DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ance-3 and Ace

DIOPT Version :9

Sequence 1:	NP_001033904.1	Gene:	Ance-3 / 34808	FlyBaseID:	FBgn0032536	Length:	844	Species:	Drosophila melanogaster
Sequence 2:	NP_036676.1	Gene:	Ace / 24310	RGDID:	2493	Length:	1313	Species:	Rattus norvegicus

Alignment Length:	573	Identity:	241/573 - (42%)
Similarity:	351/573 - (61%)	Gaps:	23/573 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly   231 NVAAQWNFETNV---NDFTQTEALNAQQRYVEFQRITAEQSKRINKDL---IFDRRLYRQLMLQS 289
            :.||.|..:||:   |...|.||....|   ||..:..:::|.:.:.:   ..|::|.|.:....
  Rat    70 STAASWAHDTNITEENARLQEEAALINQ---EFAEVWGKKAKELYESIWQNFTDQKLRRIIGSVQ 131

  Fly   290 EVGPNALPLDVLDRYNRLLNEMLFLYNSAEICAYQQPFQC---DLHYIPQLKDIMAKSRDWDELQ 351
            .:||..|||....:||.||:.|..:|::.::|...:...|   |    |:|.:|:|.||::.::.
  Rat   132 TLGPANLPLTQRLQYNSLLSNMSRIYSTGKVCFPNKTATCWSLD----PELTNILASSRNYAKVL 192

  Fly   352 HTWVEYHRKAGRGMRDSYEQLIDVMQEVAYVNNVTNGGEYWYLAYESGNFRQDMDIVWEQIRPLY 416
            ..|..:|...|..::..|:....:..|....:..::.|.||...|||.:|.:.::.::.|:.|||
  Rat   193 FAWEGWHDAVGIPLKPLYQDFTALSNEAYRQDGFSDTGAYWRSWYESPSFEESLEHLYHQVEPLY 257

  Fly   417 EGLHAYVRRKLRDYYGPDRINRIAPIPSHILGNMYGQSWSNVLDILIPYPGRKLIDVTPRMVEQG 481
            ..|||:|||.|...||...||...|||:|:||:|:.|||.|:.|:::|:|.:..:|||..||::|
  Rat   258 LNLHAFVRRALHRRYGDKYINLRGPIPAHLLGDMWAQSWENIYDMVVPFPDKPNLDVTSTMVQKG 322

  Fly   482 YTPQLMFQLAEEFFTSINMSAVGPEFYRNSIFEQPLD-RRVLCEPSAWDFCNRHDFRVKICTDIN 545
            :....||::|||||||:.:|.:.|||:..|:.|:|.| |.|:|..|||||.||.|||:|.||.:.
  Rat   323 WNATHMFRVAEEFFTSLGLSPMPPEFWAESMLEKPADGREVVCHASAWDFYNRKDFRIKQCTRVT 387

  Fly   546 QRSLISVHHEMAHIQYFLQYRHLPKIFRNGANPAFHQAVGDAIGLSVSTPRHLQTLGLLQRSLDE 610
            ...|.:|||||.|:||:|||:.|....|.||||.||:|:||.:.||||||.||..:|||.|..::
  Rat   388 MDQLSTVHHEMGHVQYYLQYKDLHVSLRRGANPGFHEAIGDVLALSVSTPAHLHKIGLLDRVAND 452

  Fly   611 SSYDINYLFTMAIDKVAFLPFALSLDNWRYDVFSGNANKRTMNCHYWNLREKYSGIKPPVLRSEK 675
            ...|||||..||::|:|||||...:|.||:.||||.......|..:|.||.||.||.|||.|:|.
  Rat   453 IESDINYLLKMALEKIAFLPFGYLVDQWRWGVFSGRTPPSRYNYDWWYLRTKYQGICPPVARNET 517

  Fly   676 DFDPGAKYHIPANIPYIKYFFSTVLQFQIYRGLCRESGQYVPGDPRKPLHQCDIYRQPAAGNILK 740
            .||.|||:|||:..|||:||.|.|||||.::.||:|:|.      :.||||||||:...||..|:
  Rat   518 HFDAGAKFHIPSVTPYIRYFVSFVLQFQFHQALCKEAGH------QGPLHQCDIYQSTKAGAKLQ 576

  Fly   741 TLMSKGASQPWQEVLEETLREGRLDGTALREYFAPLEEWLRQENLRTNEYVGW 793
            .::..|.|:||||||::.:....||.:||.|||.|:.:||:::|.|..|.:||
  Rat   577 QVLQAGCSRPWQEVLKDLVGSDALDASALMEYFQPVSQWLQEQNQRNGEVLGW 629

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ance-3	NP_001033904.1	M2_ACE	216..784	CDD:188999	236/562 (42%)
Ace	NP_036676.1	Peptidase M2 1	36..636		241/573 (42%)
		Peptidase_M2	46..629	CDD:279709	239/571 (42%)
		Peptidase M2 2	637..1238
		Peptidase_M2	650..1227	CDD:279709
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3690
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D266227at33208
OrthoFinder	1	1.000	-	-		FOG0000442
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101615
Panther	1	1.100	-	-	O	PTHR10514
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	8	7.780