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Protein Alignment Ance-2 and ACE2

DIOPT Version :9

Sequence 1:	NP_788042.1	Gene:	Ance-2 / 34806	FlyBaseID:	FBgn0032535	Length:	611	Species:	Drosophila melanogaster
Sequence 2:	NP_001358344.1	Gene:	ACE2 / 59272	HGNCID:	13557	Length:	805	Species:	Homo sapiens

Alignment Length:	630	Identity:	154/630 - (24%)
Similarity:	275/630 - (43%)	Gaps:	48/630 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 WIFAVLLLVGLTQAGSQPDATLERFLNETNQQLAVIYDQAVLAQLLNELRGPNDLVALLEIEVTD 66
            |:  :|.||.:|.|.|..:...:.||::.|.:...::.|:.||..       |....:.|..|.:
Human     6 WL--LLSLVAVTAAQSTIEEQAKTFLDKFNHEAEDLFYQSSLASW-------NYNTNITEENVQN 61

  Fly    67 -----DKLVKYVRTLTTRKAKFKRLGLGDSRQRRLLDKIPQLGYEALSGRDLKLVYALASSMSDN 126
                 ||...:::..:|....:....:.:...:..|..:.|.|...||....|.:..:.::||..
Human    62 MNNAGDKWSAFLKEQSTLAQMYPLQEIQNLTVKLQLQALQQNGSSVLSEDKSKRLNTILNTMSTI 126

  Fly   127 YHNVKLCAYKQPGNCTLRLIPEVQSIVQGSRDLDEIEYYWFEWRSRTGLATRSQFVDFMDLYKKT 191
            |...|:|....|..|.| |.|.:..|:..|.|.:|..:.|..|||..|...|..:.:::.|..:.
Human   127 YSTGKVCNPDNPQECLL-LEPGLNEIMANSLDYNERLWAWESWRSEVGKQLRPLYEEYVVLKNEM 190

  Fly   192 AQLNGYPRAEDYWFRSLELKGQETMN-----LLDRIMH---GLRPLFLQFHAHVRGSLRKMHGEH 248
            |:.|.|....|||....|:.|.:..:     |::.:.|   .::||:...||:||..|...:..:
Human   191 ARANHYEDYGDYWRGDYEVNGVDGYDYSRGQLIEDVEHTFEEIKPLYEHLHAYVRAKLMNAYPSY 255

  Fly   249 LVPRNRPYPQHLAEVFIGNAFRRVEAEWY-VDLPSPEIGLANITQELHRRGLSTTQRVFWNVAEY 312
            :.|.. ..|.||    :|:.:.|.....| :.:|..:....::|..:..:... .||:|....::
Human   256 ISPIG-CLPAHL----LGDMWGRFWTNLYSLTVPFGQKPNIDVTDAMVDQAWD-AQRIFKEAEKF 314

  Fly   313 FRALGFPQLENSLWTYAQKVSSDDDDR--CWHKAWRYYALPRTNF--TYCPLNDEERFFNMFEAQ 373
            |.::|.|.:....|..:......:..:  |...||   .|.:.:|  ..|.....:.|.......
Human   315 FVSVGLPNMTQGFWENSMLTDPGNVQKAVCHPTAW---DLGKGDFRILMCTKVTMDDFLTAHHEM 376

  Fly   374 SDLQYYRAASIQPTLLQEEPFPNFSDAIGKCFSMAASSPRFLRKLGMLRDNKWKELPARLNRLYI 438
            ..:||..|.:.||.||:......|.:|:|:..|::|::|:.|:.:|:|..:..::....:|.|..
Human   377 GHIQYDMAYAAQPFLLRNGANEGFHEAVGEIMSLSAATPKHLKSIGLLSPDFQEDNETEINFLLK 441

  Fly   439 QGLRVVFLLPVFYVLDRYRVEVLAGHIKADD-NEAYWRLTELYTGAAAPTKRTNEQFDVPAKLL- 501
            |.|.:|..||..|:|:::|..|..|.|..|. .:.:|.:.....|...|... :|.:..||.|.
Human   442 QALTIVGTLPFTYMLEKWRWMVFKGEIPKDQWMKKWWEMKREIVGVVEPVPH-DETYCDPASLFH 505

  Fly   502 MEVDDQYASNFLSIVLQFQLLKHFCTITGQFEMGNPRKPLDMCDLSDQRGIGEILKRAMSLGSSV 566
            :..|..:...:...:.|||..:..|      :......||..||:|:....|:.|...:.||.|.
Human   506 VSNDYSFIRYYTRTLYQFQFQEALC------QAAKHEGPLHKCDISNSTEAGQKLFNMLRLGKSE 564

  Fly   567 HYREVLKVLLGEPEISIDGLLTYFQPLQDWLQHQNQENNLEVGWT 611
            .:...|:.::|...:::..||.||:||..||:.||:  |..|||:
Human   565 PWTLALENVVGAKNMNVRPLLNYFEPLFTWLKDQNK--NSFVGWS 607

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.