOPT Version :9

Sequence 1:	NP_001260452.1	Gene:	NimB1 / 34813	FlyBaseID:	FBgn0027929	Length:	403	Species:	Drosophila melanogaster
Sequence 2:	NP_001182543.1	Gene:	stab1 / 570626	ZFINID:	ZDB-GENE-050208-554	Length:	2553	Species:	Danio rerio

Alignment Length:	349	Identity:	89/349 - (25%)
Similarity:	115/349 - (32%)	Gaps:	107/349 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    75 PVRGNGSTIYFHRIEVCCAGYRRDPYANE--------------------CVPDCSASSPDN--CR 117
            |:...||| ..:|..:|...||  ||...                    |...|:..:.|.  |:
Zfish  1890 PLCPYGST-DMNRTSICRQPYR--PYRMPNYYGMYSYGYGYRSYRDFLGCDRVCTKLTWDTKCCK 1951

  Fly   118 NGFCRSPGVCECFAEFVRNEHGACIHTCPIACQHGRCYLNGTCVCHQNFVLDQETRQFCR----- 177
            |.|.|...||....|....|||.|...     |.|    .|.|.||..|     |.:.|.
Zfish  1952 NHFGRDCQVCSGGLEAPCGEHGDCDDG-----QGG----TGVCKCHTGF-----TGKGCELCLAN 2002

  Fly   178 ---PKCSQ-SCGTHEEC----VAPGQCDCSPGYRRTPDLG--CQ------PVCAPDCGFGK-CVA 225
               |.|:. :|..|.:|    ...|.|.|..|:     :|  ||      .:|:|.|.... |:.
Zfish  2003 HFGPNCTACNCTIHGKCDEGLDGDGSCFCQEGW-----MGESCQTAIEVKSICSPACDLNAVCLP 2062

  Fly   226 PNQCECFAGFIKRPNWNVCEAECYLNCENGLCES---------RYKCHCREGYRYDVNT----TS 277
            .|||||...:  ..|...|.|....:..||.|..         ...|.|:.||..|.:.    ..
Zfish  2063 ENQCECLEPY--EGNGINCTAPDLCSEYNGGCHEEADCMQSGINITCSCQTGYSGDGHVCEPINR 2125

  Fly   278 CLPECSDNCGQGNGVCIAPGV----CRCFRGYEVHGAECRPKCESRFCGKYGRCVAPEICGCGEG 338
            |:.|.:..|.. ...||..|.    |:|..||..:|.:|..|            |.|.:..|.|.
Zfish  2126 CVEEANGGCSD-FAKCIFTGPNERRCQCLDGYVGNGVQCLEK------------VVPPVDRCLED 2177

  Fly   339 QQHCRNGSCDDIEHCSCPSGETHF 362
                 ||.||....|.    :.||
Zfish  2178 -----NGGCDPKAICR----DLHF 2192

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NimB1	NP_001260452.1	None
stab1	NP_001182543.1	EGF_3	227..257	CDD:289699
		Fasciclin	379..475	CDD:295423
		FAS1	455..630	CDD:225214
		Fasciclin	504..630	CDD:280607
		EGF_3	819..847	CDD:289699
		EGF_3	859..889	CDD:289699
		EGF_3	901..932	CDD:289699
		EGF_3	938..974	CDD:289699
		Fasciclin	1002..1103	CDD:280607
		Fasciclin	1125..1242	CDD:295423
		EGF_3	1458..1494	CDD:289699
		EGF_3	1500..1536	CDD:289699
		EGF_3	1542..1578	CDD:289699
		Fasciclin	1611..1711	CDD:280607
		Fasciclin	1734..1864	CDD:280607
		EGF_3	2085..2120	CDD:289699	8/34 (24%)
		EGF_3	2128..2163	CDD:289699	10/35 (29%)
		Link_domain_TSG_6_like	2198..2290	CDD:239592
		Fasciclin	2322..2448	CDD:295423
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1218
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900