DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ance-3 and ACE

DIOPT Version :9

Sequence 1:	NP_001033904.1	Gene:	Ance-3 / 34808	FlyBaseID:	FBgn0032536	Length:	844	Species:	Drosophila melanogaster
Sequence 2:	NP_000780.1	Gene:	ACE / 1636	HGNCID:	2707	Length:	1306	Species:	Homo sapiens

Alignment Length:	576	Identity:	230/576 - (39%)
Similarity:	347/576 - (60%)	Gaps:	10/576 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly   219 ESDQKGSLECTANVAAQWNFETNVNDFTQTEALNAQQRYVEFQRITAEQSKRINKDLIFDRRLYR 283
            |.|:...:.......|.||:.||:...|....|....:..........|:::.:.:.:.:..:.|
Human   655 EYDRTSQVVWNEYAEANWNYNTNITTETSKILLQKNMQIANHTLKYGTQARKFDVNQLQNTTIKR 719

  Fly   284 QLMLQSEVGPNALPLDVLDRYNRLLNEMLFLYNSAEICAYQQPFQCDLHYIPQLKDIMAKSRDWD 348
            .:....::...|||...|:.||::|.:|...|:.|.:|   .|....|...|.|.::||.||.::
Human   720 IIKKVQDLERAALPAQELEEYNKILLDMETTYSVATVC---HPNGSCLQLEPDLTNVMATSRKYE 781

  Fly   349 ELQHTWVEYHRKAGRGMRDSYEQLIDVMQEVAYVNNVTNGGEYWYLAYESGNFRQDMDIVWEQIR 413
            :|...|..:..||||.:...|.:.::::.:.|.:|...:.|:.|...||:.:..||::.::::::
Human   782 DLLWAWEGWRDKAGRAILQFYPKYVELINQAARLNGYVDAGDSWRSMYETPSLEQDLERLFQELQ 846

  Fly   414 PLYEGLHAYVRRKLRDYYGPDRINRIAPIPSHILGNMYGQSWSNVLDILIPYPGRKLIDVTPRMV 478
            |||..|||||||.|..:||...||...|||:|:||||:.|:|||:.|:::|:|....:|.|..|:
Human   847 PLYLNLHAYVRRALHRHYGAQHINLEGPIPAHLLGNMWAQTWSNIYDLVVPFPSAPSMDTTEAML 911

  Fly   479 EQGYTPQLMFQLAEEFFTSINMSAVGPEFYRNSIFEQPLD-RRVLCEPSAWDFCNRHDFRVKICT 542
            :||:||:.||:.|::||||:.:..|.|||:..|:.|:|.| |.|:|..|||||.|..|||:|.||
Human   912 KQGWTPRRMFKEADDFFTSLGLLPVPPEFWNKSMLEKPTDGREVVCHASAWDFYNGKDFRIKQCT 976

  Fly   543 DINQRSLISVHHEMAHIQYFLQYRHLPKIFRNGANPAFHQAVGDAIGLSVSTPRHLQTLGLLQRS 607
            .:|...|:..||||.|||||:||:.||...|.||||.||:|:||.:.||||||:||.:|.||...
Human   977 TVNLEDLVVAHHEMGHIQYFMQYKDLPVALREGANPGFHEAIGDVLALSVSTPKHLHSLNLLSSE 1041

  Fly   608 LDESSYDINYLFTMAIDKVAFLPFALSLDNWRYDVFSGNANKRTMNCHYWNLREKYSGIKPPVLR 672
            .....:|||:|..||:||:||:||:..:|.||:.||.|:..|...|..:|:||.||.|:.|||.|
Human  1042 GGSDEHDINFLMKMALDKIAFIPFSYLVDQWRWRVFDGSITKENYNQEWWSLRLKYQGLCPPVPR 1106

  Fly   673 SEKDFDPGAKYHIPANIPYIKYFFSTVLQFQIYRGLCRESGQYVPGDPRKPLHQCDIYRQPAAGN 737
            ::.|||||||:|||:::|||:||.|.::|||.:..||:.:|.      ..|||:||||:...||.
Human  1107 TQGDFDPGAKFHIPSSVPYIRYFVSFIIQFQFHEALCQAAGH------TGPLHKCDIYQSKEAGQ 1165

  Fly   738 ILKTLMSKGASQPWQEVLEETLREGRLDGTALREYFAPLEEWLRQENLRTNEYVGW 793
            .|.|.|..|.|:||.|.::....:..:..:|:..||.||.:|||.||....|.:||
Human  1166 RLATAMKLGFSRPWPEAMQLITGQPNMSASAMLSYFKPLLDWLRTENELHGEKLGW 1221

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ance-3	NP_001033904.1	M2_ACE	216..784	CDD:188999	225/565 (40%)
ACE	NP_000780.1	Peptidase M2 1	30..630
		Peptidase_M2	40..623	CDD:279709
		Peptidase M2 2	631..1232		230/576 (40%)
		Peptidase_M2	643..1221	CDD:279709	228/574 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3690
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S5260
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D266227at33208
OrthoFinder	1	1.000	-	-		FOG0000442
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101615
Panther	1	1.100	-	-	O	PTHR10514
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	8	7.730