DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ance-3 and ace2

DIOPT Version :9

Sequence 1:	NP_001033904.1	Gene:	Ance-3 / 34808	FlyBaseID:	FBgn0032536	Length:	844	Species:	Drosophila melanogaster
Sequence 2:	XP_005169416.1	Gene:	ace2 / 492331	ZFINID:	ZDB-GENE-041114-6	Length:	818	Species:	Danio rerio

Alignment Length:	595	Identity:	218/595 - (36%)
Similarity:	327/595 - (54%)	Gaps:	19/595 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly   211 EKLRILLVESDQKGSLECTANVAAQWNFETNVNDFTQTEALNAQQRYVEFQRITAEQSKRINKDL 275
            ::.|..|.:.|::.|........|.|.:.|:::.....:...|...:.|:....:|:|.....|.
Zfish    22 DRAREFLNKFDEEASDIMYQYTLASWAYNTDISQENADKEAEAYAIWSEYYNKMSEESNAYPIDQ 86

  Fly   276 IFDRRLYRQLMLQSEVGPNALPLDVLDRYNRLLNEMLFLYNSAEICAYQQPFQCDLHYIPQLKDI 340
            |.|..:..||....:.|..||..|.......:::||..:||:|.:|....|..|.. ..|.|:.|
Zfish    87 ISDPIIKMQLQKLQDKGSGALSPDKASELRNIMSEMSTIYNTATVCKIDDPTDCQT-LEPGLESI 150

  Fly   341 MAKSRDWDELQHTWVEYHRKAGRGMRDSYEQLIDVMQEVAYVNNVTNGGEYWYLAYES-----GN 400
            ||:|||:||..|.|..:....|..||..||:.:|:..|.|.:||..:.|:||...||:     .:
Zfish   151 MAESRDYDERLHVWEGWRVATGMKMRPLYEKYVDLKNEAAKLNNYEDHGDYWRGDYETIDDPKYS 215

  Fly   401 FRQDMDI-----VWEQIRPLYEGLHAYVRRKLRDYYGPDRINRIAPIPSHILGNMYGQSWSNVLD 460
            :.:|..|     ::::|.|||:.||||||.||:|.| |..|...|.:|:|:||:|:|:.|:|:..
Zfish   216 YSRDQVIEDARRIYKEILPLYKELHAYVRAKLQDVY-PGHIGSDACLPAHLLGDMWGRFWTNLYP 279

  Fly   461 ILIPYPGRKLIDVTPRMVEQGYTPQLMFQLAEEFFTSINMSAVGPEFYRNSIFEQPLDRRVLCEP 525
            ::||||.|..|||:..|||||:....:|:.||:||.|:||.|:...|:.||:|.:|.:|.|:|.|
Zfish   280 LMIPYPDRPDIDVSSAMVEQGWDEIRLFKEAEKFFMSVNMPAMFDNFWNNSMFIKPEERDVVCHP 344

  Fly   526 SAWDFCNRHDFRVKICTDINQRSLISVHHEMAHIQYFLQYRHLPKIFRNGANPAFHQAVGDAIGL 590
            :|||..||.|||:|:||.:|....::|||||.|.||.:.||:.|.:.|:|||..||:|||:.:.|
Zfish   345 TAWDMGNRKDFRIKMCTKVNMDDFLTVHHEMGHNQYQMAYRNHPYLLRDGANEGFHEAVGEIMSL 409

  Fly   591 SVSTPRHLQTLGLLQRSLDES-SYDINYLFTMAIDKVAFLPFALSLDNWRYDVFSGNANKRTMNC 654
            |.:||.|||:||||.....:. ..|||:|...|:..|..|||...|:.||:.||.....|.....
Zfish   410 SAATPSHLQSLGLLPSDFKQDYETDINFLLKQALTIVGTLPFTYMLEEWRWQVFKAKIPKDEWMQ 474

  Fly   655 HYWNLREKYSGIKPPVLRSEKDFDPGAKYHIPANIPYIKYFFSTVLQFQIYRGLCRESGQYVPGD 719
            .:|.::.:..|:...|.|.|...||.|.:|:..:..:|:||..|:.|||....||:.:|.
Zfish   475 QWWQMKRELVGVAEAVPRDETYCDPPALFHVSGDYSFIRYFTRTIYQFQFQEALCKAAGH----- 534

  Fly   720 PRKPLHQCDIYRQPAAGNILKTLMSKGASQPWQEVLEETLREGRLDGTALREYFAPLEEWLRQEN 784
             ..||::|||.....||:.|:.::..|.|..|...|||.....::|...|..||:.|.|||::||
Zfish   535 -TGPLYKCDITNSTKAGDKLRHMLELGRSMSWTRALEEVAGTTKMDSQPLLHYFSTLMEWLKEEN 598

  Fly   785 LRTNEYVGWN 794
            .:.|...|||
Zfish   599 QKNNRVPGWN 608

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ance-3	NP_001033904.1	M2_ACE	216..784	CDD:188999	211/578 (37%)
ace2	XP_005169416.1	M2_ACE	27..598	CDD:188999	211/578 (37%)
ace2	XP_005169416.1	Collectrin	630..781	CDD:293564
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3690
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D266227at33208
OrthoFinder	1	1.000	-	-		FOG0000442
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101615
Panther	1	1.100	-	-	O	PTHR10514
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	9	8.780