Protein Alignment Ance-3 and ACE

DIOPT Version :10

• Sequence 1: NP_001033904.1
• Gene: Ance-3 / 34808
• FlyBaseID: FBgn0032536
• Length: 844
• Species: Drosophila melanogaster
• Sequence 2: NP_000780.1
• Gene: ACE / 1636
• HGNCID: 2707
• Length: 1306
• Species: Homo sapiens
• Alignment Length: 576
• Identity: 230/576 - (39%)
• Similarity: 347/576 - (60%)
• Gaps: 10/576 - (1%)

  Fly   219 ESDQKGSLECTANVAAQWNFETNVNDFTQTEALNAQQRYVEFQRITAEQSKRINKDLIFDRRLYR 283
            |.|:...:.......|.||:.||:...|....|....:..........|:::.:.:.:.:..:.|
Human   655 EYDRTSQVVWNEYAEANWNYNTNITTETSKILLQKNMQIANHTLKYGTQARKFDVNQLQNTTIKR 719

  Fly   284 QLMLQSEVGPNALPLDVLDRYNRLLNEMLFLYNSAEICAYQQPFQCDLHYIPQLKDIMAKSRDWD 348
            .:....::...|||...|:.||::|.:|...|:.|.:|   .|....|...|.|.::||.||.::
Human   720 IIKKVQDLERAALPAQELEEYNKILLDMETTYSVATVC---HPNGSCLQLEPDLTNVMATSRKYE 781

  Fly   349 ELQHTWVEYHRKAGRGMRDSYEQLIDVMQEVAYVNNVTNGGEYWYLAYESGNFRQDMDIVWEQIR 413
            :|...|..:..||||.:...|.:.::::.:.|.:|...:.|:.|...||:.:..||::.::::::
Human   782 DLLWAWEGWRDKAGRAILQFYPKYVELINQAARLNGYVDAGDSWRSMYETPSLEQDLERLFQELQ 846

  Fly   414 PLYEGLHAYVRRKLRDYYGPDRINRIAPIPSHILGNMYGQSWSNVLDILIPYPGRKLIDVTPRMV 478
            |||..|||||||.|..:||...||...|||:|:||||:.|:|||:.|:::|:|....:|.|..|:
Human   847 PLYLNLHAYVRRALHRHYGAQHINLEGPIPAHLLGNMWAQTWSNIYDLVVPFPSAPSMDTTEAML 911

  Fly   479 EQGYTPQLMFQLAEEFFTSINMSAVGPEFYRNSIFEQPLD-RRVLCEPSAWDFCNRHDFRVKICT 542
            :||:||:.||:.|::||||:.:..|.|||:..|:.|:|.| |.|:|..|||||.|..|||:|.||
Human   912 KQGWTPRRMFKEADDFFTSLGLLPVPPEFWNKSMLEKPTDGREVVCHASAWDFYNGKDFRIKQCT 976

  Fly   543 DINQRSLISVHHEMAHIQYFLQYRHLPKIFRNGANPAFHQAVGDAIGLSVSTPRHLQTLGLLQRS 607
            .:|...|:..||||.|||||:||:.||...|.||||.||:|:||.:.||||||:||.:|.||...
Human   977 TVNLEDLVVAHHEMGHIQYFMQYKDLPVALREGANPGFHEAIGDVLALSVSTPKHLHSLNLLSSE 1041

  Fly   608 LDESSYDINYLFTMAIDKVAFLPFALSLDNWRYDVFSGNANKRTMNCHYWNLREKYSGIKPPVLR 672
            .....:|||:|..||:||:||:||:..:|.||:.||.|:..|...|..:|:||.||.|:.|||.|
Human  1042 GGSDEHDINFLMKMALDKIAFIPFSYLVDQWRWRVFDGSITKENYNQEWWSLRLKYQGLCPPVPR 1106

  Fly   673 SEKDFDPGAKYHIPANIPYIKYFFSTVLQFQIYRGLCRESGQYVPGDPRKPLHQCDIYRQPAAGN 737
            ::.|||||||:|||:::|||:||.|.::|||.:..||:.:|.      ..|||:||||:...||.
Human  1107 TQGDFDPGAKFHIPSSVPYIRYFVSFIIQFQFHEALCQAAGH------TGPLHKCDIYQSKEAGQ 1165

  Fly   738 ILKTLMSKGASQPWQEVLEETLREGRLDGTALREYFAPLEEWLRQENLRTNEYVGW 793
            .|.|.|..|.|:||.|.::....:..:..:|:..||.||.:|||.||....|.:||
Human  1166 RLATAMKLGFSRPWPEAMQLITGQPNMSASAMLSYFKPLLDWLRTENELHGEKLGW 1221

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ance-3	NP_001033904.1	M2_ACE	216..784	CDD:341055	225/565 (40%)
ACE	NP_000780.1	Peptidase_M2	40..623	CDD:460196
		Peptidase_M2	643..1221	CDD:460196	228/574 (40%)
		Juxtamembrane stalk. /evidence=ECO:0000269|PubMed:11274151	1215..1256		3/7 (43%)