DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment NimB1 and stab2

DIOPT Version :9

Sequence 1:	NP_001260452.1	Gene:	NimB1 / 34813	FlyBaseID:	FBgn0027929	Length:	403	Species:	Drosophila melanogaster
Sequence 2:	XP_017210540.1	Gene:	stab2 / 565194	ZFINID:	ZDB-GENE-041210-336	Length:	2543	Species:	Danio rerio

Alignment Length:	301	Identity:	86/301 - (28%)
Similarity:	113/301 - (37%)	Gaps:	103/301 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    91 CCAGYRRDPYANECVPDCSASSPDNC-RNGFC----RSPGVCECFAEFVRNEHGA---------- 140
            ||.||    :.|:|: :|..|:...| .||.|    ...|.|.|.:.|.    ||
Zfish    95 CCRGY----WGNDCM-ECPGSASTPCSNNGVCSDGIAGNGTCTCASGFT----GAACEECKTDLY 150

  Fly   141 ---CIHTCPIACQHGRCY--LNGT--CVCHQNFV-LD--QETRQFCRPKCSQ-SCGTHEECV--- 191
               |.:.|  .|::|.|.  |.||  |.|...:. ||  ||.     |.|:. .||....|:
Zfish   151 GPTCSNVC--RCKNGLCSSGLKGTGECTCFSGYTGLDCAQEL-----PACAALQCGPDSRCIEEM 208

  Fly   192 APGQ--CDCSPGYRRTPDLGCQPVCAPDCGFG-KCVAPNQCECFAGFIKRPNWNVCEAECYLNCE 253
            ..||  |.|.|||:               |.| :|.:.|.|      ::    :||.|
Zfish   209 LTGQLVCKCKPGYQ---------------GDGVQCTSINPC------LR----SVCHA------- 241

  Fly   254 NGLC----ESRYKCHCREGYRYDVNTTSCLP--ECS---DNCGQGNGVCI--APGV--CRCFRGY 305
            |.:|    .:::.|.|.|||..|...  |:|  .|.   .||..|:..|:  .||.  |.|..|:
Zfish   242 NAVCAHTGPNKHVCTCTEGYSGDGRV--CMPIDPCQTNLGNCTSGSTRCVYDGPGKAHCECLEGF 304

  Fly   306 E--VHGAECR--PKCESRFCGKYGRCVAPE----ICGCGEG 338
            |  |.|..|.  ..|:...|.||..|...|    .|.|.||
Zfish   305 EKFVEGQGCSIIDLCKPDSCHKYATCATAEPGTVECNCREG 345

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NimB1	NP_001260452.1	None
stab2	XP_017210540.1	EGF_3	239..268	CDD:289699	10/37 (27%)
		Fasciclin	374..495	CDD:280607
		Fasciclin	518..643	CDD:280607
		EGF_3	824..855	CDD:289699
		EGF_3	910..941	CDD:289699
		Fasciclin	1000..1119	CDD:280607
		Fasciclin	1135..1252	CDD:280607
		EGF_3	1465..1501	CDD:289699
		EGF_3	1550..1586	CDD:289699
		Fasciclin	1616..1716	CDD:280607
		Fasciclin	1742..1873	CDD:280607
		EGF_3	2076..2111	CDD:289699
		EGF_3	2117..2154	CDD:289699
		Link_Domain	2188..2280	CDD:295393
		FAS1	2345..2438	CDD:214719
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1218
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900